Kutheni i-HPMC isetyenziswa kwifilimu

Itekhnoloji yokuthobela ifilimu isetyenziswa ngokubanzi kumzi-mveliso wamayeza, ngakumbi ekuvelisweni kwamachiza omlomo. Ukudibana kwefilimu akunakuphela nje ukuphucula ukubonakala kweziyobisi, kodwa kukuphucula uzinzo lwamachiza, ukulawula inqanaba lokukhupha, ukugubungela ivumba elibi okanye ubukrakra beziyobisi, kunye nokuphucula ukuthotyelwa kwesigulana. Phakathi kwazo, i-Hydroxypropyl Methylcelcelculose (i-HPMC), njengezinto eziqhelekileyo zokuzihlola, sele yenye yezithako ezibalulekileyo kwi-filimu ngenxa yokusebenza kakhulu kunye nokuhambelana okuhle.

1. Iipropathi ezisisiseko ze-HPMC
I-HPMC yindawo ye-polymer efunyenwe ngokutshintsha kweekhemikhali zeselutase yendalo. Ifunyanwa ikakhulu yi-sellyulose emva kwe-hydroxylpropyl kunye nonyango lwe-methylity, kwaye lunomoya ofanelekileyo wokuzeliswa kwamanzi kunye ne-biomatise. Ukuluka kunye nokubonisa i-HPMC emanzini kunokulawulwa ngokuhlengahlengiswa kwesakhiwo sayo semolekyuli, ukuze sikwazi ukuziqhelanisa neemfuno zokwenziwa kwale. Ukongeza, i-HPMC inozinzo oluhle lobushushu, uzinzo lwekhemikhali kunye ne-biodegradiance, kwaye ayinatyhefu kwaye ayinabungozi, ihlangabezana neemfuno zokhuseleko zeziyobisi.

I-2. Izibonelelo ze-HPMC njengokukhathazeka kwefilimu
2.1 Ipropathi yokwakha ifilimu
I-HPMC inepropathi efanelekileyo yefilimu. Emva kokupheliswa, i-HPMC inokwakha ngokukhawuleza umboniso wefilimu kumphezulu wecwecwe, kunye namandla efilimu, ukugudla kunye nokungafihli nto konke konke konke kulungile. Oku kuyivumela ukuba kuqinisekiswe ukubonakala kwesiyobisi kwichiza xa isetyenziswa njengezixhobo zokuhamba, yandisa isibongozo sentengiso yechiza, kwaye saphucula ukusebenza kwechiza emzimbeni.

2.2 Isiphumo esilawulwayo
I-HPMC ineempawu zokulawula inqanaba lokukhutshwa ngamachiza, kwaye isetyenziswe ngokubanzi kumalungiselelo alawulwayo. Xa i-HPMC isetyenziswa njengenxalenye yefilimu yokuqesha ifilimu, inokulawula inqanaba lokukhutshwa kwechiza ngokusebenzisa ifilimu. Ngakumbi amalungiselelo aqinileyo aqinileyo, umaleko oqengqelekayo unokuchaphazela inkqubo yokupheliswa kwesiyobisi, emva koko ukufezekisa ukukhutshwa okuzinzileyo okanye umsebenzi wokukhululwa kweziyobisi kwi-gestrointenal phecanal phecanal. Umzekelo, i-HPMC inokukhupha ngokuthe ngcembe ichiza ngokufumana amanzi kunye nokudumba kwi-gestrointenal phecanal, inciphise umgangatho wokukhululwa kwechiza, kwaye iyakuphepha ukuqhutywa kwesiyobisi ngexesha elifutshane kunye nokunciphisa iziphumo ebezingalindelekanga.

2.3 Inzuzo yokuzinza kweziyobisi
I-HPMC COAT inokukhusela ngokufanelekileyo izithako zeziyobisi kwaye iwathintele ekuthandeni okanye ekuthandeni i-oxidation kwindawo yangaphandle, ngakumbi amachiza anomdla wokufuma, ukukhanya okanye umoya. Ifuthe lezithintelo ezenziweyo yifilimu ehlekisayo inokuthintela ngokufanelekileyo ichiza ekunxibelelaneni nemeko yangaphandle kwaye inciphise ukungakwazi kwechiza. Umzekelo, i-HPMC inokuthintela impembelelo yokufuma kunye nomoya kwichiza, ngaloo ndlela iphucule ukugcinwa kozilo lweziyobisi.

2.4 Ukuphucula imbonakalo kunye nokungcamla ichiza
I-HPMC inobala oluhle, olunokwenza umphezulu wechiza olugudileyo kwaye luyekele ubuhle bechiza, kunye nokuphucula ukwamkelwa kwesigulana. Ukongeza, i-HPMC inokugubungela ubukrakra okanye ivumba elibi lechiza kwaye liphucule incasa yechiza. Ngokukodwa amanye amachiza anencasa engalunganga, njengamalungiselelo amayeza okubulala iikhemizi okanye ukusetyenziswa kweekhemikhali, ukusetyenziswa kwe-HPMC kunokuphucula kakhulu amava amayeza eyeza isigulana, ngakumbi abaguli kunye nokuphucula ukuthotyelwa koguli.

I-2,5 ye-biomatisiatiso kunye nokhuseleko
I-HPMC isuselwa kwiseli yendalo, inee-biomitines elungileyo kunye ne-biodegradiance, kwaye ayibangeli ityhefu ebonakalayo emzimbeni womntu. Ke ngoko, i-HPMC ingasetyenziswa ngokukhuselekileyo ekuvelisweni kwamachiza omlomo njengento yokuthoba ifilimu ngaphandle kweziphumo ezingalunganga emzimbeni womntu. Inokucaphuka kancinci kwiphecana le-gastrointenal kwaye aliyi kubangela umthwalo obalulekileyo emzimbeni womntu emva kokusebenzisa.

2.6 Uluhlu olubanzi lwezicelo
I-HPMC njengento yokudlala ifilimu ilungele ukuveliswa kwamalungiselelo ahlukeneyo, ngakumbi amalungiselelo ahlukeneyo ezemidlalo, i-HPMC inokutshintsha ukusetyenziswa kwayo kunye neemeko zokuchitha ngokweemfuno ezithile. Oku kwenza ukuba i-hpmc iguqukele kakhulu kwaye iguquguquka, kwaye inokuhlangabezana neemfuno ezikhutshelweyo zamachiza ahlukeneyo. Nokuba ngamasuntswana aqinileyo, amacwecwe, okanye i-capsules, i-HPMC inokusetyenziselwa ukuqeqesha.

3. Imizekelo yesicelo yefilimu ye-HPMC
Kwizicelo ezisebenzayo, i-HPMC isetyenziswa ngokubanzi njengezinto zokugcina ifilimu kwiintlobo ngeentlobo zamayeza ezenza amayeza. Umzekelo, kumalungiselelo athile angenzi iziyobisi ezingeyonyani ze-sterodal (NSAIDS) njenge-Ibuprofen kunye ne-Acetaminophen, i-Acetaminophen, i-Acetaminophen, i-Acetaminophen, i-Acetaminophen, i-HPMC isetyenziselwa ukukhululeka kwi-Gestrointenal Tect. Ukongeza, ekukhuthazeni iziyobisi, i-HPMC ikwasetyenziswa ekuphuhlisweni kolawulo olulawulwayo okanye ukulibaziseka-ukukhutshwa kwe-HPMC kwi-HEPMC kwi-HEABMC kwi-Cemict kwiNkqubo yokuSebenza ngeziyobisi.

Njengesixhobo sokuhlola ifilimu, i-HPMC ineengenelo ezingenakufikelelwa kumalungiselelo amachiza. Ayiboneleli kuphela iipropathi eziguqula ifilimu kunye nozinzo, kodwa zilawula umyinge wokukhulula, iphucula incasa kunye nembonakalo yeziyobisi, kunye nokonyusa ukuthotyelwa kwesigulana. I-HPMMC's biomatisi -c's biomitiment ye-HPMC, engabotshwayo, kwaye i-quiptial elungileyo yenza inxalenye ebalulekileyo yetekhnoloji yefilimu yale filimu. Kwixesha lokuqulunqwa kweziyobisi kwi-HPMC, ngokungathandabuzekiyo bayaqhubeka nokudlala indima yayo ekhethekileyo kwaye bahlangabezane neemfuno zokwenziwa kweziyobisi ngakumbi.