Yintoni ixabiso le-pH ye-HPMC?

Ixabiso le-pH le-HPMC (i-hydroxypropyl methylcelceltulose) ixhomekeke kuxinzelelo lwayo kwisisombululo, ubushushu, kunye nomgangatho kunye nokucoceka kwamanzi asetyenzisiweyo. Ngokwesiqhelo, ukubaluleka kwe-HPMC kwisisombululo esibonakalayo siphakathi kwe-5.0 ne-8.0, kuxhomekeke kwiimeko zokuchitha kunye neenkcazo ezinikwe ngumenzi.

1. Iipropathi ezisisiseko ze-HPMC
I-HPMC yi-ionic ye-ionic selsulose ebonakalayo esetyenziswayo kwindawo yamayeza, yokutya kunye nemizi-mveliso ye-cosmetic, eneefilimu zefilimu, ukuqina kunye nokuzinza. Ayingo-Ionic, inyibilikiswe emanzini abandayo kodwa hayi emanzini ashushu, kwaye isisombululo singathathi hlangothi okanye sine-acidic kancinci. Kwizicelo zemizi-mveliso, i-HPMC yamkelekile ngokubanzi ukhuseleko lwayo kunye nezinto ezizinzileyo.

2. Uluhlu lwe-HPMC Act
Ngokwedatha yelebhu kunye nexabiso loncwadi, ixabiso le-HPMC kwizisombululo ezigxila kakhulu (ezinje nge-1-2%) ngokubanzi phakathi kwe-5.0 kunye ne-8.0. Imiyalelo yemveliso enikezwe ngumenzi idla ngokunika uluhlu lwe-PH olufanayo kubasebenzisi ukuba babhekise kwinkqubo yomiselo. Umzekelo, ukuxabiseka kwe-pH zeemveliso ezithile ze-HPMC kwi-0.1% yesisombululo se-ACTEOROAROOR simalunga ne-5.5 ukuya kwi-7.5, esikufuphi kakhulu ekungathathi cala.

Isisombululo esiphantsi sobuso

Isisombululo esiphezulu sokugxininisa: Kwingcinezelo ephezulu, i-velosity yesisombululo inyuka, kodwa ixabiso le-pH lisaqhubeka nokungathathi cala.

Iziphumo zobushushu: Ukunyibilisela i-HPMC kuchaphazeleka kakhulu ngamaqondo obushushu. Inyibilika ngokulula emanzini abandayo kwaye iphinde icinezelwe ngokulula kumanzi obushushu aphezulu. Xa ulungiselela isisombululo se-HPMC, ihlala icetyiswa ukuba isebenzise amanzi abandayo ukuthintela utshintsho olwenziwayo olubangelwa bubushushu obuphezulu.

3. Ukuboniswa kwexabiso le-PH kunye nefuthe lezinto zokuphembelela
Ngokwesiqhelo, ngexesha lokuvelisa kunye nokusetyenziswa, xa kuhlolwe ixabiso le-HP le-HPMC Ascound, i-pp ecocekileyo isetyenziselwa umlinganiso ngqo. Nangona kunjalo, ezi zinto zilandelayo zichaphazela iziphumo zomlinganiso:

Ukucoceka kwamanzi: Amanzi avela kwimithombo eyahlukeneyo anokuqulatha izitya, iiminerali, njl njl. Kuyacetyiswa ukusebenzisa amanzi e-deion okanye amanzi axhonywe ukulungiselela isisombululo se-HPMC ukuqinisekisa ukuchaneka kweziphumo.
I-Sombulelo: Ukuphakathi kwe-HPMC, okukhulu kwe-viscosity yesisombululo, ezisa ubunzima obuthile kwimilinganiselo ethile, ngenxa yokuxinana okuphantsi (<2%) kusetyenziswa ngokubanzi.
Imeko yangaphandle: Ubushushu, ubungakanani bezixhobo zokulinganisa, njl. Njl.

I-4. Iimfuno ze-hle kwimo yesicelo se-HPMC
Xa i-HPMC isetyenziswa ekutyeni neyeza, uzinzo lwayo kunye nokuguquguquka kwe-pH kufuneka kuqwalaselwe. Umzekelo, kwiitafile zamachiza kunye namalungiselelo e-capsule, i-HPMC isetyenziswa njenge-thiyiclener, iarhente yokukhutshwa-khupha kunye nokuzinza, kunye nozinzo zePH Uninzi lweziyobisi kufuneka zikhutshwe kwindawo engathathi cala okanye kancinci i-acidic, ke iimpawu ze-HPMC zilungele le njongo.

Umzi-mveliso wokutya: Xa i-HPMC isetyenziswa njenge-gickener kunye ne-stabilizer, ihlala inethemba lokuba ixabiso le-PH likufuphi nokungathathi hlangothi kunye nokuzinza kwemveliso.
Ishishini lamachiza: kwiitafile kunye ne-capsules, i-HPMC isetyenziselwa ukulawula ukukhutshwa ngamachiza, kunye nesitali esisondeleyo kunceda ukugcina umsebenzi wechiza.

5. Indlela yohlengahlengiso lwe-PH ye-HPMC ACTEAUR
Ukuba ixabiso le-pH lesisombululo se-HPMC kufuneka sitshintshwe kwisicelo esithile, sinokuhlala sibolile ngokongeza i-acid okanye ialkali. Umzekelo, isixa esincinci se-dilute shyrochloric acid okanye isisombululo se-sodium hydroxide sinokusetyenziswa, kodwa kufuneka silawuleke ngononophelo ukuthintela ukugqitha kuluhlu lwe-HPMC.

Ixabiso le-pH le-HPMC kwisisombululo esinamandla liphakathi kwe-5.0 ne-8.0, elikufutshane necala lokungathathi cala. Iimfuneko ze-PH zeemeko ezahlukeneyo zesicelo zinokwahluka kancinci, kodwa zihlala kungafuneki kohlengahlengiso olukhethekileyo.