Nguwuphi umahluko phakathi kwe-methylcelceluplose kunye ne-HPMC?

I-Methyl Selelose (MC) kunye ne-hydroxypropyl methylcelcelsulose (i-HPMC) zizo zombini iiSelulose (HPMC) zizo zombini ezi ziselsulose kwaye zisetyenziswa kakhulu kwiindawo zamayeza, ukutya, izinto zokwakha kunye nezinye izinto. Nangona bobabini bavela kwiseli yemvelo kwaye babenemisebenzi efanayo kwizicelo ezithile, banomahluko obonakalayo kwimo yemichiza, iipropathi zomzimba, amasimi esicelo kunye neempawu ezisebenzayo.

I-1. Ubume kunye nenkqubo yokulungiselela
I-Methyl Selelose (MC): I-Methyl Selelose iveliswa ngokutshintsha icandelo okanye onke amaqela e-hydroxyl (--) ye-seluplose kunye namaqela e-APLXY (-och₃). Ngokukodwa, amaqela e-hydroxyl kwi-seluplose asabela nge-Rethylating Regegents (njenge-methyl chloride) phantsi kweemeko ze-alkaline ukuvelisa i-METHylceluplose. Ngenxa yamanqanaba ahlukeneyo okufaka endaweni, i-MC inokuba nomoya ohlukileyo kunye nokubonisa.

I-HydroxyPOpyl Methylcelcelculose (HPMC): I-HPMC iphinde yaguqulwa ngakumbi kwi-MC, oko kukuthi, kwi-molecule ye-selselose ithathelwe indawo yeqela le-hydroxyl) Ulungiselelo lwe-HPMC lubandakanya indlela yokuphendula emibini Ngenxa yoku kufaka indawo kabini, iipropathi ze-HPMC zintsonkothile kwaye ezahlukeneyo.

I-2. Ukungasebenzi kunye neepropathi zomzimba
Ukususwa kwe-MC: Methylcelcelculose inesifo esihle emanzini abandayo, kodwa ayinyibili amanzi ashushu. Isisombululo sayo siya kuvelisa i-phenomenon yejeno xa ifudumele, nto leyo eyenza i-MC inexabiso elikhethekileyo lokwenza izinto, ezinjengokusetyenziswa kwayo kwizinto zokwakha.

Ukususwa kwe-HPMC: Ngokwahlukileyo, i-HPMC inyibilikisa kumanzi abandayo nashushu, kwaye izisombululo zayo zinoluhlu olubanzi lwe-viscofity. Ukongeza, i-HPMC ibonakalisa uzinzo oluhle kwizisombululo ezikhutshekileyo kwaye ayinantlonelo kutshintsho kwixabiso le-pH, ngoko ke isetyenziswe ngokubanzi kumashishini amayeza kunye nokutya.

3. Iindawo zesicelo
Ukusetyenziswa kweMethylcelculose: Ngenxa yepropathi ye-thermalgeng ye-MC, ihlala isetyenziswa njenge-arhente yokugcina amanzi kunye nemveliso yokwakha, njl njl, njl njl. Kumzi-mveliso wamachiza, i-MC ngamanye amaxesha isetyenziswa njengearhente yetafile kunye nezinto zokwenza ifilimu zeecapsules.

Ukusetyenziswa kwe-HydroxyPOpyl Methylcelceluplose: I-HPMC iguquguqukayo kune-MC kwimizi-mveliso emininzi ngenxa yokulimala kwane ngokubanzi kunye nokuzinza. Umzekelo, i-HPMC isetyenziswa ngokubanzi kumzi-mveliso wamayeza ukuze ilungiselele iitafile zokukhutshwa kwe-capsule kunye ne-capsule ye-capsule, kunye ne-thiad kunye neoyile ye-Ophthalmic. Kwizixhobo zokwakha, i-HPMC ihlala isetyenziswa njenge-tickener kunye nearhente yokugcina amanzi, i-preties kunye nemikhono. Ukongeza, i-HPMC ikwasetyenziswa njenge-thi chuker, i-enulsifier kunye nokuzinza kumzi-mveliso wokutya.

I-4. Iimpawu zomsebenzi kunye nohluko wentsebenzo
Iimpawu eziSebenzayo zeMC: Inqaku elahlukileyo le-methylcelculose ziipropathi zalo zokuthengisa, ezenza ukuba isebenze ngokukhethekileyo kwizicelo ezifuna ukuzinza kwe-thermal. Ukongeza, isisombululo se-ACC esine-MC sinomgangatho othile wobumfihlo kunye nomsebenzi womphezulu, oluncedo kwiinkqubo ezithile zemizi-mveliso.

Iimpawu eziSebenzayo ze-HPMC: i-Hydroxylypropy ye-methylcelcelcelose ibonakaliswa kukulawulwa kwalo lomoya kunye ne-vissosity yesisombululo, kunye nokuzinza kwaso kubushushu kunye ne-PH. Ezi mpawu zenza ukuba i-HPMC ibonisa ukuba bhetyebhetye kakhulu kunye nokuzinza kwizicelo ezahlukeneyo. Ukongeza, i-biocomatisi ye-HPMC kunye netyhefu yenze ukuba kubaluleke kakhulu kumashishini ezonyango kunye nokutya.

I-5. Ukukhusela kwendalo kunye nokhuseleko
Iipropathi ezinobuhlobo bendalo ye-MC kunye ne-HPMC: Njenge-selselese i-sellese, i-MC kunye ne-HPMC yimisebenzi enokusetyenziswa kwendalo kwaye ichaphazela impembelelo engqongileyo kwindalo esingqongileyo. Ukongeza, zombini ezona zinto azinetyhefu, zingacaphuki kwaye zikhuseleke kakhulu, zibenza balungele ukusetyenziswa kwiindawo ezinemisebenzi eneendlela eziphezulu zomntu, njengokutya neyeza.

Although methylcellulose (MC) and hydroxypropylmethylcellulose (HPMC) have similarities in chemical structure, their solubility, physical properties, application fields and functional characteristics are different due to different substituents. Kukho umahluko obonakalayo. I-MC ikakhulu idlula kwizicelo ezifuna iipropathi ze-thermals, njengakwizinto zokwakha; Ngelixa i-HPMC isetyenziswe ngokubanzi kwindawo yamayeza, ukutya kunye namashishini okwakha ngenxa yomhlaba obanzi, uzinzo kunye nokungabinamandla. Ukuqonda umahluko phakathi kwezi zimbini kunokukunceda ukhethe eyona nto ifanelekileyo kwisicelo esithile.