Yintoni umahluko phakathi kwe-HPMC kunye ne-MC kwizicelo zamachiza?

I-HydroxyPOpyl Methylcelcellulose Ngaphandle kokufana kwazo, baneempawu ezizodwa kwimo yemichiza, iipropathi kunye nokusetyenziswa okubenza bafaneleke kwiinjongo ezahlukeneyo kumzi-mveliso wamayeza.

Ubume bekhemikhali kunye nolwakhiwo
Hydroxypropyl methylcelceltulose (HPMC):

I-HPMC yi-cutyuesid ye-headsese eguqulweyo. Ithathwe kwi-seluplose ngokuthatha i-methyl chloride kwaye i-proplene oxide, eyazisa i-PACESSY (-OCH3) kunye ne-HydroxyPOpyl (-C2chohch.) Inqanaba lokufakwa endaweni (DS) kunye ne-molar I-DS imele inani eliqhelekileyo lamaqela e-hydroxyl athathwe kwiyunithi ye-anhydroglucose nganye, ngelixa i-MS ibonisa inani eliphezulu lamaqela e-hydroxypropy eqhotyoshelwe.

Methylcellulose (MC):

I-MC lelinye i-selupelose ether, kodwa iguqulwe kancinci xa kuthelekiswa ne-HPMC. Iveliswa ngokunyanga isellulose ne-methyl chloride, ikhokelela ekufakweni kwamaqela e-hydroxyl ngamaqela e-Masxy. Olu hlengahlengiso luyenziwa ngenqanaba lokufakwa endaweni Ukungabikho kwamaqela e-hydroxypropy kwi-mc ukwahlula ukusuka kwi-HPMC.

Iipropathi zomzimba
Ukungabilili kunye negexola:

I-HPMC inyibilikiswa kumanzi obandayo kwaye ashushu, esenza isisombululo seColoidal. Emva kokufudumeza, i-HPMC ifumana ingqumbo enokuqina, intsingiselo iyenza ijeli xa ishushu kwaye ibuyela kwisisombululo xa kupholile. Le ndawo iluncedo kakhulu kukhululwe iziyobisi olawulwayo kwaye njenge-viscofity yosulelo kwizisombululo ze-accound.

I-MC, kwelinye icala, inyibilikisa emanzini ebandayo kodwa i-insulard ngamanzi ashushu. Ikwabonisa ne-thermoe; Nangona kunjalo, ubushushu bayo bokuhluthi bungaphantsi kakhulu kune-HPMC. Olu phawu lwenza ukuba i-MC ifaneleke kwizicelo ezithile zamayeza apho amaqondo obushushu asezantsi ayaluncedo.

I-Viskosity:

Zombini i-HPMC kunye ne-MC zinokunyusa kakhulu i-viscofity yezisombululo zezezisombuso, kodwa i-HPMC ngokubanzi ibonelela ngoluhlu olubanzi lweendlela ezahlukeneyo zokufakwa endaweni yakhe. Olu hluko luvumela ulawulo oluthe ngqo kwiziko elifuna iiprofayili ezithile ze-viscofity.

Umsebenzi kwiPhemaceuticals
I-HPMC:

Ifomu elawulwa i-matrix:
I-HPMC isetyenziswa ngokufanelekileyo kwifomu ye-matrix. Ukukwazi kwayo ukudumba kwaye wenze i-gel fayile kunxibelelwano kunye nolwelo lwe-gastric lunceda ukulawula inqanaba lokukhutshwa kweziyobisi. I-Gel Faker isebenza njengesithintelo, ukulinganisa ukwahluka kwechiza kunye nokukhulula ukukhutshwa kwayo.

Ifilimu yefilimu:
Ngenxa yepropathi yayo yefilimu yefilimu, i-HPMC isetyenziswa ngokubanzi kwi-capings kunye neepellets. Inika umqobo okhuselayo ngokuchasene nokufuma, ioksijini, kunye nokukhanya, ukuphucula ubomi bozinzo nobomi bemveliso. Ukongeza, iingubo ze-HPMC zinokusetyenziselwa ukungcamla imaski kunye nokuphucula ukubonakala kweetafile.

I-Binder kwiFowuni yeTafile:
I-HPMC ikwaqeshwa njenge-Binder kwiinkqubo ze-grannings. Iqinisekisa amandla oomatshini beetafile, ukuqhubela phambili ukubopha kwamasuntswana epolayo ngexesha lokucinezelwa.

Ukumisa kunye nearhente yokuthambisa:
Kwifomu engamanzi, i-HPMC isebenza njengearhente yokumisa kunye nearhente yokuthambisa. UVenkile lwayo oluPhakamileyo lunceda ekugcineni ukusasazwa okungafaniyo kwamasuntswana anqunyanyisiweyo kwaye kuphucula ukungqinelana kokuqulunqwa.

Mc:

Ithebhulethi yokubopha:
I-MC isetyenziswa njenge-binder kwifom yetafile. Inika iipropathi ezilungileyo zokubopha kunye namandla omatshini kwiitafile, ukuqinisekisa ukuthembeka kwabo ngexesha lokugcina nokugcina.

Intsholongwane:
Ngamanye amaxesha, i-MC inokusebenza njenge-suintergorn, inceda amacwecwe amacwecwe ukuze ahlukane namaqhekeza amancinci xa edibana nolwazelelelo ngeenxa zonke, ngaloo ndlela eququzelela ukukhutshwa ngamachiza.

Ifomu yokukhutshwa elawulwayo:
Nangona incinci into engaqhelekanga kune-HPMC, i-MC inokusetyenziswa kwifom yokukhutshwa elawulwayo. Iipropathi zayo zokuhambisa i-thermoge zinokuxhatshazwa ukulawula iprofayili yokukhululwa kweziyobisi.

Iarhente yokuthambisa kunye nokuzinzisa:
I-MC isetyenziswa njenge-arhente yokuthambisa kunye nokuzinzisa kwi-arhente yokuzinzisa kubulala kunye neefomu ezikhululekileyo. Ukukwazi kwayo ukwandisa i-viscofity kuyanceda ukugcina uzinzo kunye ne-homogeneity yemveliso.

Izicelo ezithile kwi-PHMACEOTICS
Izicelo ze-HPMC:

Amalungiselelo e-Ophthalmic:
I-HPMC ihlala isetyenziswa kwizisombululo ze-Ophthalmic kunye neegesi ngenxa yepropathi yayo ye-vibleating kunye ne-viscoelastic. Inika ukugcinwa komswakama kwaye yandisa ixesha lokunxibelelana lechiza kunye nomgangatho we-ocular.

Iinkqubo zokuHanjiswa kweTransdal:
I-HPMC iqeshwe kwiipasile eziguqukayo apho ubuchule bokwenza ifilimu kuyanceda ukudala ukukhululwa kwematrix yokuhanjiswa kwamachiza ngolusu.

I-MUCOADERORTES:
Iipropathi ze-MUICMADHEATIDs ze-HPMC zenza ukuba kubekho i-zucccal, i-nasal, kunye neenkqubo zobufazi, ekwaziyo ixesha lokuhlala lokuqulunqwa kwendawo yokufaka isicelo.

Izicelo ze-MC:

Ifomu ePhezulu:
I-MC isetyenziswa kwizikhrim eziphezulu, iigesi, kunye ne-oftiments apho isebenza khona njenge-arhente yokuthambisa nokuzinzisa, ukuphucula ukusasazeka kunye nokungaguquguquki kwemveliso.

Ukutya kunye neSondlo:
Ngaphaya kwamayeza, i-MC ifumana izicelo kwizicelo zokutya kunye nesondlo njenge-thicraceutical njenge-thi chulener, i-enulssifier, kunye nokuzinza, igalelo ekutshoneni kunye nokuzinza kweemveliso ezahlukeneyo.

Kwisishwankathelo, i-HPMC kunye ne-MC zizibini ezibalulekileyo zesellulose ezineempawu ezahlukileyo ezenza bafaneleke kwizicelo ezahlukeneyo zamayeza. I-HPMC, kunye nokuthobeka kwayo kabini kumanzi ashushu kunye obandayo, uluhlu oluphezulu lwe-viscofity, kunye nezakhono zokwenza ifilimu, zibalelwa ikakhulu kwifomu yokukhutshwa kwefilimu, itayitile yetafile, kunye namalungiselelo e-ophthalmic. I-MC, ngelixa ilula ngokuyila, inika izibonelelo ezizodwa ezizodwa kunye namaqondo obushushu aphantsi, esenza ukuba kube lula njengommeli, intsholongwane, kunye nearhente yokuthambisa kwizicelo ezithile. Ukuqonda umahluko kwiziko labo lezikhemikhali, iipropathi zomzimba, kunye nokusebenza kuvumela izixhobo zokukhetha i-selsuloese efanelekileyo yokufikelela kwiimfuno ezithile zeemveliso ezithile zamachiza.