Kufundisa ngeendlela ezininzi zokujonga umgangatho we-hydroxypropyl methylceluplose

I-HydroxyPOpyl Methylcelcelsulose (HPMC) yi-Polymer Polymer ye-Polymer esetyenziswayo esetyenziswayo kwiindawo zamayeza, ukutya, izinto zokwakha kunye namanye amasimi. Umgangatho womgangatho wayo uchaphazela ngqo ukusebenza kunye nokuzinza kwemveliso.

1. Imbonakalo kunye nombala
Inkangeleko kunye nombala zizinto zangaphambili zokuvavanya umgangatho we-hydroxlyproptl methylceluplose. Umgangatho olungileyo i-HPMC ihlala imhlophe okanye i-off-whider emhlophe enento efanayo kunye ne-octure. Umbala awufanelanga ukuba ityheli, i-brown okanye nayiphi na imibala engaqhelekanga, enokubangelwa kukonakala okubangelwa zizinto ezinqabileyo okanye ukugcinwa okungafanelekanga ngexesha lenkqubo yokuvelisa. Ukuba umbala ungaqhelekanga, inokubonisa ukuba kukho ingxaki kwi-batch yeemveliso kunye novavanyo olungaphezulu olufunekayo.

I-2. I-powder paund
Ubungakanani bobungakanani bentsumpa yenye yezona zinto zibalulekileyo ekuvavanyeni umgangatho we-HPMC. I-HPMC yomgangatho olungileyo ihlala inobukhulu obuninzi. Amanqanaba amakhulu kakhulu okanye amancinci amaninzi aya kuchaphazela isothungela kwaye isebenze kwizicelo ezisebenzayo. Ubungakanani be-istiyele bunokuhlaziywa ngokuhlala okanye ubungakanani be-suremer. Amasuntswana amakhulu kakhulu anokukhokelela kumothuko olugwenxa kwaye achaphazele i-viscofity yalo kunye nokufana kwayo. Iinkqubo ezahlukeneyo zokugaya zingasetyenziswa kwimveliso ukulawula ukuhanjiswa kwamasuntswana ukuqinisekisa ukuba i-HPMC inokwenza ngokugqibeleleyo isicelo.

I-3. Ukuzalwa kwamanzi kunye nexabiso lokuchitha
Ukuzenzela amanzi i-HPMC yisalathiso esibalulekileyo sokuvavanya umgangatho wayo. Ukunyibilisela kwalo kudla ngokuchaphazeleka yinto yemolekyuli kunye nenqanaba lokufakwa endaweni ye-hydroxyl kunye namaqela e-methyl. I-HPMC ephezulu ye-HPMC inokunyibilikisa ngokukhawuleza emanzini ukwenza isisombululo esibonakalayo nesingenisayo. Ukuvavanya ukuzongezwa kwamanzi, inani elithile le-HPMC linokongezwa emanzini, lifungelwe kubushushu obuthile, kunye nesantya sokutshata kunye nokufana kwayo emva kokupheliswa. Ukuba iyanyibilikisa kancinci okanye ivelise amagqabantshintshi angena-inflene, kusenokwenzeka ukuba umgangatho we-HPMC akazange aqiniseke.

4. Uvavanyo lwe-viscosity
I-viscosity ye-HPMC sisibonisi esiphambili sentsebenzo yomgangatho wayo, ngakumbi xa isetyenziswa njenge-thicker, iarhente okanye iarhente yeGeulsifier. I-Viscosity ihlala ihambelana nobunzima bemolekyuli kunye nenqanaba lokufakwa endaweni ye-HPMC. Uhlobo lwayo lunokuvavanywa ngumdlalo wokuhambisa amanzi okanye i-rheometer ukuba ivavanye iipropathi zayo. Ngokufanelekileyo, i-viscosity ye-HPMC kufuneka zizinzile ngaphakathi kuluhlu oluthile ukuqinisekisa ukusebenza kwalo kwizicelo ezahlukeneyo.

Xa kuvavanywa i-viscofity, i-HPMC kufuneka ichithwe kuxinzelelo oluthile lwamanzi, iqondo lobushushu kufuneka lilungiswe, kunye neepropathi ze-ROOOOIORTE zesisombululo kumazinga okwahlukeneyo kufuneka balinganiswe. Ukuba i-viscosity ingenangaphezulu, inokuchaphazela ukusebenza kwe-HPMC, ngakumbi kwizicelo ezifunekayo kwimfuno ephezulu.

I-5. Ukuzimisela kwenqanaba lokufaka endaweni
Inqanaba lokufakwa endaweni (DS) libhekisa kwinani le-hydroxypropy kunye namaqela e-methyl kwi-HPMC Muleccule. Inqanaba lokufakwa endaweni ichaphazela ngqo isolula, i-viscosity kunye nezinye iipropathi zomzimba kunye neekhemikhali. Iindlela zobuchule ezinje nge-infrad spectroscopy (fir) okanye i-birnetic realnance (NMR) zihlala zisetyenziselwa ukuhlalutya umxholo we-methyl kunye ne-hydroxypropy kwiimolekyuli ze-HPMC.

I-HPMP ekumgangatho ophezulu we-HPMC, inqanaba lokufakwa endaweni kufuneka libe ngaphakathi kuluhlu oluchaziweyo. Iphezulu kakhulu okanye iphantsi kakhulu isidanga sokufaka endaweni yokusebenza esingazinzanga kwaye ichaphazele umgangatho wemveliso yokugqibela. Umzekelo, kakhulu iMethyl

I-6. Ukuzimisela komxholo womswakama
Umxholo wokufuma yenye yezona zinto zibalulekileyo ezichaphazela umgangatho we-HPMC. Eyona nto iphambili kumsitho womswakama kunokubangela imveliso ukuba ibe yimveliso ye-deiquesce kunye ne-agglomerate, ngaloo ndlela ichaphazela intsebenzo yayo. Umxholo wokufuma bumiselwe ngokongeza ukomisa okanye isibali-mali seKarl. Umxholo wokufuma kwe-HPMC ekumgangatho ophezulu kufuneka ungabi ngaphantsi kwe-5% ukuqinisekisa ukuba umgangatho wayo awutshintshi ngexesha lokugcina kunye nokusetyenziswa.

7. Uvavanyo lwe-PH
Ixabiso le-pH yesisombululo se-HPMC likwanguphawu olubalulekileyo lomgangatho wayo. Isisombululo se-HPMC kufuneka sibe nexabiso elizinzileyo, ngokubanzi phakathi kwe-4.0 ne-8.0. Izisombululo ze-acidic okanye i-alkaline izisombululo zinokuchaphazela uzinzo kunye nomsebenzi wayo kwisicelo. Ixabiso le-pH linokugqitywa ngokulinganisa ngokuthe ngqo i-PH yesisombululo isebenzisa i-PH.

8. Uvavanyo lwe-microbiological
I-HPMC yiyonwabile isetyenziswa ngokufuthi isetyenziswa kumashishini amayeza kunye nokutya, kwaye ungcoliseko lwalo lokutya ludinga ingqalelo ekhethekileyo. Ungcoliseko lwe-Microfial aluchaphazeli ukhuseleko lwemveliso, kodwa kunokubangela ukuba imveliso inzisikitye okanye inzi ngokusebenza. Uvavanyo lwentsholongwane lunokwenziwa ngenkcubeko, i-PCR nezonye iindlela ukuqinisekisa ukuba imigangatho yempilo ye-HPMC ihlangabezana neemfuno zemigaqo efanelekileyo.

9. Uhlalutyo lwe-thermogravictric (i-TGA) kunye ne-calolortial yekhefu (i-DSC)
Uhlalutyo lwe-thermovimthertic (i-TGA) kunye ne-calolortial crenaloring (i-DSC) inokusetyenziselwa ukufunda uzinzo lwe-HPMC kunye neempawu zayo zokungazithembi ngexesha lokufudumeza ngexesha lokufudumeza. Ezi ndlela zinokufumana idatha ebaluleke kangaka njengokuphulukana nobunzima, indawo yokunyibilika, kunye neqondo lokushisa leglasi ye-HPMC kwiqondo lobushushu elahlukileyo ukunceda ukuba ihambelane neemfuno ezithile zesicelo.

I-10. Ukuzimisela kwe-chloride umxholo
Ukuba i-HPMC iqulethe i-hloride kakhulu, iya kuchaphazela isothungela kunye nozinzo kwisicelo. Umxholo wayo we-chloride unokumiselwa ngefotometmery yeflakisi okanye isivakalisi se-potenometric. Umxholo we-chloride we-HPMC ngomgangatho olungileyo kufuneka ulawulwe ngaphakathi kuluhlu oluthile ukuqinisekisa ukhuseleko lwayo kunye nokusebenza kwayo.

Ezi ndlela zilapha ngasentla zinokuphinda zivavanye umgangatho we-hydroxypropyl methylceluplose, kubandakanya imbonakalo, ukunyibilikisa, i-visasity, umxholo wokufaka kunye nezinye iimpawu. Izicelo ezahlukeneyo zineemfuno ezahlukeneyo ze-HPMC, ke xa kuvavanywa umgangatho wayo, kubalulekile ukwenza uvavanyo olubanzi ngokudibeneyo neemfuno zemimandla ethile yesicelo. Ezi ndlela zovavanyo zinokuqinisekisa uzinzo, ukusebenza kunye nokhuseleko lweemveliso ze-HPMC, ekuboneleleni ngesiqinisekiso sesicelo sabo.