Indlela elula yokuchonga ye-hydroxypropyl methylcelsele (hpmc)

I-Hydroxypropyl Methylcelcelsulose Inamandla amakhulu okulinganisa amanzi, i-collodal yepropathi kunye nozinzo, ngenxa yoko inesicelo esibalulekileyo kumashishini ahlukeneyo. Ukuze kuqinisekiswe umgangatho wayo nobunyulu, isazisi esifanelekileyo siyimfuneko. Oku kulandelayo ziindlela ezininzi zokuzazisa ezilula ze-hydroxypropyl methylcelculose (i-HPMC), egubungela imiba efana nembonakalo, ukunyibilikisa, i-slicrad spection kunye nempendulo yemichiza.

1. Ukuqwalaselwa kwembonakalo
I-HPMC ihlala i-white umgubo-emhlophe okanye isixhobo segrantila, engenantlonelo kwaye ayinantsingiselo. Ngokujonga inkangeleko yayo, unokulawula ngokuqonda ukuba ingaba i-HPMC enyulu. Naluphi na utshintsho lwemibala okanye ubukho bokungcola kunokubonisa ukuba isampulu ayingcolisi okanye ingcolisekile.

2. Ukuchongwa kwe-solbing
I-HPMC inoliseko olungileyo, ingakumbi emanzini. Beka isixa esincinci sesampulu emanzini kwaye uvuselele ngobunono. If it can dissolve quickly and form a uniform colloidal solution, it means that the sample is hydroxypropyl methylcellulose. Isantya sokupheliswa kunye nokugcinwa kwesisombululo kunokuhambelana nobunzima be-HPMC kunye nomxholo we-hydroxypropy kunye ne-methyl yemichiza.

Kwangelo xesha, i-sloubihelity ye-HPMC kwi-owels yendalo inokusetyenziswa njengomgangatho wokuchonga. I-HPMC inyibilikiswa kwiinyibiliki eziphilayo (ezinjenge-acetone, ethanol, njl.), Kodwa i-infline kwizinyithi ezinamafutha. Olu phawu lunokuqinisekiswa ngakumbi ngokuvavanya ukusolula kwayo kwiinyikima ezifanelekileyo.

I-3. I-infrared spectroscopy (ir) yokuchonga
I-infrared spectroscopy (ir) sisixhobo esichanekileyo sokuchonga esinokunceda ukuqinisekisa ubume bemolekyuli ye-HPMC. Eyona nto iphambili ye-HPMC kukufakwa kwamaqela anjenge-methyl (-C3) kunye ne-hydroxypropyl (-C2CH (oh). Ubukho bala maqela bunokuqinisekiswa ziincopho zokuthambisa ze-IR spectrum.

I-Piection Actions yokufunxa ye-HPMC's IR Spectrum ibandakanya:

I-2920 cm-1 (i-ch yolule)

I-1450 cm ye-CM-1 (CH egod)

I-1100-1200 cm-1 (i-coc yolula i-vibration)

I-3400 CM-1 (OH yolule i-vibration, ixabiso eliphezulu linokutshintsha ngenxa yobukho bamanzi)

Ngokuthelekisa i-IR ye-IR yesampulu ye-HPMC esemgangathweni, inokuthelekiswa nesampulu yesampulu engaziwayo yokuqinisekisa ukuba isazisi sesampulu.

4. Ukuchongwa kweekhemikhali
I-HPMC, njengeempawu ze-ether, zineempawu ezithile zokuphendula ikhemikhali kwaye zinokuchongwa zezi zinto zilandelayo zeekhemikhali.

(1) Ukuphendula phantsi kweemeko ze-acidic:
Dibanisa isixa esincinci se-HPMC emanzini, yongeza i-gilute hydrochloric acid, kunye nobushushu. Ukuba into ebonakalayo ivela kwisisombululo, oko kuthetha ukuba iqulethe i-HPMC. Le mpendulo inokuchongwa ngokuzinza kwezakhiwo ze-hydroxypropy kunye namaqela e-methyl phantsi kweemeko ze-acidic.

(2) Ukusabela phantsi kweemeko ze-Alkaline: i-HPMC inyibilikisa emanzini ukwenza isisombululo seColoidal. Akulula ukunyibilika phantsi kweemeko ze-alkaline (ezinje ngesisombululo seSodium hydroxide), enxulumene ne-hydrophicicity ye-hydrophicicity kunye ne-hydrogel. Ukuba isisombululo sisiphambuka okanye siphindwe kabini, kuthetha ukuba i-HPMC ikhona.

5. Ukuchongwa kwendlela yokundwendwela i-HPMC yinto enempawu ze-viscosity, ukuze ichongwe yi-viscofity yayo kwisisombululo esinamandla. Ngokubanzi, i-HPMC iya kwenza into ethile nge-vissosity ethile emva kokunyibilika emanzini, kwaye uVekyusi unyuka ngokunyuka kwesisindo sayo semolekyuli.

Ukwenzela ukulinganisa i-viscofity, ulwelo lwesisombululo se-HPMC lungalinganiswa ngokusebenzisa i-visment yokujikeleza okanye i-sube ye-gube yeglasi. Ngokutsho kobunzima be-phudmc kunye nokuxinana kwesisombululo, uVipyasity unokuqikelelwa. Ukuba i-viscosity yesampulu iphantsi kakhulu kuneso sesisombululo se-HPMC esiqhelekileyo, inokubonisa ukuba izithako zayo zingenanto okanye ubunzima bemolekyuli buphantsi.

I-6. Indawo yokunyibilika / yokuvavanya i-HPMC, njengeyona ndlela iphakamileyo yemolekyuli, ihlala ingenayo inqaku elicocekileyo, kodwa liya kubonisa ukuthambisa okanye ukubola ngexesha lokufudumeza. Xa i-HPMC ishushu, utshintsho lwalo kubushushu obahlukeneyo lunokubonwa. Ngokubanzi, i-HPMC iya kuqalisa ukubola nge-180-200 ℃, ukukhulula izinto eziguqukayo (ezinjengeenyikima zamanzi kunye nezisombululo zezinto eziphilayo). Utshintsho kwindawo yokuhombisa inokuqinisekisa ngakumbi ukuba isampulu icocekile i-HPMC.

I-7. Ukungasebenzi kunye nendlela ye-teagen
Isisombululo esenziwa emva kokuba i-HPMC iphosakele ngokubanzi i-tendon ephantsi. Uxinzelelo lomphezulu wesisombululo se-HPMC unokulinganiswa kusetyenziswa i-tensiommeter yomphezulu okanye indlela yedrip. Ukuba ihambelana noxinzelelo lomphezulu wesisombululo esisezantsi, oko kuthetha ukuba isampulu yi-HPMC.

Ezi zinto zingenisayo zilapha ngasentla nezilula zokuchonga i-hydroxlypropyl methylcelose (i-HPMC). Ezi ndlela zichonga i-HPMC kwii-angles ezininzi ezinje ngembonakalo, ukuphendula kweekhemikhali, i-viscosity, inqaku lesampulu linokuqinisekiswa ngempumelelo, ukubonelela ngesiqinisekiso kwisicelo sayo kumashishini ahlukeneyo.