Kutheni le nto i-selsulose i-Ether isetyenziswe ngokubanzi kubantu abathandanayo?

I-EMARMUCEIL CLOORDISI ZESIBONELELO NOKWENZIWA KOKUSETYENZISWA KOKUVUNYELWA KWEEMPAHLA NOKUGQIBELA, kwaye yinxalenye ebalulekileyo yamalungiselelo amachiza amayeza. Njengesibetho sendalo esivela kwi-polymer yendalo, i-Selese-Itelulose i-biodegrades, engenatyhefu, iphantsi, i-shoydroxyl iselling Ixabiso lesicelo kwi-colorsment yamayeza. Okwangoku, iimveliso zezona zishishini zeselula zaseSelsulose zaseKhaya ikakhulu zisetyenziswa ikakhulu kwimimandla ephakathi kunye nezantsi yeshishini, kwaye ixabiso elongeziweyo aliphezulu. Ishishini lifuna ukutshintsha kunye nokuphucula ukuphucula ukusetyenziswa kweemveliso eziphezulu.

Amandla entengiso anezizathu zamayeza zinkulu

Abanelisiki bemidlalo badlala indima ebalulekileyo kuphuhliso kunye nemveliso yokwenziwa. Umzekelo, kumalungiselelo okukhulula okuzinzileyo, izixhobo zepolymer ezinje nge-Selersese isetyenziswa njengamayeza e-Pelmaceutical kwi-Pelleists, iifilimu ezinzileyo zeMatrix, iZithuthi eziGqibeleleyo zeZiyoli, iZithuthi eziZinzileyo, kunye ne-PERS. Amalungiselelo kunye namalungiselelo olawulo olwenziweyo asetyenziswe ngokubanzi. Kule nkqubo, ii-polymers ezifana ne-Ether SelerUlose isetyenziswa njengabathwali iziyobisi ukulawula izinga lokukhulula umzimba, oko kukuthi, kuyafuneka ukukhupha kancinci emzimbeni kwinqanaba elithile lokufezekisa injongo yonyango oluthile ukufezekisa iinjongo zonyango oluthile.

Ngokweenkcukacha-manani ezivela kwiSebe loPhando lweZhiyan, kukho iindidi ezingama-300 zezizathu ezidweliswe kwilizwe lam, kodwa xa kuthelekiswa ne-United States (i-United States) kunye ne-European Union (i-3,000 yeentlobo ze-European), kwaye iindidi zincinci. Amandla okuphuhliswa kwentengiso inkulu. Kuyaqondakala ukuba oonobumba abaphantsi abalishumi abaphezulu kumachiza entengiso yelizwe li-gelatin ye-gelatin, i-Sulrose, i-HPP, i-HPP, i-HPMCYPOPLL, i-HPP ye-HECMECYL, HPC, iLactose.

Amayeza amathandathu abonwabileyo i-ether

I-Ether Selese yendalo ligama eliqhelekileyo lothotho lwezinto zeselselose eziveliswa yindlela ye-alkali selutase kunye nearhente yokuthambisa phantsi kweemeko ezithile. Yimveliso apho amaqela e-hydroxyl kwi-macromolecules ye-sell okanye etshintshwe ngokupheleleyo ngamaqela e-Ether. I-Seleulose Teltulose isetyenziswe ngokubanzi kwi-petroleum, izinto zokwakha, iingubo, ukutya, amayeza, kunye neekhemikhali zemihla ngemihla. Kwimimandla eyahlukeneyo, iimveliso zeBanga leZiseko eziPhakathi zisezisiseko nakweziphelo eziphezulu zemveliso, ngexabiso elongeziweyo. Ngenxa yeemfuno ezisemgangathweni ezingqongqo, ukuveliswa kwe-GARMUCECICAL-Ibanga leeSelethelise I-Ether inzima. Kungatsho ukuba umgangatho weemveliso zebanga lamachiza unokumela amandla obuchwephesha be-Ether Arhente yeTeluplose. I-Seley Sethel idla ngokusongezwa njenge-blocker, izixhobo zeMatrix kunye ne-thickener ukwenza iitafile ze-matrix ezilungisiweyo, izixhobo zokuthintela inyibilikisi, ukukhulula okuzinzileyo.

I-Sodium Carboxymethyl Selelose

I-carboxeymethyl sedium sodium (i-CMC-na) sisisele i-ether ye-ether kunye nemveliso enkulu kunye nokusetyenziswa kwekhaya kunye nasemaphesheya. Yi-ionic setesulose ekutyuntshele kwikotoni kunye neenkuni nge-alkalization kunye ne-etheriya kunye ne-chlorocetic acid. I-CMC-na yindlela eqhelekileyo esetyenziswayo intsha. Ihlala isetyenziswa njengomgcini wamalungiselelo aqinileyo, ukwanda okungasandayo, ukuthambisa kunye nokumisa iarhente yamalungisa amanzi, kwaye kunokusetyenziswa njengempahla enyibilikayo ye-matrix kunye nefilimu. Ihlala isetyenziswa njengokukhutshwa kwefilimu yefilimu yefilimu kunye nethebhulethi ye-matrix ekhutshelweyo (elawulwa) yokukhululeka.

Ukongeza kwi-Sodium Carboxymethylcelcelcelcelcelcelose njengowona ungoyena nolangazelelo lwamayeza, i-cromarmellose sodium nayo isetyenziswa njengokungafuneki kwamayeza. I-Conscarmellose Slodium (CCMC-NA) Imveliso yebhokisi ye-carboxymethylcelose i-arhente yeqondo lokudibana kwisenzo esithile (i-40-80 ° C) phantsi kwesenzo se-inorgadic statalyst kwaye ihlanjululwe. Njengommeli onqamlezileyo, i-propylene glycol, i-proccinic anhydride, i-andhydride ye-anhydride kwaye ene-adhydride inokusetyenziswa. I-Croscarmellose Sodium isetyenziswa njenge-suinterble kwiitafile, iicaphule kunye neegranatis kumalungiselelo omlomo. Ixhomekeke kwi-capillary kunye nefuthe lokudumba ukuze linikezele. Inobulungisa obuhle kunye namandla omelele. Izifundo zibonakalise ukuba isidanga esivuyiweyo se-croscarmellose Slodium emanzini sikhulu kuneso sadium esezantsi ye-carmellose enamanzi kunye ne-rocrystalline ye-ricmellose.

Methylceluplose

I-Methyl Selelose (MC) yi-Ionic ye-ionic setesulose eyenzelwe i-ether engatshatanga eyenziwe kwikotoni kunye neenkuni nge-alkalition kunye ne-methyl chloride. I-methylcelfulose inolwazi olugqwesileyo lwamanzi kwaye luzinzile kuluhlu lwe-PH2.0 ~ 13.0. Isetyenziswe ngokubanzi kwi-subridels, kwaye isetyenziswa kwiitafile ze-sublical, inaliti ye-intsuramcular, i-Ophthalmic, iicaphus zomlomo, iitafile zomlomo kunye namalungiselelo aphezulu. Ukongeza, kumalungiselelo okukhutshwa kwe-MC, i-MC inokusetyenziswa njenge-hydrophilic gertix ye-gerix ye-tetrix, izixhobo zokuthintela i-gestric-inyibilikisi, ukukhulula okuzinzileyo kwe-microcapsule, ukukhutshwa kwefilimu, njl.

Hydroxypropylmethylcelcelcelcelcelose

I-HydroxyPOpyl Methylcelcelsele (i-HPMC) yi-ionic selsulose exubeneyo eyenziwe kwikotoni kunye neenkuni nge-alkalization, i-propylene oxide kunye ne-methyl chloride of thether. Yinto engenatyhafileyo, engenaxabiso, engenatyhefu, inyibilikisi emanzini ebandayo kwaye igqunywe ngamanzi ashushu. I-HydroxyPOpyl Methylcelcelcelose yi-selsulose yi-Ether exubene ne-Ether eyahlukeneyo, idosi kunye nomgangatho sele ikhule ngokukhawuleza e-China kule minyaka ili-15 idlulileyo. Yenye yezona zinto zisetyenziswa kakhulu zisetyenziswa kakhulu ekhaya nasephesheya. Iminyaka yembali. Okwangoku, ukusetyenziswa kwe-HPMC kuboniswa ikakhulu kwezi zinto zintlanu zilandelayo:

Enye injenge-binder kwaye intsholongwane. Njengomthi we-binder, i-HPMC inokwenza ichiza kulula emanzini, kwaye inokwandisa amakhulu amaxesha emva kokufumana amanzi, ukuze ikwazi ukuphucula umgangatho wokuchitha okanye inqanaba lokukhupha ithebhulethi. I-HPMC ine-viscofity eyomeleleyo, enokuphucula i-vercoficle i-viscosity kwaye iphucule ukutshintsha kwezinto ezingafunekiyo nge-crisp okanye i-bristtle. I-HPMC ene-viscofity ephantsi inokusetyenziswa njenge-binder kwaye ihlaze, kwaye abo banovimba abaphezulu banokusetyenziswa kuphela njenge-binder.

Okwesibini lunjengoko khululo oluzinzileyo nolulawulwayo lwamalungiselelo omlomo. I-HPMC yi-Hydrogel Matrix yeMatrix yeZilungiselelo eziZinzileyo. Ibakala lokufunda eliphantsi (i-5-50mpal lingasetyenziswa njenge-binder, i-viscosifier kunye nenqanaba lokumisa i-HPMCHAS) I-HPMC isetyenziselwa iitafile ze-cepsules, i-hydrophilic ges gestept ye-curix. I-HPMC inyibilikisi kwi-Gastrointentinal fluid, inezibonelelo zokungcola ezilungileyo, ulwelo oluhle, umthamo onamandla otyibilikayo, kunye neempawu zokukhupha iimpawu ezingachaphazelekanga yi-PH. Yinto ebaluleke kakhulu yokuthwala i-hydrophilic ye-hydrophilic ye-hydfilic yenkqubo yokulungiselela i-hydrophilic i-hydrophilic ger matrix kunye nezinto zokuzihlaziya iiNkqubo zokuKhulula eziZinzileyo, kunye nezixhobo ezincedisayo zokuSebenzisa iiMpuzi zeZiyonda.

Elesithathu linjengearhente yefilimu yokwakha ifilimu. I-HPMC ineepropathi ezifanelekileyo zefilimu. Ifilimu eyenziwe yiyunifomu, ebonakalayo kwaye inzima, kwaye akukho lula ukunamathela ngexesha lemveliso. Ngokukodwa amachiza alula ukuyifumana umswakama kwaye angazinzanga, ayisebenzisa njengokuphucula ungqingqwa. I-HPMC ineendlela ezahlukeneyo zokufakelwa. Ukuba ikhethiwe ngokufanelekileyo, umgangatho kunye nokubonakala kweetafile ezinamaphepha adityanisiweyo ziphezulu kwezinye izinto. Uxinzelelo oluqhelekileyo olusetyenzisiweyo yi-2% ukuya kwi-10%.

Elesine linjengesithuba secaphu. Kwiminyaka yakutshanje, ngokuqhambuka okuqhelekileyo kwehlabathi, xa kuthelekiswa ne-gelatin capsules, iicaphu zemifuno ziba sisithandwa esitsha samayeza kunye nokutya. I-Pfizer ye-United States ikhuphe ngempumelelo i-HPMC evela kwizityalo zendalo kunye ne-vcaps elungisiweyo ye-vcaptm. Xa kuthelekiswa ne-gelatini yemveli ye-gelatini, iicapsules ezityalonile zinezinto eziluncedo kuzinzo olubanzi, akukho mngcipheko wokuphendula ngokudibeneyo kunye nokuzinza okuphezulu. Ireyithi yokukhupha iziyobisi ihleli, kwaye umahluko umntu mncinci. Emva kokuhluma komzimba womntu, ayikhutshwa kwaye inokukhupha into iyenziwa emzimbeni. NgokweMeko yokuGcina, emva kwenani leemvavanyo ezinkulu, phantse azikho brittle phantsi kweemeko zokufuma okuphantsi, kwaye iipropathi zeqokobhe le-capsule zisazinza phantsi kweemeko eziphakamileyo, kwaye izikhombisi zeecopsules azichaphazelekanga. Ukuqonda kwabantu iicapbules zezityalo kunye notshintsho lwamayeza oluntu ekhaya nasephesheya, imfuno yentengiso ye-capsules yokutyala iya kukhula ngokukhawuleza.

Isihlanu sinjengearhente yokumisa. Ukulungiswa kokunqunyanyiswa kwenkqubo yekliniki esetyenziswayo yeKlinikhi yeKlinikhi, eyinkqubo yokusasazeka kwe-heterogeneneous apho iziyobisi eziqinileyo zingachithwanga kwindawo yokusasazeka kwerestu. Uzinzo lwenkqubo lubonisa umgangatho wokulungiswa kwamanzi okumiswa. Isisombululo se-HPMC Colloidal sinokunciphisa uxinzelelo oluqinileyo olunamandla, ukunciphisa amandla asimahla samasuntswana amasuntswana, kwaye uzinzile inkqubo ye-heterogeneous yokusasazeka. Yiarhente enokumisa kakhulu. I-HPMC isetyenziswa njenge-thickener yehla, ngomxholo we-0.45% ukuya kwi-1,0%.

Hydroxypropyl seluplose

I-Hydroxypropyl seluplose (HPC) yi-ionic selsulose ye-unic ye-ionsulose eyenziwe kwikotoni kunye neenkuni nge-alkalization kunye ne-propylene oxide. I-HPC ihlala inyibilikisi emanzini ngezantsi kwe-40 ° C kunye nenani elikhulu leendlela ze-polar, kwaye intsebenzo yayo ihambelana nomxholo weqela le-hydroxpropy kunye nenqanaba le-polymerization. I-HPC inokuhambelana namachiza ahlukeneyo kwaye ine-interia elungileyo.

I-hydroxypropyl ye-hydroprespy ye-hydulose (l-hpc) isetyenziswa ikakhulu njengecwecwe kunye ne-binder. -HPC inokuphucula ubunzima kunye nokuqaqamba kwethebhulethi, kwaye kunokwenza ukuba ithebhulethi isebenze ngokukhawuleza, ukuphucula umgangatho wangaphakathi wecwecwe, kunye nokuphucula isiphumo soqobo.

I-hydroxypropyl ye-hydroplopyl ye-hydroplopy ye-hydulose (H-HPC) inokusetyenziswa njenge-binder yeetafile, iigram, kunye negranti ehle kwintsimi yamayeza. I-H-HPC ineepropathi ezigqwesileyo zefilimu, kwaye ifilimu efunyenweyo inzima kwaye ine-elastiki, enokuthelekiswa neplastiki. Intsebenzo yefilimu inokuphuculwa ngakumbi ngokuxubana nezinye iiarhente zokunyanyelana nokunganyangekiyo, kwaye zihlala zisetyenziswa njengezinto zokuhamba ngefilimu zeetafile. I-H-HPC inokusetyenziswa njengezixhobo ze-matrix ukulungiselela iitafile ze-matrix ezigcinakileyo, iipelethi ezikhutshelweyo ezikhutshelweyo kunye neetafile ze-windows ezimbini.

Hydroxyyl seluplose

I-HydroxyEtheetheetheetheethl seluplose (hec) i-ionic ye-ionic setesulose eyenzelwe i-therton kunye neenkuni nge-alkali i-alkalition kunye ne-etheriya ye-ethlone oxide. Kwintsimi yamayeza, ihek isetyenziswa ikakhulu njenge-gickener, iarhente yokhuselo, imbeke, i-arhente yefilimu, itafile eqinileyo, itafile eqinileyo, ezinye iifom ze-dosage. I-HydroxyEteetheetheetheethy irekhodwe kwi-pharmacopoeia / i-US yase-US kunye ne-Euromaun Apharacoepoeia, njl.

I-Ethyl Selelose

I-Ethyl Selelose (EC) yenye yezona zinto zisetyenziswa kakhulu zesekela. I-EC ayinatyhefu, izinzile, ingenamanzi, isisombululo okanye isisombululo se-Alkali, kwaye inyibilikisi kwiinyibiliki ezifana ne-ethanol kunye ne-methanol. I-Solvent esetyenzisiweyo yi-scolvent yi-toluene / etshanol njenge-4 / (ubunzima) yenyibilikisiwe. I-EC isebenzisa izicelo ezininzi kwilungiselelo lokukhululwa kweziyobisi, isetyenziswa ngokubanzi njengeenqwelo zokusetyenziswa kweefilimu ezigcinakeleyo, ezisetyenziswa njengezixhobo ezizimeleyo ze-matrix, ezisetyenziswa njengezixhobo ezithengiweyo zefilimu, ezisetyenziswayo njengee-engection Izinto ezincedisayo ukulungiselela i-microcaps eneendleko ezikhululekileyo; Ingasetyenziswa ngokubanzi njengomxholo ophetheyo wokulungiselela ukusasazeka okuqinileyo; Isetyenziswe ngokubanzi kwitekhnoloji yamayeza njengento yokwenza ifilimu kunye nokukhubazeka kwefilimu kunye nokukhubazeka okukhuselayo, kunye ne-binder kunye nefilitha. Njengokukhusela ithebhulethi, inokunciphisa ubuntununtunu bethebhulethi kumngcipheko wokufuma kwaye kuthintele ichiza ukuba lichaphazeleke kukufuma, ukungqinelana kunye nokuwohloka nokuwohloka; Ikwanokwenza i-gel ye-gel yokukhuphela kancinci, i-microncapupling i-polymer, kwaye yenza ukuba ukukhutshwa okuzinzileyo kwesiphumo seziyobisi.

Susa izicelo zokuphela kokuphela kwaye ukukhawulezisa ukutshintsha kunye nokuphuculwa

Ngesishwankathelo, i-sodium ye-sodium ye-sodium ye-sodium ye-sodiumthymethyl seluplose, methyl seluplopyl methyulose, i-hydroxyEzyl seluplose isetyenziswe kwii-binders, i-suintergran, igcinwe kwaye Izixhobo zokukhutshwa ezilawulwayo zokulungiselela ngomlomo, ii-arhente zokwenza iifilimu zokuseka iifilimu, izixhobo zecaphule kunye neearhente zokumisa. Ukujonga umhlaba, iinkampani ezininzi zangaphandle ze-perizenal, i-Wow Wolfe kunye ne-Ashland Cross Dragon) sele ifumene intengiso enkulu yeselula ye-china kwixa elizayo, nokuba ikhulisa imizamo yabo kule ntsimi. igalelo lesicelo ngaphakathi. I-Dow Wolfe ixele ukuba iya komeleza ingqalelo yayo ekusetyenzisweni, izithako kunye nemfuno yemarike yamayeza amachiza aseTshayina, kwaye uphando lwayo olusetyenzisiweyo luya kuzama ukusondela kwintengiso. I-Dow Wolf Shocf Sulbase ye-Collegion kunye noMbala weComercon we-United States senze umanyano lwe-United States kwi-jikelele, kumaziko ama-15 ee-ATS, kunye neengcali ezi-6 zokusebenza ezisetyenziswayo zisebenza kubathengi kumazwe ali-160. I-Ashland ineziseko zemveliso eBeijing, eTianjin, Shanghai, i-nanjhai, i-changzhan kunye ne-Kunthan naseJiangmen, kwaye ityale imali kumaziko amathathu ophando eShanghai naseMjezingmes.

Ngokweenkcukacha-manani kwiwebhusayithi ye-China Selesese, ngo-2017, imveliso yasekhaya ye-Tobile yayiyiitoni ezingama-373,000, kwaye ivolumu yokuthengisa yayingama-360,000 iitoni. Ngo-2017, ivolumu yokuthengisa ye-Ionic ye-ionic yayingama-234,000 iitoni, ukunyuka kwe-18.61%, kunye nevolumu yentengiso ye-Ionic yayiyi-126% yonyaka-mali. Ukongeza kwi-HPMC (iBanga leZixhobo zeZixhobo), iimveliso ze-Ionic, i-HPMC (iBakala lasekhaya), i-HPMC (i-HPMC (i-HPMC (i-HPMC (i-HPMC), i-HPMC (i-HEC, i-HME, i-HMC. I-ether yasekhaya ikhule ngokukhawuleza ngaphezulu kweminyaka elishumi, kwaye iziphumo zayo ziye zaba ngowokuqala emhlabeni. Nangona kunjalo, iimveliso zenkampani enkulu kakhulu ye-ElesUlose isetyenziswa ikakhulu kwimimandla ephakathi kunye nezantsi yeshishini, kwaye ixabiso elongeziweyo aliphezulu.

Okwangoku, uninzi lwamashishini e-Ether ye-Eler Sether bakwixesha elinzima lenguqu kunye nokuphuculwa. Kuya kufuneka baqhubeke nokonyusa uphando lweMveliso kunye neenzame zophuhliso, ngokuqhubekayo zisebenzisa i-china, imarike enkulu, kwaye ingenise i-shishini ephakathi kunye nokuphuculwa komzi-mveliso, kwaye ifezekise uphuhliso nolweluhlaza.