Ukugweba umgangatho we-hydroxypropyl methyl seluplose

I-HydroxyPOpyl Methyl Selelise (HPMC) yi-polymer eguquguqukayo efumana ukusetyenziswa okukhulu kumashishini ahlukeneyo, kubandakanya amayeza aphezulu, ukwakhiwa, ukutya, kunye nangaphezulu. Izicelo zayo ezahlukeneyo zivela kwiipropathi zayo ezizodwa, ezinjengamandla okwenza ifilimu, amandla okutsala, iipropathi ezibophelelayo, kunye neempawu zokugcina amanzi. Umgangatho we-HPMC ubalulekile ekuqinisekiseni ukusebenza kunye nokhuseleko lweemveliso ezisetyenziswayo.

1.Ukulongezelelo:
Ukuqulunqwa kwamachiza kwe-HPMC kubaluleke kakhulu kumgangatho wayo. I-HPMC yindawo yokukhutshwa kweselutase, iguqulwe nge-hydroxypropy kunye neenkqubo zemazi. Inqanaba lokufakwa endaweni Iinqobo eziphakamileyo ze-DS ngokubanzi zikhokelela ekunyukeni kokungasebenzi kwamanzi kunye nokuncipha kweqondo lokuhlaselwa. Iindlela zohlalutyo ezifana nokufumana i-nuclener realnic (NMR) i-Spectrascopy kunye ne-infrared (ir) ye-IR) isetyenziswa ngokuqhelekileyo ukumisela ubume bekhemikhali kunye ne-DS yeesampulu ze-HPMC.

2.Ukucinezela:
Ukucoceka yinxalenye ebalulekileyo yomgangatho we-HPMC. Ukungcola kunokuchaphazela ukusebenza kunye nokuzinza kweemveliso. Ukungcola okuqhelekileyo kubandakanya izinyibilikisi ezintsalela, izinyithi ezinzima, kunye nokungcoliseka kwentsholongwane. Iindlela ezahlukeneyo zokuhlalutya ezifana ne-chromatography ye-chromatography ye-chromatography (i-HPPC), i-chromatography (igesi) isetyenziselwa i-plasma-Mass Specture (ICP-MS) isetyenziswa ukuvavanya ubunyulu beesampulu ze-HPMC.

Isisindo se-3.molecular:
Ubunzima be-phudm ye-HPMC iphembelela iipropathi zayo ze-propelocal, zodwa, kunye nobuchule bokwenza ifilimu. Ubunzima obuphezulu be-rolecular i-HPMC uqhekeza i-viscofity enkulu kunye namandla eefilimu. I-gel promation chromatography (GPC) yindlela esetyenzisiweyo esetyenzisiweyo yokuchonga isampulu yesiqhelo ye-HPMC.

4.1
UVICWASITY yiparamitha ebalulekileyo yomgangatho we-HPMC, ngakumbi kwizicelo ezifana nefomu yobume bemihlaba, apho isebenza njengearhente yokuthambisa. UVenkile weZilungitho ze-HPMC uyachaphazeleka ngezinto ezinje ngoxinzelelo, ubushushu, kunye nenqanaba le-Shear. Iindlela ezahlukeneyo zokubonisa izinto zokubonisa, kubandakanya ukuvimba okujikelezayo kunye nokuboniswa kwe-capillary, baqeshe ukulinganisa isisombululo se-HPMC kwiimeko ezahlukeneyo.

5.phutha umxholo womswakama:
I-PH kunye nokufuma kwe-HPMC kunokuba nefuthe kuzinzo lwayo kunye nokuhambelana nezinye izithako kwifomu. Umxholo womswakama kubaluleke kakhulu njengokufuma kakhulu umswakama kunokukhokelela ekukhuleni kwentsholongwane kunye nokonakaliswa kwe-HPMC. Isibali-mali se-Karl Sisetyenziswa sisetyenziselwa ukumisela umxholo wokufuma, ngelixa iimitha ze-PH ziqashwe kwi-PH.

6.Partarcle ubungakanani kunye ne-morphology:
Ubungakanani bentsumpa kunye ne-morphology idlala indima ebalulekileyo kwipropathi yokuhamba kunye nokusasazeka kweepowule ze-HPMC. Iindlela ezifana ne-Laser I-Elergy Sconscopy (i-SOF) isetyenziswa ukuhambisa ubungakanani bobungakanani kunye ne-morphology yamasuntswana e-HPMC.

7.Umthetho:
Iipropathi ze-thermal ezinjengee-Gartions zeglasi (i-TG) kunye nobushushu bobuqhetseba obujikelezayo zibonelela ngokuqonda kwiimeko zokuzinza kunye nokulungisa iimeko ze-HPMC. I-calolostial scanment yekhefu (i-DSC) kunye nohlalutyo lwe-thermographimpric (i-TGA) isetyenziselwa ukuhlalutya i-thermal yesampulu ye-HPMC.

8.Ukuvota kunye nefilimu:
Kwizicelo ezifuna ukwenziwa kwejeli okanye ukuqulunqwa kwefilimu, ubushushu be-gesing kunye neepropathi zokwenza ifilimu ze-HPMC ziiparameter ezibalulekileyo. Imilinganiselo ye-RTouological kunye neemvavanyo zokwenza ifilimu zenziwa ukuvavanya ezi ndawo ziphantsi kweemeko ezifanelekileyo.

Ukuvavanywa komgangatho we-hydroxypropyl methyl seluplose (i-HPMC) kubandakanya uhlalutyo olubanzi lwekhemikhali, ukucoceka, ubunzima bemolekyuli, ubungakanani bemisitho, kunye nokusebenza kwe-thermal, kunye nokwenziwa kweempawu ezifana nokuhlelwa. Iindlela ezahlukeneyo zohlalutyo zisetyenziswa ukuvavanya ezi parameter, ukuqinisekisa ukuba i-HPMC ihlangabezana nenkcazo efunekayo kwizicelo zayo. Ngokugcina imigangatho ephezulu, abavelisi be-HPMC banokuqinisekisa ukusebenza, ukhuseleko, kunye nokusebenza kweemveliso kumashishini ahlukeneyo.