I-hydroxypropyl methyl cellulose iyibona njani i-viscosity yayo ye-HPMC?

Masithethe nge-hydroxypropyl methyl cellulose HPMC kunye nendlela yokulinganisa i-viscosity yayo.I-viscosity apha ibhekiselele kwi-viscosity ebonakalayo, eyona nkcazo ebalulekileyo kwi-hydroxypropyl methyl cellulose.

Umgangatho.Iindlela eziqhelekileyo zokulinganisa ukulinganisa i-viscosity ejikelezayo, ukulinganisa i-capillary viscosity kunye ne-viscosity yokuwa.Indlela yokumisela i-hydroxypropyl methyl cellulose yayiyi-capillary adhesion.

Indlela yokuzimisela kwesidanga, usebenzisa i-Uchs viscometer.Ngokuqhelekileyo ukumiselwa kwesisombululo yi-2% yesisombululo samanzi, ifomula yile: V=Kdt.I-V yi-viscosity kwi-mpa.s kunye no-K yi-viscometer engatshintshiyo.

I-D yingxinano kwiqondo lokushisa elingaguqukiyo kwaye i-T lixesha ukusuka phezulu ukuya ezantsi ngokusebenzisa i-viscometer ngemizuzwana.Le ndlela yokusebenza inzima ngakumbi, ukuba kukho into enganyibilikiyo.

Amagama kulula ukubangela iimpazamo, kunzima ukuchonga umgangatho we-hydroxypropyl methyl cellulose.Ngoku isetyenziswa ngokuqhelekileyo ukulinganisa i-viscosity ye-viscometer ye-rotary, ukusetyenziswa ngokubanzi e-China.

Ifomula ye-viscometer ye-NDJ-1 ithi η=Kα.η yi-viscosity, kwakhona kwi-mpa.s, K ngumlinganiso we-viscometer, kwaye α kukufundwa kwesalathisi se-viscometer.

IHydroxypropyl methyl cellulose 2% indlela yokuvavanya i-viscosity:

I-1, le ndlela ifanelekile ukuzimisela kwe-viscosity eguquguqukayo ye-non-Newtonian fluids (isisombululo se-polymer, ukumiswa, i-emulsion dispersion liquid okanye isisombululo se-surfactant, njl.).

2. Izixhobo kunye nezixhobo

2.1 I-viscometer ye-Rotary (i-NdJ-1 kunye ne-NDJ-4 ifunwa yi-Chinese Pharmacopoeia)

2.2 Ubushushu bebhafu yamanzi rhoqo ukuchaneka kweqondo lobushushu 0.10C

2.3 Iqondo lobushushu lokufumana amanqaku yi-0.20C, eqinisekiswa ngamaxesha athile.

2.4 Imitha yee-frequency meters Ii-Viscometers ezisebenzisa iindlela zokuzinzisa amaza (ezifana ne-NDJ-1 kunye ne-NDJ-4) ziya kugcinwa.Ukuchaneka kwe-1%.A

8. Isampulu ye-Og yalinganiswa ngokuchanekileyo kwaye yafakwa kwibhekile eyomileyo, enethoni ye-400mL ubude.Yongeza malunga ne-100mL yamanzi ashushu angama-80-90 kwaye ugxobhoze i-10min ukuze uhlukane.

Ngokulinganayo ukusabalalisa, ugxobhoze kwaye wongeze amanzi abandayo kwi-400mL ngokupheleleyo.Okwangoku, xuba ngokuqhubekayo i-30min ukwenza isisombululo se-2% (W / W), kwaye usibeke efrijini ukuze uhlambe umkhenkce uphole de wenze umkhenkce obhityileyo phezu komhlaba.

Khupha kwaye ubeke kwitanki yobushushu engaguqukiyo ukugcina ubushushu obuphakathi ukuya kuma-20 ℃ 0.1 ℃.

3.1 Ufakelo kunye nokusebenza kwesixhobo kuya kwenziwa ngokuhambelana nemiyalelo yokusebenza kwesixhobo, kwaye i-rotor efanelekileyo kunye ne-rotor iya kukhethwa ngokuhambelana noluhlu lwe-viscosity yemveliso evavanyiweyo kunye nezibonelelo ze-pharmacopoeia phantsi kwesicatshulwa. imveliso

Isantya sokujikeleza.

3.2 Lungisa ubushushu obungaguqukiyo bamanzi ngokumiselwa phantsi kwento nganye yechiza.

3.3 Imveliso yovavanyo yafakwa kwisitya esichazwe sisixhobo, kwaye i-Angle yokuphambuka (a) yalinganiswa ngokomthetho emva kwemizuzu engama-30 yobushushu obuqhubekayo.Cima injini kwaye uyiqalise kwakhona ukuzimisela kwakhona

Umahluko phakathi kwamaxabiso aphakathi akumele udlule kwi-3%, ngaphandle koko kufuneka kwenziwe umlinganiselo wesithathu.

3.4 Bala ixabiso elilinganisiweyo leemvavanyo ezimbini ngokwefomula yokufumana i-viscosity eguquguqukayo yemveliso evavanyiweyo.

4. Bhala uze ubale

4.1 Rekhoda imodeli ye-viscometer ye-rotary, inombolo ye-rotor kunye nesantya esisetyenzisiweyo, i-viscometer constant (i-K 'value), iqondo lokushisa elilinganisiweyo, kunye nomlinganiselo ngamnye.Ixabiso.

Ifomula yokubala ka-4.2

Dynamic viscosity (MPa”s)=Ka apho i-K isisingqinisiso esihlala silinganiswa ngolwelo oluqhelekileyo lwe-viscosity eyaziwayo kunye no-A yi-Engile yokujika.