IHydroxypropyl methylcellulose (HPMC) i-non-ionic, i-cellulose e-soluble yamanzi exutywe i-ether.Imbonakalo imhlophe ukuya kumgubo omthubi kancinane okanye imathiriyeli yegranular, ayinancasa, ayinavumba, ayinatyhefu, izinzile ngokwekhemikhali, kwaye inyibilika emanzini ukwenza isisombululo esigudileyo, esiselubala kunye nesibonakalayo.Enye yezona zinto zibalulekileyo ze-hydroxypropyl methylcellulose ekusetyenzisweni kukuba inyusa i-viscosity yolwelo.Isiphumo sokuqina sixhomekeke kwiqondo lepolymerization (DP) yemveliso, ukuxinwa kwe-cellulose ether kwisisombululo esinamanzi, izinga lokucheba, kunye nobushushu besisombululo.Kunye nezinye izinto.
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Uhlobo lolwelo lwesisombululo se-aqueous HPMC
Ngokubanzi, uxinzelelo lolwelo lokucheba lunokubonakaliswa njengomsebenzi wesantya sokucheba kuphela ƒ(γ), okoko nje kungaxhomekekanga kwixesha.Ngokuxhomekeke kuhlobo ƒ(γ), ulwelo lunokwahlulwa lube ziindidi ezahlukeneyo, ezizezi: ulwelo oluseNewtonian, ulwelo oludityanisiweyo, ulwelo oluyipseudoplastic kunye nolwelo lweplastiki yaseBingham.
I-cellulose ethers yahlulwe yangamacandelo amabini: enye yi-non-ionic cellulose ether kwaye enye yi-ionic cellulose ether.Kwi-rheology yezi ntlobo zimbini ze-cellulose ethers.SC Naik et al.yenze uphononongo olubanzi nolucwangcisiweyo oluthelekisayo kwi-hydroxyethyl cellulose kunye nezisombululo ze-sodium carboxymethyl cellulose.Iziphumo zibonise ukuba zombini izisombululo ze-cellulose ether ze-non-ionic kunye nezisombululo ze-ionic cellulose ether zaziyi-pseudoplastic.Ukuqukuqela, oko kukuthi, imiqukuqelo engeyiyo eyeNewtonian, isondela kulwelo lweNewtonian kuphela kwindawo ephantsi kakhulu.I-pseudoplasticity yesisombululo se-hydroxypropyl methylcellulose idlala indima ebalulekileyo kwisicelo.Umzekelo, xa isetyenziswa kwiingubo zokwaleka, ngenxa yeempawu zokucheba ezibhityileyo zezisombululo ezinamanzi, i-viscosity yesisombululo iyancipha ngokunyuka kwesantya sokucheba, nto leyo enceda ukusasazwa okufanayo kwamasuntswana e-pigment, kwaye ikwanyusa ulwelo lokutyabeka. .Isiphumo sikhulu kakhulu;ngelixa uphumle, i-viscosity yesisombululo inkulu kakhulu, ekhusela ngokufanelekileyo ukufakwa kwee-pigment particles kwi-coating.
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Indlela yoVavanyo lwe-HPMC yeViscosity
Isalathisi esibalulekileyo sokulinganisa umphumo wokuqina kwe-hydroxypropyl methylcellulose yi-viscosity ebonakalayo yesisombululo samanzi.Iindlela zokulinganisa i-viscosity ebonakalayo idla ngokubandakanya indlela ye-capillary viscosity, indlela ye-rotational viscosity kunye nendlela ye-viscosity yebhola ewayo.
apho: yi-viscosity ebonakalayo, mPa s;I-K yi-viscometer engatshintshiyo;d ubuninzi besampulu yesisombululo kwi-20/20 ° C;t lixesha lokuba isisombululo sidlule kwindawo ephezulu ye-viscometer ukuya kumanqaku aphantsi, s;Ixesha apho ioli eqhelekileyo ihamba nge-viscometer ilinganiswa.
Nangona kunjalo, indlela yokulinganisa i-capillary viscometer inzima kakhulu.I-viscosities yee-ethers ezininzi ze-cellulose kunzima ukuyihlalutya ngokusebenzisa i-capillary viscometer kuba ezi zisombululo ziqulethe umkhondo wezinto ezinganyibilikiyo ezifunyenwe kuphela xa i-capillary viscometer ivaliwe.Ngoko ke, abaninzi abavelisi basebenzisa i-viscometers ejikelezayo ukulawula umgangatho we-hydroxypropyl methylcellulose.I-Brookfield viscometers isetyenziswa ngokuqhelekileyo kumazwe angaphandle, kwaye i-NDJ viscometers isetyenziswa eChina.
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Imiba enempembelelo ye-HPMC viscosity
3.1 Ubudlelwane kunye neqondo lokuhlanganisa
Xa ezinye iiparitha zihlala zingatshintshi, i-viscosity ye-hydroxypropyl methylcellulose isisombululo ihambelana neqondo le-polymerization (DP) okanye ubunzima bemolekyuli okanye ubude be-molecular chain, kwaye inyuka ngokunyuka kwezinga le-polymerization.Esi siphumo sibonakala ngakumbi kwimeko yeqondo eliphantsi le-polymerization kunokuba kwimeko yezinga eliphezulu le-polymerization.
3.2 Ubudlelwane phakathi kwe-viscosity kunye nokugxila
I-viscosity ye-hydroxypropyl methylcellulose iyanda ngokunyuka koxinzelelo lwemveliso kwisisombululo samanzi.Nokuba utshintsho oluncinci loxinzelelo luya kubangela utshintsho olukhulu kwi-viscosity.Nge-viscosity ebizwa ngokuba yi-hydroxypropyl methylcellulose Umphumo wenguqu yoxinzelelo lwesisombululo kwi-viscosity yesisombululo kubonakala ngakumbi.
3.3 Ubudlelwane phakathi kwe-viscosity kunye nereyithi yokucheba
I-Hydroxypropyl methylcellulose isisombululo samanzi sinepropathi yokucheba.I-Hydroxypropyl methylcellulose ye-viscosity eyahlukileyo ye-nominal ilungiswa kwi-2% yesisombululo samanzi, kunye ne-viscosity yayo kumazinga ahlukeneyo okucheba alinganiswa ngokulandelelana.Iziphumo zezi zilandelayo Njengoko kubonisiwe kumzobo.Kwinqanaba eliphantsi le-shear, i-viscosity ye-hydroxypropyl methylcellulose isisombululo ayizange itshintshe kakhulu.Ngokunyuka kwezinga lokucheba, i-viscosity ye-hydroxypropyl methylcellulose isisombululo esine-viscosity ephezulu ye-nominal yehle ngokucacileyo, ngelixa isisombululo esine-viscosity ephantsi asizange sehle ngokucacileyo.
3.4 Ubudlelwane phakathi kwe-viscosity kunye nobushushu
I-viscosity yesisombululo se-hydroxypropyl methylcellulose ichaphazeleka kakhulu ngubushushu.Njengoko iqondo lokushisa linyuka, i-viscosity yesisombululo iyancipha.Njengoko kuboniswe kumzobo, kulungiselelwe kwisisombululo samanzi kunye ne-concentration ye-2%, kwaye ukuguqulwa kwe-viscosity kunye nokunyuka kweqondo lokushisa kulinganiswa.
3.5 Ezinye izinto ezinefuthe
I-viscosity yesisombululo se-aqueous ye-hydroxypropyl methylcellulose iphinda ichaphazeleke izongezo kwisisombululo, ixabiso le-pH lesisombululo, kunye nokuthotywa kwe-microbial.Ngokuqhelekileyo, ukuze ufumane ukusebenza kakuhle kwe-viscosity okanye ukunciphisa iindleko zokusetyenziswa, kuyimfuneko yokongeza i-rheology modifiers, njengodongwe, udongwe olulungisiweyo, i-polymer powder, i-starch ether kunye ne-aliphatic copolymer, kwisisombululo samanzi se-hydroxypropyl methylcellulose., kunye ne-electrolytes ezifana ne-chloride, i-bromide, i-phosphate, i-nitrate, njl.Ezi zongezo aziyi kuchaphazela kuphela iimpawu ze-viscosity zesisombululo samanzi, kodwa zichaphazela nezinye iimpawu zesicelo se-hydroxypropyl methylcellulose ezifana nokugcinwa kwamanzi., ukuxhathisa kwe-sag, njl.
I-viscosity yesisombululo se-aqueous ye-hydroxypropyl methylcellulose phantse ayichatshazelwa yi-asidi kunye ne-alkali, kwaye ngokuqhelekileyo izinzile kuluhlu lwe-3 ukuya kwi-11. Inokumelana nomlinganiselo othile we-acids ebuthakathaka, njenge-formic acid, i-acetic acid, i-phosphoric acid. , i-boric acid, i-citric acid, njl. Nangona kunjalo, i-asidi egxininisiweyo iya kunciphisa i-viscosity.Kodwa i-caustic soda, i-potassium hydroxide, i-lime yamanzi, njl.Xa kuthelekiswa nezinye i-cellulose ethers, i-hydroxypropyl methylcellulose isisombululo se-aqueous sinokuzinza okulungileyo kwe-antimicrobial, isizathu esona sizathu kukuba i-hydroxypropyl methylcellulose inamaqela e-hydrophobic anezinga eliphezulu lokutshintshwa kunye nokuphazamiseka kwamaqela, nangona kunjalo, ekubeni i-substitution reaction idla ngokungafaniyo, iyunithi ye-anhydroglucose engatshintshiyo. eyona nto ikhukuliswa lula ziintsholongwane, okukhokelela ekuthotyweni kweemolekyuli ze-cellulose ether kunye nechain scission.Ukusebenza kukuba i-viscosity ebonakalayo yesisombululo samanzi iyancipha.Ukuba kuyimfuneko ukugcina isisombululo samanzi se-hydroxypropyl methylcellulose ixesha elide, kucetyiswa ukuba ungeze umlinganiselo we-antifungal agent ukwenzela ukuba i-viscosity ingatshintshi kakhulu.Xa ukhetha i-anti-fungal agents, i-preservatives okanye i-fungicides, kufuneka ubeke ingqalelo ekukhuseleni, kwaye ukhethe iimveliso ezingenayo ityhefu emzimbeni womntu, zinezakhiwo ezizinzileyo kwaye azinavumba, njenge-DOW Chem's AMICAL fungicides, i-CANGUARD64 preservatives, i-FUELSAVER bacteria agents. kunye nezinye iimveliso.inokudlala indima ehambelanayo.
Ixesha lokuposa: Oct-20-2022