Kutheni i-Selesese isete isetyenziswe ngokubanzi kubantu abathandana ngayo?

I-EMARMUCEIL CLOURISI ZESIBONELELO NEZIHLOKO ezisetyenziselwa ukuveliswa kunye nokusasazwa kwamachiza, kwaye yinxalenye ebalulekileyo yamalungiselelo ngamayeza. I-Seley Sether njengoko ithathiwe kwi-Polymer yeNdalo, ineempawu ze-biodegrades, ingenatyhefu, ityhefu, i-Hydroxylyl Itylulose, Estyl Selelose, SellydyEsethl Ixabiso elibalulekileyo lesicelo kwi-conmaricals. Okwangoku, uninzi lweemveliso zeshishini leselula lasekhohlo lisetyenziswa ikakhulu kwisiphelo seshishini, ixabiso elongeziweyo aliphakami, ishishini lifuna inguqu engxamisekileyo kunye nokuphuculwa, ukuphucula ukusetyenziswa kweemveliso eziphezulu.

Amachiza amachiza anokubakho kwintengiso inkulu

Abanelisiki bemidlalo badlala indima ebalulekileyo kuphuhliso kunye nemveliso yokulungiselela amayeza. Umzekelo, kumalungiselelo okukhulula, ukukhulula i-ether kunye nezinye izinto zePolymer njengezigculelo zamayeza, ukukhululwa kwenkqubo yokukhululwa, ukukhululwa kwemveliso eneemveliso, ukukhululwa kwefilimu, ukukhululwa kwe-resin. Kule nkqubo, i-Selessese Ether kwaye ezinye iipolimers zihlala zisetyenziswa njengesixhobo sokulawula iziyobisi somzimba, oko kukuthi, kufuneka zikhululwe kancinci emzimbeni kwixesha elithile lokufezekisa iinjongo zonyango oluthile.

Ngokweenkcukacha-manani ze-Zhiyan Distang kunye neSebe loPhando, i-China idweliswe malunga neentlobo zezixhobo, kodwa xa kuthelekiswa ne-United States (i-European United States, i-European United States yoPhuculo lweMali inkulu. Kuyaqondakala ukuba izivumelwano ezilishumi eziphezulu ze-chinarhed ze-China i-gelatin ye-gelatining, i-Sulrose, i-propylone Glycosel Metsulose (HPMC, i-HPMCSTALL, HPC, CLCE.

Ntandathuiintlobo zeI-Selersese EtherngaphakathiI-pharmaceutical

I-Ethe ye-SellUlose ye-Ether i-Alkali SellUlose kunye neArhente yeArhente phantsi kweemeko ezithile zokusabela ukuvelisa iQela le-Sellroxyl Hydroxyl Elly okanye itshintshwe ngokupheleleyo yimveliso. I-Telupelose Ether isetyenziswe ngokubanzi kwi-petroleum, izinto zokwakha, ukutya, ukutya, iikhemikhali zemihla ngemihla, kwiindidi zemihla ngemihla kwicandelo eliphezulu leli shishini, ngexabiso elongeziweyo. Ngenxa yeemfuno ezisemgangathweni ezingqongqo, ukuveliswa kweBanga leSelmmase Ether kuya kuba nzima ngakumbi, kunokutshiwo ukuba umgangatho weemveliso zebakala zamayeza unokumela amandla obuchwephesha be-Ether ye-Selese. I-Telupelose Ether ihlala isetyenziswa njenge-blocker, i-skeleton kunye ne-viscosifier i-skelept ye-skeleton, isisu-moya esinyibilikisiweyo, sikhutshiwe i-screen-khutshelo-sikhulule i-screen filtings.

I-Sodium Carboxymethyl Selelose

I-Sodium Carboxymethyl Selelose (CMC-NA) yesona sivuno sikhulu kunye ne-dosage ye-Ether ye-Ether ye-Seles ekhaya nakwamanyezwe, yenziwa nge-thekali, iinkuni ngu-Alkali, we-chlorocetic acid olwenziwe nge-ionic setesulose. I-CMC-NA iluhlobo lwezinto eziqhelekileyo ezisetyenziselwa amayeza, eziqhele ukusetyenziswa njengamalungiselelo aqinileyo amalungiselelo aqinileyo kunye ne-vickous, i-vickeus kunye nokumiswa kwezixhobo ze-matrix kunye ne-matrix yefix yefilimu. Kwindlela yokukhululeka (elawulwa) ukukhululwa, ihlala isetyenziswa njengempahla yefilimu yeziyobisi ngokukhululekileyo kunye neetafile zesakhelo sokukhululwa kancinci.

Ukongeza kwi-Sodium Carboxymethyl Selelose ye-conluceutical ye-chineces, i-Sodium yeSodium Carboxymethyl Secobose ikwanokusetyenziswa njengamachiza amayeza. I-Sodium enqamlezileyo ye-sodium ye-coboboxymethyl seluplose (ccmc-na) yindawo ecocekileyo ye-carboxymethyl ye-cartulose enqamlezileyo kwi-cortulose enqamlezileyo kwisenzo se-Inorganic Acid. I-arhente enqamlezileyo inokuba yi-Glyccone Glycol, iSucccinic Anhydride, i-andhydride ye-adhydride kunye ne-adhydride. I-Sodium enqamlezileyo ye-Sodium Carboxymethyl Secolose isetyenziswa njenge-arhente yokuhluza amacwecwe, i-capsules kunye ne-capillary kunye ne-capillary kunye nokudumba, amandla ayo, athatyathekayo, amandla ayo anento enqabileyo. Izifundo zibonakalise ukuba inqanaba lokudumba le-sodium le-sodium ye-sodium ye-coboxymethyl selsulose emanzini i-sodboxymethyl seluplose ye-sodium kunye ne-rocrystalline kunye neearhente eziqhelekileyo ze-rocracrystase kunye nezinye iiarhente eziqhelekileyo.

I-Methyl Selelose

I-Methyl Selelose (MC) sisimo esinye seSelulose Ether seether eyenziwe kwikotoni kunye neenkuni nge-alkalization, i-chloromethane ye-celomethane kunye nezinye iinkqubo. I-Methyl Selelose inomoya obalaseleyo wokuluka kwamanzi kwaye uzinzile kwi-PH Uluhlu lwe-2.0 ~ 13.0. Isetyenziswe ngokubanzi kwi-chiermaceuticals, iitafile ze-subranusculations, inaliti ye-intramuscular, i-Ophthalmic, iicaphus zomlomo, iitafile zomlomo kunye namalungiselelo endawo. Ukongeza, i-MC inokusetyenziswa njengenkqubo ye-hydrophilic ye-hydrophilic ye-gel, i-gestric inyibilikisi ye-gestric of inyibilikisi, ukukhulula okuzinzileyo

Hydroxypropyl methyl seluplose

I-HydroxyPOpyl Methyl Selelose (HPMC) yi-Infoulose ye-Ether exubeneyo eyenziwe kwikotoni kunye neenkuni nge-alkalization, i-propylene oxide kunye ne-celomethane ye-proromethane kunye ne-celomethane ye-proromethane kunye ne-celomethane ye-prodomethane kunye ne-celomethane ye-celomethane kunye ne-celomethane ye-prodomethane kunye ne-celomethane ye-proromethane. Yinto engenatyhefu, engenaxabiso kwaye engabinayo ityhefu, inyibilikiswe emanzini abandayo kunye ne-gelatinous emanzini ashushu. I-HydroxyPOpyl Methyl Selelose sisivuno sasekhaya, i-dosage kunye nomgangatho we-selsulose yoxube kule minyaka ili-15 idlulileyo iphucule ngokukhawuleza, ikwangugqirha olona nyango luphakathi kwimbali. Okwangoku, isicelo se-HPMC siboniswa ikakhulu kwezi zinto zintlanu zilandelayo:

Enye injenge-binder kunye nearhente yokuthintela. I-HPMC njenge-Binder inokwenza ichiza kulula emanzini, kwaye amanzi ayo anokwandisa amakhulu amaxesha, ukuze ikwazi ukuphucula ukuchitheka okanye ukukhutshwa kweetafile. I-HPMC ine-viscofity eyomeleleyo, yokutshekisha kwentlekele okanye izixhobo ze-Brittles ezinqabileyo zinokuphucula i-vercosity, ziphucule ukutyibilika kwayo. I-HPMC ye-HPMC Inokusetyenziswa njenge-binder kunye nearhente yokuthintela, i-viscofity ephezulu kuphela njenge-binder.

Okwesibini lunjengezinto zokukhupha kancinci kunye nokulawulwa kwamalungiselelo omlomo. I-HPMC yindawo yenkqubo ye-hydrogel ye-hydrogel isetyenziswa rhoqo kumalungiselelo okukhululeka. I-HPMC enenqanaba le-viscofity (5 ~ 50Mparo) inokusetyenziswa njengokufumana iarhente yokunamathela, i-HPMP enomgangatho ophezulu (i-4000 ~ i-100000 ye-Capparo) kunye neetafile ze-Hydrophilic ze-hydrophilic gels. I-HPMC inokutshitshiswa kwi-Gestric Alweid, ineengenelo ezilungileyo zokucinezelwa, i-squidity elungileyo, i-firring yeziyobisi isetyenzisiwe yi-HYDROphilic Systeres, kwaye isetyenziswa ngokulungiselela i-Hydrophilic ges, kwaye isetyenziswe kwi-Gestric Deageant ye-Interment yeRuble.

Okwesithathu, njengefilimu ehlekisayo-iarhente yokwakha. I-HPMC inefilimu elungileyo, ingenisa iyunifomu yefilimu, ebonakalayo, inzima, imveliso akukho lula ukunamathela, ingakumbi iMveliso yokuQala, ithembisa ungqiniso lwefilimu. I-HPMC ineentlobo ngeengcaciso ezahlukeneyo zokubonisa, ezinje ngokhetho olufanelekileyo, olunomgangatho weefilimu, inkangeleko ingcono kunezinye izinto, ukusetyenziswa kwayo okuxhaphakileyo kwe-2% ~ 10%.

Elesine ifana ne-capsule ye-capsule. Kwiminyaka yakutshanje, ngokuqhambuka okuqhubekayo kwesilwanyana saseburhulumenteni, xa kuthelekiswa ne-gelatin capsules, iicapbules zisiza kuba sisithandwa esitsha se-PARMACEUCOCACY NOKWENZA INDAWO YOKUZIPHATHA. I-PFizer ikhuphe ngempumelelo i-HPMC kwi-HPMC evela kwizityalo zendalo kunye ne-vcapm elungiselelwe i-vipsules. Xa kuthelekiswa ne-gelatini yemveli ye-gelatini, iicapsules zezityalo zinezinto eziluncedo kuzinzo olubanzi, akukho wumbi lokunxibelelana nomngcipheko kunye nokuzinza okuphezulu. Ireyithi yokukhutshwa ngamachiza iqhelene, umahluko umntu mncinci, kwaye akazange afuneke emva kokuba ehluthiwe emzimbeni womntu, kwaye unokukhutshwa emzimbeni ngemigudu. Ngokweemeko zogcino, ngenani elikhulu lovavanyo, iicaphule ziphantse zange zibrittle phantsi kweemeko eziphantsi komswakazi, kwaye iipropathi zecaphus zisazinza phantsi kweemeko eziphezulu zokufuma, kwaye izikhombisi ze-reats azichaphazelekanga phantsi kweemeko zokugcina. Ukuqonda kwabantu iicapbules zezityalo, kunye notshintsho lomqondo weziyobisi loluntu ekhaya nakwamanye amazwe, imfuno yentengiso ye-capsules yokutyala iya kukhula ngokukhawuleza.

Isihlanu siyiarhente yokumiswa. Amalungiselelo olwenziweyo onqunyanyisiweyo aqhele ukusetyenziswa kwiifom ze-dosage zeklinikhi, ezizisasazo ezinolwazi olunzulu lwamachiza angenayo kwi-Insultions kwimithombo yeendaba zokusasazwa kwerediyo. Uzinzo lwenkqubo lubonisa umgangatho wokulungiselela ukumiswa kwamanzi. Isisombululo se-HPMC Colloidal sinokunciphisa ukungqubana kwengqondo eqinileyo, ukunciphisa amandla asimahla samasuntswana amasuntswana, ukuze inkqubo yokusasazeka i-heterogeneous idla ngokuzinza, yiarhente ebalaseleyo. I-HPMC isetyenziswa njenge-thickener yehla, kwaye umxholo ngu-0.45% ~ 1.0%.

Hydroxypropyl seluplose

I-Hydroxypropyl seluplose (HPC) sisifo esinye se-Inser Sether esenziwe kwikotoni kunye neenkuni nge-alkalization, i-propylene oxide kunye nezinye iinkqubo. I-HPC ihlala inyibiliza emanzini ngezantsi kwe-40 ℃ kunye nenani elikhulu leenyawo zepolar. Iipropathi zayo zihambelana nomxholo we-hydroxypropyl kunye nenqanaba le-polymerization. I-HPC inokuhambelana namachiza ahlukeneyo kwaye ine-interia elungileyo.

I-hydroxypropyl ye-hydroplopy ye-phullosel ye-LELDROSE isiphumo esiqhelekileyo.

I-Hydroxypropyl ye-Hydroplopy ye-Hydroplopy ye-SHYDROSE (H-HPC) inokusetyenziswa njenge-binder yethebhulethi, igranile kunye negranti elungileyo kwintsimi yamayeza. I-H-HPC inefilimu egqwesileyo, ifilimu ifunyenwe inzima neli-elastiki, kwaye inokuthelekiswa neplastiki. Ngokuxubana nolunye u-Adal olwamasikiso, intsebenzo yefilimu inokuphuculwa ngakumbi, kwaye isetyenziswa njengokuthintela ifilimu yeetafile. I-H-HPC inokusetyenziswa njengezixhobo zesakhelisi ukuze zilungiselele amacwecwe e-specieds, iipelethi ezikhutshelweyo kunye neetafile ze-windows kabini.

Hydroxyyl seluplose

I-HydroxyEtheetheetheetheetheethy (Hec) i-Inser Sether enye ye-Inser eyenziwe kwikotoni kunye neenkuni nge-alkalization, i-ethylene oxide yokuthintela kunye nezinye iinkqubo. I-hec isetyenziswa ikakhulu njenge-tickener, iarhente yokhuselo, imbethe, isisasazi, iarhente, iarhente yokumiswa, iarhente yefilimu kunye nempahla yokukhutshwa kwezempilo kwicandelo lezonyango. Ingasetyenziselwa ukuvela kwezichiza zasekhaya, ii-oyile, iliso lamehlo, ulwelo lomlomo, iitafile eziqinileyo, iicapbules kunye nezinye iifom zedosi. I-HydroxyEtheetheetheetheethy ifakiwe kwi-United States Pharmacopoeia / I-United States formulary kunye ne-European Pharmacopoeia.

I-Ethyl Selelose

I-Ethyl Selelose (EC) yenye yezona zinto zisetyenziswa kakhulu zesekela. I-EC ayinatyhefu kwaye izinzile, i-infline emanzini, i-acid okanye izisombululo ze-alkali, inyibilikiswe e-ethanol, i-methanol kunye nezinye izinyibilikisi. Izinyibilikisi eziqhelekileyo zingumxube we-toluene / e-ethanol ye-4/2 ngobunzima. I-EC ininzi esetyenziselwa ukwenziwa kwamachiza okukhutshelwa kweziyobisi, isetyenziswa ngokubanzi njengomphathi we-pipsule elawulwayo kunye ne-pill ehleliyo, isetyenziswa njenge-pill ye-skelen, esetyenziswa njengokupakisha kancinci, isetyenziswe njengokulungiswa kwezixhobo ezihamba kancinci khupha i-capsule encinci; Ingasetyenziswa ngokubanzi njengomxholo ophetheyo wokulungiselela ukusasazeka okuqinileyo. Isetyenziswe ngokubanzi itekhnoloji yamayeza njengeyona nto ibonisa ifilimu kunye nokukhusela i-finder, kunye ne-binder kunye ne-filler. Njengoko ukhuselo lweetafile, kunokunciphisa ubuntununtunu beecwecwe zetafile kwi-suididity kwaye kuthintele amachiza ukuba angachaphazeleka ngumanzi kunye nokwazi. Ingakwazi nokukhupha ukukhulula okunamathela ngokuthe ngcembe kwaye icele i-polymer enemicrocaps, ukuze isiphumo seziyobisi sinokukhululwa ngokuqhubekayo.

Siza kususa phakathi kunye nezicelo zokuphela kunye nokukhawulezisa ukutshintsha kunye nokuphuculwa

Ukuqaphela, i-sodium ye-sodium ye-sodium ye-sodium ye-sodium ye-sellyulose, methyl seluplopyl methulose, iarhente ye-exloment ye-Isuplose yeSeluplose yeSeluplose yeSeluplose yeSeluplose yeSeluplose ye-Selly I-filmers formers, i-capsule yecaphule kunye noncedo olunqunyanyisiweyo olusetyenziswayo kwi-suriguils. Ukujonga umhlaba, iinkampani ezininzi zelizwe zamanye amazwe (iJapan Shin-Etsu, i-United States Wolf kwaye i-Ashland) iqaphele intengiso enkulu ye-china kwixa elizayo, okanye yonyuse imveliso kutyalo-mali kule ndawo. I-Dow ibhengeze ukuba iya kuphuma kugxilwe kugxile ekusetyenzisweni, izithako kunye neemfuno zentengiso yamachiza amachiza amayeza, kunye neenzame zayo zokuzisa uphando olusebenzisekayo kwintengiso. I-Dow Selew Selew Seleose kunye nombala webala lezemibala yehlabathi yokusetyenziswa okulawulekayo, kunye nabasebenzi abangaphezu kwe-1,200 kwizixeko ezisetyenziswayo zophando ezisetyenzisiweyo abathengi malunga namazwe ali-160. I-Ashland ineenkqubo zenzala eBeijing, eTianjin, Shanghai, i-nangehai, i-changzhana, i-Kunshan naseJiangmen, kwaye ihlawulwe kumaziko amathathu eetekhnoloji yaseShanghai naseMnanjing.

Ngokwewebhusayithi ye-Chinase Chinase Orther Arther, ngo-2017, imveliso yasekhohlo i-Telulose I-373,000, kwaye ivolumu yokuthengisa yayingama-360,000 iitoni. Ngo-2017, ivolumu yokuthengisa i-Ionic ye-IOIC yayingama-234,000 iitoni, up 18.61% unyaka nonyaka, kwaye on-Ionic CMC yayingu-126,000 ngonyaka. Non-ionic products in addition to HPMC(building materials), HPMC(pharmaceutical), HPMC(food), HEC, HPC, MC, HEMC and so on are bucking the trend and increasing production and sales. I-ete yeselsese yasekhaya ikhule ngokukhawuleza ngaphezulu kweminyaka elishumi, ikhutshiwe ibe yeyokuqala, kodwa uninzi lweemveliso ze-Ether Ither isetyenziswa ngokuyintloko yeshishini, ixabiso elongeziweyo aliphezulu.

Indawo eyahlukeneyo ye-Seleuplose Ether i-Ether i-Ether iShishini kwaye ikwixesha elininzi lenguqu kunye nokuphuculwa kwentengiso yemveliso, isebenzise ishishini lehlabathi, kwaye isebenzise ishishini lokuphucula ishishini kunye nophuhliso kuphuhliso oluluhlaza noluhlaza.