Ukulungiswa kunye neepropathi ze-hydroxypropyl methylcelcelceluplose

Hydroxypropyl methylcelceluplose. Sisixhobo esifanelekileyo sokulungisa ukulungiselela iifilimu zokupakishwa kwamanzi ezinyibilikayo.

Ifilimu yokupakisha amanzi anyibilikayo luhlobo olutsha lwezinto eziluhlaza, ezifumene ingqalelo enkulu eYurophu naseMelika kunye namanye amazwe. Ayikhuselekanga kuphela kwaye ayisebenzi kakuhle ukuyisebenzisa, kodwa isombulula ingxaki yokupakisha inkunkuma. Okwangoku, iifilimu ezinyibilikayo zamanzi ikakhulu zisebenzisa izixhobo ezisekwe kwiPetroleum ezinjenge-polyvinyl utywala kunye ne-polythyethylene oxide njengezixhobo zohlaza. I-petroleum sisixhobo esingavuselelekiyo, kwaye ukusetyenziswa okukhulu kuya kubangela ukunqongophala kwezixhobo. Kukho neefilimu ezinyibilikayo zamanzi ezisebenzisa izinto zendalo ezinjengesitatshi kunye neprotein njengezinto eziluhlaza, kodwa ezi filimu zinyibilikayo zineempawu ezigwenxa zoomatshini. Kweli phepha, uhlobo olutsha lwefilimu yephakheji yamanzi ilungiselelwe isisombululo sendlela yokwakha ifilimu esebenzisa i-hydroxlypropyl methylcelose. Iziphumo zoxinzelelo lwe-HPMC yefilimu yefilimu kunye nefilimu yokwakha ifilimu kumandla e-thensile, i-Elonghation kwikhefu, ukuhambisa ukukhanya kweefilimu ze-HPMC zamanzi ze-HPMC zaxoxwa. I-Glycerol, i-sortolil kunye ne-glutaraldehde yayisetyenziselwa ukuphucula ukusebenza kwefilimu yepakethi ye-HPMC. Okokugqibela, ukuze kwandise ukusetyenziswa kwefilimu ye-HPMC ye-HPMC kwi-filimu yephakheji ye-HPMC kwiphakeji yokutya, i-biob yegqabi (i-AOB) yayisetyenziselwa ukuphucula iipropathi ze-Anti Iziphumo eziphambili zezi zilandelayo:

. Xa uxinzelelo lwe-HPMC yi-5% kwaye iqondo lobushushu lefilimu lingama-50 ° C, iipropathi ezibanzi zefilimu ye-HPMC zingcono. Ngeli xesha, amandla anobungqingili malunga ne-116MPA, i-elonglong kwikhefu imalunga ne-31%, ukuhambisa ukukhanya ngama-90%, kunye nexesha lokuchithwa kwamanzi yi-55min.

. Xa umxholo we-glycerol ungaphakathi kwe-0.05% kunye ne-0.25%, impembelelo yeyona ilungileyo, kunye ne-elonghation yeyona filimu ye-HPMC ifikelela malunga ne-50%; Xa umxholo we-Sorbiol yi-0.15%, i-elonghation kwikhefu yonyuka ukuya kwi-45% okanye njalo. Emva kwefilimu ye-HPMC ye-HPMC yaguqulwa nge-Glycerol ne-shorbil, amandla e-subile kunye neepropathi ze-phedrical banciphe, kodwa ukwehla akubanga lubalulekileyo.

. Xa ukongezwa kwe-glutaraldehde yayiyi-0.25%, iipropathi zoomatshini kunye neempawu ezibonakalayo zefilimu zafikelela kwi-Intanethi. Xa ukongezwa kwe-glutaraldehde yayingu-0.44%, ixesha lokutsala amanzi lafikelela kwi-135 min.

. Xa i-0.03% AOB yongezwa, ifilimu ye-AOB / i-AOB / i-HPMC yayinomgangatho wama-89% kwi-radicals yasimahla ye-DPHMC ngaphandle kwe-HPMC ngaphandle kwe-AOB ngaphandle kwe-AOB ngaphandle kwe-AOB ngaphandle kwe-AOB.

Amagama aphambili: ifilimu yephakheji enyibilikayo yamanzi; hydroxypropyl methylcelceluplose; iplastiki; iarhente yokudibanisa i-ackert; i-antioxidant.

Isiqulatho

ISISHWANKATHELO ............................................. ..........................................................................................................................................................................................................................

I-Abstsing the the .........................................................................................................................................................................................................................................................................................................................................

Isiqulatho…………………………………………. .................................................................................................................................................................................

ISAHLUKO SOKUQALA Intshayelelo .......................................... .....................................................................................................................................................

1.1Water-implet- ifilimu enyibilikayo ...

1.1.15Polyvinyl utywala (i-PVA) ifilimu enyibilikayo yamanzi .....................................................................

I-1.1.2Polyleneneethythylene (POU) ifilimu enyibilikayo ye-Wood-Able-Ater .............................................................

1.1.3Sturch-Ifilimu esekwe emanzini anyibilikisiweyo ...

1.1.4 Iifilimu ezinyibilikayo zamanzi ze-protein.

1.2 hydroxypropyl methylcelceluplose ................................................... .. ..................................................... 3

1.2.1 Ubume be-hydroxypropyl methylcelcelcelose .............................................................................................................................................

1.2.2 Ukuzithoba kwamanzi kwe-hydroxypropyl methylcelcelceluplose

1.2.3 Iipropathi zokwenza ifilimu ze-hydroxypropyl methylcelcelgalose ..................................................... .4

1.3 Ukulungiswa kweplastiki ye-hydroxypropyl methylcelcelgalose ifilimu ....................................................................... ..4

1.4 Ukuguqulwa ngokudibeneyo kwe-hydroxypropyl methylcelcelcelsese ifilimu ...

1.5 Iipropathi ze-antioxidimatives ze-hydroxypropyl methylcelcelcelsese ifilimu ................................ 5

1.6 Isicelo sesihloko .............................................................. .............................................

1.7 Umxholo woPhando .............................................................................................................................................................................

ISAHLUKO 2 UKULUNGISELELA NEPRORTUTSMPPOPLL ye-Ithyl Seleling Ifilimu yephakheji .................................................................................................................................................................................................................................................................

2.1 Intshayelelo ... 8

2.2 Uvavanyo lovavanyo .............................................................. .................................................

2.2.1 Izinto zovavanyo kunye nezixhobo .......................................................... ......... ..8

2.2.2 Ukulungiswa okuthile ....................................................................................................................................................................................................... ..9

2.2.3 Isimo kunye novavanyo lwentsebenzo ......................................... .. ............................................. .9

2.2.4 Ukulungiswa kwedatha ......................................... .............................................................................................................................................

2.3 Iziphumo kunye nengxoxo .............................................................................................................................................................................................................

2.3.1 Isiphumo sokwenza isisombululo sefilimu kwi-HPMC Fightms .................................. .. ..................................................................................................... ........................................ 10

2.3.2 Influence of film formation temperature on HPMC thin films ………………………………………… ……………………………………………………………………………………………………..13

2.4 ISISHWANKATHELO Isahluko ............................................................................................................................................................. ..

ISAHLUKO SESI-3 IINKQUBO ZE-PROCTISIZIS KWI-HPMC YOKUGQIBELA I-HPMC yeBholamu ye-HPMC ye-HPMC ...................................................................................17

3.1 Intshayelelo ...................................................................................................................................................................................................................................................................................

3.2 Uvavanyo lovavanyo ...

3.2.1 Izinto zovavanyo kunye nezixhobo .....................................................................................................

3.2.2 Ukulungiswa okuthile .........................................................................................

3.2.3 UMBONO NOKUVAVANYA KOKUVAVANYA ......................................... .. .....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................

3.2.4 Ukulungiswa kwedatha .......................................................... ................................................. ..19

3.3 Iziphumo kunye nengxoxo .....................................................................................................................

3.3.1 Iziphumo ze-glycerol kunye ne-shorbiol kwi-Insulfmer Spectrum ye-HPMC yeefilimu ...

3.3.2 Isiphumo se-glycerol kunye ne-shorbil kwiipateni ze-XRD zefilimu ye-HPMC ...

3.3.3 Iziphumo ze-glycerol kunye ne-shorbils kwiipropathi zoomatshini ze-HPMC Fightms .....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................

3.3.4 Iziphumo ze-glycerol kunye ne-shorbils kwipropathi ye-HPMC yeefilimu ze-HPMC .............................................................................................................................................................................................................................................

3.3.5 Impembelelo ye-glycerol kunye ne-sorbiol kwi-Somabing yamanzi yeefilimu ze-HPMC .......... 23

3.4 Isishwankathelo seSahluko .............................................................................................................................................................................

ISAHLUKO 4 IINKQUBO ZE-ARDS YOKUGQIBELA KWI-HPMC ye-HPMC ye-HPMC ye-HPMC ye-HPMC ye-HPMC ye-HPMO .................................................................................................................................................................................................................................................................................

4.1 Intshayelelo .............................................................................................................................................................................................................................................. 25

4.2 Uvavanyo lovavanyo .....................................................................................................................................................................................................................

4.2.1 Izinto zovavanyo kunye nezixhobo .........................................................................................

4.2.2 Ukulungiswa okuthile ..................................................................................................................................................................................... ..26

4.2.3 Isimo kunye novavanyo lwentsebenzo ......................................... .. ........ ....26

4.2.4 Ukulungiswa kwedatha ...................................................... ..................................................... ..26

4.3 Iziphumo kunye nengxoxo .........................................................................................................................................................................................

4.3.1 Infrared absorption spectrum of glutaraldehyde-crosslinked HPMC thin films……………………………………………………………………………………………………………………………………………..27

4.3.2 Iipateni ze-XRD ze-GLTHANAREAREHYDDER CODMC Fibles ...................................2..27

4.3.3 Isiphumo se-glutaraldehyde kwi-Somabing yamanzi yeefilimu ze-HPMC ......................... ..28

4.3.4 Isiphumo se-GLTHutaralEdde kwiipropathi zoomatshini weefilimu ze-HPMC ezinqabileyo ... 29

4.3.5 Isiphumo se-GLTHANAREARDODDDDE KWIPROPAIC ZE-OPPMC Fightms ......................... 29

4.4 ISISHWANKATHELO Isahluko .........................................................................................................................

ISAHLUKO 5 I-ANPMXMCDIDAD YEMPIL YOKUGQIBELA YAMANZI AMANQAKU E-HPMC -C ................................. ..31

5.1 Intshayelelo .................................................................................................................................................................................................................................................................

5.2 Uvavanyo lovavanyo .............................................................................................................................................................................................................................................

5.2.1 Izinto zovavanyo kunye nezixhobo zovavanyo .............................................................

5.2.2 Ukulungiswa okutsha .................................................................................................................................................................................................................................

5.2.3 UMBONO NOKUVAVANYA NGOKUGQIBELA ......................................... .. .................................................

5.2.4 Ukulungiswa kwedatha .......................................................... ......................................................... 33

5.3 Iziphumo kunye noHlatho .............................................................................................................................................................................

5.3.1 Uhlalutyo lwe-FT-Ir ...

5.3.2 I-XRD uhlalutyo .............................................................................................................................................................................

5.3.3 Iipropathi ze-antioxidant ...

5.3.4 Solubay Water .........................................................................................................................................................................................

5.3.5 Iipropathi zoomatshini .........................................................................................................................................................................................

5.3.6 Ukusebenza okukhethiweyo ...

5.4 Isishwankathelo seSahluko .................................................................................................................................................................

ISAHLUKO 6 ISIQINISEKISO ...................................................... ..................................................................... ..39

Izalathiso .............................................................................................................................................................................................

Iziphumo zophando ngexesha lesiVekisi .................................................................................................................................

IMIQATHANGO YOKUGQIBELA

ISAHLUKO SOKUQALA Intshayelelo

Njengezinto eziluhlaza ezinenoveli, ifilimu yokupakisha amanzi anyibilikayo isetyenziswe ngokubanzi ekupakisheni iimveliso zakwamanye amazwe (njenge-United States, iJapan, iFrance, njl njl)) [1]. Ifilimu enyibilikayo yamanzi, njengoko igama lithetha, yifilimu yeplastiki enokuthi ichithwe emanzini. Yenziwe ngezinto ezinyibilikayo zamanzi ezinokunyibilika emanzini kwaye zilungiselelwe yinkqubo yokwenza ifilimu ezithile. Ngenxa yepropathi yayo ekhethekileyo, ilungele kakhulu abantu ukuba bapakishe. Ke ngoko, abaphandi abangakumbi sele beqalisile ukunikela ingqalelo kwiimfuno zokukhuselwa kwendalo kunye nokulula [2].

1.1 Ifilimu enyibilikayo yamanzi

Okwangoku, iifilimu ezinyibilikayo zamanzi ikakhulu ziifilimu ezinyibilikayo zisebenzisa izixhobo ezisekwe kwi-perlyvinkl kunye ne-polybethylene oxide njengezixhobo zendalo, kunye neproteyini njengezixhobo zohlaza.

1.1.1 Polyvinyl utywala (PVA) ifilimu enyibilikayo yamanzi

Okwangoku, ezona filimu zisebenzisa amanzi anyibilikayo kakhulu emhlabeni ziyiifilimu ze-PVA ezinyibilikayo. I-PVA yi-vinyl polymer enokusetyenziswa yintsholongwane njengomthombo wekhabhoni kunye nomthombo wamandla, kwaye inokugqitywa phantsi kwento ye-bitteria kunye ne-enzymes yexabiso eliphantsi, ukuchasana kweoyile ebalaseleyo, kunye ne-4]. Ifilimu ye-PVA ineepropathi ezintle zoomatshini, ukuzivumela okuqinileyo kunye nokukhusela kakuhle kwendalo esingqongileyo. Isetyenziswe ngokubanzi kwaye inomgangatho ophezulu wentengiso. Yeyona nto isetyenziswa kakhulu kwaye yeyona filimu iphambili yephakheji yamanzi kwintengiso [5]. I-PVA ineentlonelo ezilungileyo kwaye inokuthi ibolekwe ziintsholongwane ukuvelisa i-CO2 kunye ne-H2O emhlabeni [6]. Uninzi lophando kwiifilimu ezinyibilikayo zamanzi ngoku kukuguqula kunye nokuzidibanisa ukuze ufumane iifilimu ezinyibilikayo zamanzi. UZhao Linlin, Xiong Hanguo [7] wafunda ukulungiswa kwefilimu yephakheji enyibilikayo kunye ne-PDA njengeyona nto iphambili ye-orthogonal, kwaye i-oxids i-20%, i-gellium ye-16% ye-4%. Emva komile ifilimu efunyenweyo, ixesha elinyibilikayo lamanzi emanzini kubushushu begumbi yi-101s.

Ukugweba kule meko yangoku yophando, ifilimu ye-PVI isetyenziswe ngokubanzi, indleko ephantsi, kwaye ilungele izinto ezahlukeneyo. Yeyona nto ifanelekileyo yokupakisha amanzi anyibilikisiweyo okwangoku. Nangona kunjalo, njengezinto ezisekwe kwiPetroleum, i-PVA sisixhobo esingavuselelekiyo, kwaye inkqubo yayo yokuvelisa izilwanyana ingangcoliswa. Nangona i-United States, iJapan nakwamanye amazwe idwelise njengento engeyiyo enetyhefu, ukhuseleko lwayo lusavulelekile kumbuzo. Zombini ukuphefumla kunye nokungenisa kuyingozi emzimbeni [8], kwaye ayinakubizwa ngokuba yi-chemistry epheleleyo.

1.1.2 Poalyethylene oxide (PO) ifilimu enyibilikayo yamanzi

I-Polythylene oxide, ebizwa ngokuba yiPolythyylene oxide, yi-thermoplastic, i-thermoplastic, i-polymer enyibilikayo enokudityaniswa namanzi kuwo nawuphi na umlinganiselo wobushushu begumbi [9]. Ifomula yesakhiwo yePolythylene Oxide yi-H - (- i-OCH2C2-) N-OH, kunye nesininzi sayo semolekyuli siya kuchaphazela ubume bayo. Xa ubunzima bemolekyuli bukuluhlu lwama-200 ~ ~ 20000, kubizwa ngokuba yiPolythylene Glythlic (i-Peg), kunye nobunzima bemolekyuzi bungabizwa ngokuba yiPolyethylene oxide (POO) [10]. Peo ngumgubo omhlophe ohambayo, ekulula ukuqhubekeka nokwakha. Iifilimu ze-POO zihlala zilungiselelwe ngokudibanisa iiplastiki, ukuzinza kunye neefilitha kwizinto zokugcina i-thermoplaestic [11].

Ifilimu kaPeo yifilimu enyibilikayo yamanzi enomhlaba ofanelekileyo owomeleza amanzi okwangoku, kwaye uninzi lweepropathi zendlela zilungile, kodwa iimeko ezinoluvo, kunye nefuthe elithile lokusingqongileyo, kwaye uninzi lwemisebenzi yayo isetyenziswa. Ifilimu ye-PVA [12]. Ukongeza, abantu bakwanetyhefu ethile, ngoko kunqabile ukuba kusetyenziswe kwiphakheji yemveliso [13].

1.1.3 Ifilimu esekwe kumanzi anyibilikayo

Isitatshi sisimo sendalo esiphakamileyo semolekyuli, kwaye iimolekyuli zayo zinenombolo enkulu yamaqela e-hydroxyl, ke kukho intsebenzo eqinileyo phakathi kweemolekyuli, ukuze isitatshi sinzima ukunyibilika, kwaye kunzima ukunxibelelana nezinye iipolymers. Iqhubekeke kunye [14,15]. Ukuswela amanzi isitatshi kuhlwempuzekile, kwaye kuthatha ixesha elide ukungcungcutheka emanzini abandayo, isitatshi esiguquliweyo, oko kukuthi, isitatshi esinyibilikayo, sihlala sisebenzisa iifilimu ezinyibilikayo. Ngokubanzi, isitatshi siguqulwe ngeendlela ezenziwa ngamachiza njengokuncamisa, i-ether, ukulungisa i-stambisa yokutshintsha isakhiwo ses stababing [7,16].

Yazisa i-Ether Binds kumaqela eetarnar ngeikhemikhali okanye isebenzise i-oxes eqinileyo yokutshabalalisa ubume bemveli yemvelo yokufumana isitatshi esiguquliweyo sifumana isitatshi esiguquliweyo sefilimu. Nangona kunjalo, kubushushu obuphantsi, ifilimu yesitatshi ineepropathi ezingafezekanga kakhulu kunye nokungafihli nto ingekho mthethweni, ngoko kwiimeko ezininzi, kufuneka zilungiselelwe ngokudibanisa nezinye izinto ezifana ne-PVA, kwaye ixabiso lokufumana ixabiso aliphezulu.

1.1.4 I-protein esekwe emanzini

Iprotein yinto ye-ficromolecular yendalo equkethwe kwizilwanyana nakwizityalo. Kuba izinto ezininzi zeproteyini azinambulelo emanzini kubushushu begumbi, kunyanzelekile ukuba kusombulule ukubethwa kwempahla emanzini emanzini egumbini lokulungisa iifilimu zamanzi kunye nezixhobo. Ukwenzela ukuphucula ukwahlulwa kwezinto zeproteni, kufuneka zilungiswe. Iindlela eziqhelekileyo zokulungiswa kwehemicali zekhemikhali ziquka ukunganyaniseki, i-phthaloamididation, iphoskhory, njl. [18]; Isiphumo sokutshintsha kukutshintsha ubume be-protein, ngaloo ndlela kunyuke ukugcwaliswa, ukungqubana, ukusebenza njengokuqulunqwa kwamanzi kunye nokuzinza kuhlangabezana neemfuno zemveliso kunye nokusebenza. Iifilimu ezinyibilikayo zamanzi ezinyibilikayo zinokuveliswa ngokusebenzisa imveliso yezolimo nezolimo ezifana nokubekwa kwezinto eziluhlaza, okanye ngokuvelisa izinto zepetroli, kwaye zinefuthe elincinci kwindalo esingqongileyo [19]. Nangona kunjalo, iifilimu ezinyibilikayo zamanzi zilungiselelwe yiProtein efanayo njengoko i-matrix ineepropathi ezigwenxa kunye nokuzahlula kwamanzi asezantsi kubushushu obuphantsi okanye ubushushu begumbi, ngoko uluhlu lwabo lokusebenzisa lube mxinwa.

Ukuzama ukuphakama, kubaluleke kakhulu ukuphuhlisa umxholo omtsha, ovuselelekileyo, amanzi acociweyo, amanzi ngengozi yokuphucula ukusilela kwiifilimu ezinyibilikayo zamanzi.

I-HydroxyPOpyl methyl seluplopy (Hydroxypropyl Methyl Selelose, i-HPMC ye-Polymer) yi-polymer yendalo, engenabungozi, ingenabuchule, kwaye ingakhuphisani nabantu abanokuphinda bafumaneke, kwaye abuphindise ubuncwane obukhulu kwindalo [20]]. Inomhlaba olungileyo wokuzola kwamanzi kunye neempawu zokwenza ifilimu, kwaye unemiqathango yokulungiselela iifilimu zokupakisha ezinyibilikayo zamanzi.

1.2 hydroxypropyl methylcelceluplose

I-Hydroxypropyl Methyl Selelise I-suplowese yamanzi anyibilikayo [21]. I-HydroxyPOpyl Methylcelcelose inezi mpawu zilandelayo:

(1) Imithombo eninzi nehlaziyiweyo. Izinto eziluhlaza ze-hydroxypropyl methylcelgalose yeyona nto ininzi yendalo emhlabeni, ekwazixhobo ezihlaziyiweyo.

(2) Indalo inobuhlobo kunye ne-biodegraded. I-HydroxyPOpyl Methylcelcelgalose ayinatyhefu kwaye ayinabungozi emzimbeni womntu kwaye inokusetyenziswa kumashishini kunye namashishini okutya.

(3) Uluhlu olubanzi lokusebenzisa. Njengezinto ezinyibilikayo zamanzi, i-Hydroxypropyl Methylcelcelgalose inamanzi amnandi, ukugxothwa, ukutya kwefilimu, kunye nemichiza yemimandla [21].

1.2.1 Ulwakhiwo lweHydroxypropyl Methylcelcelce

I-HPMC ifunyenwe kwi-seluplose yendalo emva kokuqiniseka, kunye nenxalenye ye-Polyhydropyl ye-Ether kunye ne-methyl ikhutshiwe nge-propylene oxide kunye ne-methyl chloride. I-HPMMC ye-HPMC ye-HPMC ye-HPMCS METYL isuka kwi-1.0 ukuya kwi-2.0, kunye ne-hydroxyPropy ye-Deageages iphakathi kwe-0.1 ukuya kwi-1.0. Ifomula yayo yemolekyuli iboniswe kumzobo 1.1 [22]

Ngenxa ye-hydrogen eyomeleleyo ye-hydrogen phakathi kwe-selluloese yendalo, kunzima ukunyibilikisa emanzini. Ukunyibilika kwe-cutulose emanzini kuyaphucuka kakhulu kuba amaqela e-ether aziswa kwi-cutyuliese ye-othersiese, etshabalalisa i-hydrogen ye-hydrogen phakathi kweemolekyuli eziphakathi kwamanzi [23]]. I-Hydroxypropyl Methylcelcellulose (HPMC) yi-hydroxassylkyl alkyl aly [21], icandelo layo le-D-GLucopyl) kunye ne-HydroxyProOpy (-ch- (intsebenzo ye-sell ixutywe I-Ethen yinto ebonakalayo ebanzi yolungelelwaniso kunye negalelo leqela ngalinye. - [I-OCH2CH (Ch3)] IQela le-Hydroxyl ekupheleni kweqela le-NH yeqela liqela elisebenzayo, elinokuphinda libe nefuthe lokungaphezulu, kwaye elinemiphumo yokufaka iplastiki yangaphakathi; -Och3 liqela elikufutshane, indawo yokuphendula iya kwenziwa ingasebenzi emva kokufaka endaweni yabelwe [21]. Amaqela e-hydroxyl kwi-chain yesebe elisandula ukongezwa kunye namaqela e-hydroxyl oshiyekileyo anokuguqulwa ngala maqela angasentla, ekhokelela kwizakhiwo ezinzima kunye neepropathi ezinokusetyenziswa ngaphakathi kwenqanaba elithile lamandla [40].

1.2.2 Ukuzithoba kwamanzi kwi-hydroxypropyl methylcelcelceluplose

I-Hydroxypropyl Methylcelcelcelose inezinto ezininzi ezibalaseleyo ngenxa yesakhiwo sayo esikhethekileyo, eyona iphawuleka kakhulu kuyo i-isotololity yawo amanzi. I-slow i-colloidal isisombululo kumanzi abandayo, kwaye isisombululo sinomsebenzi othile womphezulu, ukungafihli nto iphakamileyo kunye nokusebenza ngokuzinzileyo [21]. I-HydroxyPOpyl Methylcelcelcelse yeyher ifunyenwe emva kokuba i-methylcelculose iguqulwe yi-propylceliod kunye ne-shoolbone yomhlaba onesifo se-propylcelulose efana ne-methylceluptalo [21], kwaye amanzi ayo emanzini aphuculwe. I-Methyl Selelose kufuneka ibekwe kwi-0 ukuya kwi-5 ° C kangangemizuzu engama-20 ukuya kwengama-40 ukufumana isisombululo semveliso ngokwenza izinto ezibonakalayo kunye nohlobo oluzinzileyo [25]. Isisombululo se-hydroxypropyl methylcelcelgalose imveliso kufuneka ibe kwi-20-25 ° C yokufezekisa uzinzo kunye nokungafihli okucacileyo [25]. Umzekelo, i-rover-idropypropyl methylcelcelsulose (i-Granular I-0.2-0.5 mm) inokuchithwa ngokulula emanzini amaqondo amane e-4% ifikelela kuma-20 ° C.

1.2.3 Iiprogram zokwenza ifilimu ze-hydroxypropyl methylcelcelceluplose

I-Hydroxypropyl Methylcelcelse Stolsose ineepropathi ezibalaseleyo zefilimu, ezinokubonelela ngeemeko ezilungileyo zokudibana kwamayeza kachiza. Ifilimu ethandekayo eyenziwe yiyo ayinantsingiselo, engenantsingiselo, inzima kwaye ibonakale [21].

I-YAn Yonzhong [26] Usebenzise uvavanyo lwe-orthogonal ukuphanda iipropathi zokwenza ifilimu ye-hydroxypropyl methylceluplose. Ukuhlolwa kwenziwa kumanqanaba amathathu ngeendlela ezahlukeneyo kunye nezinyibilikisiweyo ezahlukeneyo njengezinto. Iziphumo zibonise ukuba ukongeza i-10% ye-hydroxylpyl methylcelcelceluplose i-50% ye-Ethanol ineempawu zokwenza ifilimu, kwaye inokusetyenziswa njengento yokwenza ifilimu yefilimu.

1.1 Ukuguqulwa kweplastiki ye-hydroxypropyl methylcelcelcelse

Njengesixhobo esihlaziyiweyo sendalo, ifilimu ilungiselelwe ukusuka kwisellose njengesizinzo esifanelekileyo kunye nokuziqhelanisa, kwaye i-biodegraddIbradradradrady emva kokuba ilahlwe, ayinabungozi kwindalo esingqongileyo. Nangona kunjalo, iifilimu ezingafakwanga zeselselose zinezinto ezimbi, kwaye isellulose zinokuba ziplastiki kwaye zilungisiwe.

. Iziphumo zibonise ukuba i-Elongngetion yekhefu kwifilimu ye-Seletate inyuke nge-36% kwaye i-50% xa iqhezu le-triethyl kunye ne-acety tetrafy yayiyi-10%.

Luo Qiudui et al [28] Fundenisa imiphumo ye-Glycerol, i-steric acid kunye neglucose kwiipropathi zoomatshini be-methylcelsulose membrase. Iziphumo zibonise ukuba inqanaba le-i-methyl seluplose ibingcono xa umxholo we-glycelose wayengcono kwi-methyl ye-Glucose kwaye i-Stearic Acid yayiyi-0.5%.

I-Glycerol yinto engenamibala, imnandi, icacile, i-vicous i-viscous enencasa emnandi efudumeleyo, ehlala yaziwa njenge-glyrin. Ilungele uhlalutyo lwezisombululo ezikhutshelweyo, izithombe, iiplastiki, njl njl. I-Sorbibil, i-hygroscopic ye-hygroscopic powder okanye i-crystalline powder, iiflethi okanye iigrams, ngaphandle. Inemisebenzi yokufana nokuthantamisa kunye nokugcinwa kwamanzi. Ukongeza kancinci kwimveliso yokuhlafuna itshungama kwaye ipipi inokugcina ukutya ithambile, iphucule umbutho kwaye inciphise ilukhuni kwaye idlale indima yesanti. I-Glycerol kunye ne-sorbil zimbini izinto ezinyibilikayo, ezinokuxubelwa ziiselwase ezinyibilikayo zamanzi. Banokusetyenziswa njengabaphangisi kwi-seluplose. Emva kongeziweyo, banokuphucula ukuguquguquka kunye ne-elongiya kwikhefu lefilimu yeSeluplose. [29]. Ngokubanzi, uxinzelelo lwesisombululo yi-2-5%, kwaye isixa seplastiki siyi-10 ukuya kwi-20% ye-seluplose ether. Ukuba umxholo weplastiki uphezulu kakhulu, i-shrinkagety ye-shrinknon ye-colloid yokuphelelwa ngumzimba iya kwenzeka kubushushu [30].

1.2 Ukuqhutywa kwentembeko ye-hydroxypropyl methylcelcelsese ifilimu

Ifilimu enyibilikiswe amanzi anyibilikisileyo, kodwa akulindelekanga ukuba inyibilike ngokukhawuleza xa isetyenziswa ngamanye amaxesha, ezinjengeengxowa zokupakisha imbewu. Imbewu inxibe ifilimu enyibilikayo yamanzi, enokunyusa umgangatho wokusinda kwembewu. Ngeli xesha, ukwenzela ukukhusela imbewu, akulindelanga ukuba ifilimu iya kunyibilika ngokukhawuleza, kodwa ifilimu kufuneka kuqala idlale isiphumo esithile sokugcina amanzi kwimbewu. Ke ngoko, kuyimfuneko ukuba wazise ixesha elinamanzi lefilimu. [21].

Isizathu sokuba i-Hydropyl Gothylcelcelsulose inolwazi oluhle lwamanzi kukuba kukho inani elikhulu lamaqela e-hidroxyl kwi-aldehyplyDropyl methylcelic amaqela e-hydroxilic I-HydroxyPOpyl Methylcelcelgalose incitshisiwe, ngaloo ndlela kuncitshiswa ukungathobeli kwamanzi kwifilimu ye-hydropylcel ye-hydylcelose ifilimu kunye ne-AldeHYSE ivelisa iimpawu ezininzi zefimilizeni. I-Aldehydeds idibene ne-hydroxypropyl methylcelcelose ibandakanya i-glutaralde, i-GYOXALDE, kwaye i-Golutaltehyde inamaqela amabini aselundweni. Ikhuselekile, ke i-glutaraldehyde isetyenziswa rhoqo njenge-arhente yokunxibelelanisa i-wist ye-Eoni. Isixa solu hlobo lwe-arhente yokudibanisa i-contred-contrity kwisisombululo yi-7 ukuya kwi-10% yobunzima be-ether. Iqondo lobushushu lonyango limalunga ne-0 ukuya kwi-30 ° C, kwaye ixesha yi-1 ~ 200 imizuzu [31]. Ukunxibelelanisa ukuphendula okugqogqa kudinga ukwenziwa phantsi kweemeko ze-acidic. Okokuqala, i-acid ye-Acid eyomeleleyo okanye i-orboxylic acid yongezwa kwisisombululo sokulungelelanisa i-PH yesisombululo ukuya kwi-4-6, kwaye emva koko kwenziwa ama-Aldenes ukuba aqhubekeke [32]. I-AIDDS isetyenziselwa kubandakanya i-HCL, H2SO4, i-acetic acid, i-cicric acid, kwaye inje. I-acid kunye ne-Aldehyde nazo zongezwa ngaxeshanye ukwenza isisombululo siphumeze ukunxibelelanisa ukunxibelelanisa kwi-HH ye-hle (33].

1.3 Iipropathi ze-antiophawudiatives ze-hydroxypropyl methylcelcelcelse films

I-Hydroxypropyl Methylcelcelcelose ityebile kwizixhobo, kulula ukwenza ifilimu, kwaye inefuthe elitsha lokuhlala. Njengokutya okulondolozekileyo, inamandla amakhulu okuba ngamandla [34-36].

Zhuang rongyu [37] Usebenzise i-hydroxypropyl methylcelcelsulose (HPMC) yefilimu, wayicenga kwi-Tomato, emva koko wayigcina nge-20 ° C kangangesifo seTomatisi kunye nombala. Iziphumo zibonisa ukuba ubunzima be-Tomato nge-HPMC Deating iphezulu kunelo ngaphandle kokuthuthuza. Kwangqinelwa ukuba ifilimu ye-HPMC inokulibazisa ukutshintsha kombala weetamato ezivela kwipinki ukuba ibomvu xa igcinwe kwi-20 ℃.

[38] Ufunde iziphumo ze-hydroxypropyl methylcelculose (i-HPMC) Ukuhamba ngonyango, i-anthocchanin synthesis kunye nomsebenzi we-antiyorknin kunye nomsebenzi we-antioxridant we "WUZHHEY" Iziphumo zibonise ukuba intsebenzo ye-anti-oxidation ye-Bayberry ephathwe ngefilimu ye-HPMC yaphuculwa, kwaye ireyithi yokuboleka ngexesha lokugcina inciphile, kwaye ifilimu ye-5% ye-HPMC yayiyeyona nto ilungileyo.

Wang kaikai et al. [39] Usebenzise "i-Wozhong" isiqhamo seBayberry njengoko iziqhamo zovavanyo zokufunda ifuthe le-riboflavin-i-ranchylcelcel methylcelose (i-HPMC) ye-Antioxrceriest yeziqhamo kwi-1 ℃. Iziphumo zomsebenzi. Iziphumo zibonise ukuba iziqhamo ze-riboflavin ze-HPMC ze-HPMC isebenza ngakumbi kune-riboflavin enye okanye i-HPMC, i-HPMC, inciphise ireyithi yexabiso le-bayberry ngexesha lokugcina iziqhamo.

Kwiminyaka yakutshanje, abantu baneemfuno eziphezulu neziphezulu zokhuseleko lokutya. Abaphandi basekhaya nakwamanye amazwe baye bashenxisa ukugxila kwabo kophando kwizimvo zokutya zokupakisha izixhobo. Ngokongeza okanye ukutshiza i-antioxididants kwizinto zokupakisha, zinokunciphisa i-oxidation yokutya. Iziphumo zokubola [40]. I-Antiophawunts yendalo iye yachaphazeleka kakhulu ngenxa yokhuseleko lwabo oluphezulu kunye nemiphumo emihle yezempilo emzimbeni womntu [40,41].

I-Antiyoxidant yamagqabi e-bamboo (i-aob ye-AOB i-antioxidant yendalo enamavumba etyhefu ekhethekileyo ye-bamboo kunye ne-smoubioling elungileyo. Idweliswe kwi-GB2760 kazwelonke i-GB2760 kwaye ivunyiwe yinkonzo yempilo njenge-antioiyoxidant yokutya kwendalo. Ingasetyenziselwa njengesongezo sokutya kwiimveliso zenyama, iimveliso zasemanzini kunye nokutya okukhukhumeleyo [42].

Ilanga lina njl njl. [42] Iphonononge izinto eziphambili kunye neepropathi ze-Antioisoogi ye-Antisooge kwaye zazisa ukusetyenziswa kwe-antioogo yegqabi le-bamboo ekutyeni. Ukongeza i-0.03% aob kwi-mayonnaise entsha, impembelelo ye-antioxidant yeyona icacileyo ngeli xesha. Xa kuthelekiswa nenani elilinganayo le-tiolyphenol, isiphumo sayo esingaphezulu silunge ngakumbi kuneyona polyfanos; Ukongeza i-150% ukuya kwi-MG / L, iipropathi ze-antioxidant kunye nokugcinwa kokugcinwa kwebhiya kuyanda kakhulu, kwaye ibhiya ihambelana ngokuchanekileyo nomzimba we wayini. Ngelixa kuqinisekisa umgangatho wokuqala we-Winer, ikwandisa ivumba kunye nencasa ye-biboo yamagqabi [43].

Isishwankathelo, i-Hydroxypropyl Methylcelcelcelose ineempawu ezintle zefilimu kunye nokusebenza kakuhle. Ikwayinto eluhlaza kunye neyonakalisayo, enokusetyenziswa njengefilimu yokupakisha kwicandelo lokupakisha [44-48]. I-Glycerol kunye ne-sorbiol zimbini iiplastiki zamanzi. Ukongeza i-glycerol okanye i-sorebil kwisisombululo sokwenza ifilimu sefilimu enokuphucula ubunzima befilimu ye-hydropylcelsele, ngaloo ndlela kunyusa ifilimu [49-51]. I-GlutaraldehdeDde isetyenziselwa intsholongwane esetyenziswayo. Xa kuthelekiswa nezinye i-AldeHYEYESE, ikhuselekile, kwaye ineqela le-dialdehyde kwimolekyuli, kwaye isantya sokudibanisa isiseko sizingisa ngokukhawuleza. Ingasetyenziselwa ukuqulunqwa kokunxibelelanisa ngokudibeneyo kwe-hydroxypropy methylcelcelcelsem. Inokuhlengahlengisa ukubenzela amanzi kwifilimu, ukuze ifilimu ingasetyenziswa ngamaxesha amaninzi [52-55]. Ukongeza i-Antioisoxidas ye-Antioisoo kwi-Hydroxypropyl MethylcelceLifit ye-Antioxidase ukuphucula iipropathi ze-antioxidant ye-Antioxidant yefilimu ye-Hydylcelose ifilimu kwaye yandise isicelo sokufaka ukutya.

1.4 Isiphakamiso sesihloko

Ukusuka kwimeko yophando yangoku, iifilimu ezinyibilikayo zamanzi zenziwe ikakhulu yi-PVA FILMS, iifilimu ze-pes, isekwe kumanzi anyibilikayo kunye neefilimu zamanzi. Njengesixhobo esekwe kwiPetroleum, i-PVA kunye neemveliso ezingekho mthethweni, kwaye inkqubo yemveliso yezixhobo zazo eziluhlaza zinokungcoliswa. Nangona i-United States, iJapan nakwamanye amazwe idwelise njengento engeyiyo enetyhefu, ukhuseleko lwayo lusavulelekile kumbuzo. Zombini ukuphefumla kunye nokungenisa kuyingozi emzimbeni [8], kwaye ayinakubizwa ngokuba yi-chemistry epheleleyo. Inkqubo yemveliso yezitatshi kunye ne-protein engenamanzi ayinabungozi kwaye imveliso ikhuselekile, kodwa zinokungancedi kakuhle kwefilimu, i-elongwation ephantsi, kunye nokwahlulwa ngokulula. Ke ngoko, kwiimeko ezininzi, kufuneka balungiswe ngokudibanisa nezinye izinto ezinjengePBA. Ixabiso lokusetyenziswa aliphezulu. Ke ngoko, oko kubaluleke kakhulu ukuphuhlisa i-pic entsha ebonakalayo yepilisi yefilimu ngentsebenzo egqwesileyo ukuphucula isiphene sefilimu enyibilikiswe amanzi.

I-HydroxyPOpyl Methylcelcelgalose i-polymer yendalo, engapheliyo kuphela kwezixhobo, kodwa iphinde isebenze. Inomhlaba olungileyo wokuzola kwamanzi kunye neempawu zokwenza ifilimu, kwaye unemiqathango yokulungiselela iifilimu zokupakisha ezinyibilikayo zamanzi. Ke ngoko, eli phepha licebisa ukulungiselela uhlobo olutsha lwefilimu yephakheji ye-WHDROXYPLLL Methylcelcel ), iarhente yokudibanisa i-ross-ross Ifilimu ye-methylcelcelgalose ifilimu yephakheji ye-Iswing ibaluleke kakhulu kwisicelo sayo njengephakethe elinyibilikisi lamanzi.

1.5 Umxholo woPhando

Iziqulatho zophando zezi zilandelayo:

1) Ifilimu yephakheji ye-HPMC yalungiswa ngesisombululo sendlela yokwakha ifilimu, kwaye iipropathi zefilimu zahlaziywa ukuba zifunde ifuthe lokwenza ifilimu yefilimu yefilimu ye-HPMC ye-HPMC.

2) Ukufundisisa iziphumo ze-glycerol kunye ne-sorbibil kwiipropathi zoomatshini, ukuzola kwamanzi kunye neepropathi ze-HPMC zeefilimu zokupakishwa kwamanzi ze-HPMC zamanzi.

3) Ukufundisisa ifuthe le-GLTHANAREARECHEHHYHDE ye-Arhente yokuLungelelanisa amanzi, iipropathi zoomatshini kunye neempawu ezibonakalayo zeefilimu zokupakishwa kwamanzi ze-HPMC zamanzi.

4) Ukulungiswa kwe-AOB / HPMC yefilimu yephakheji yepakethi. Ukuchasana kwe-oxidation, ukuzola amanzi, iipropathi zoomatshini kunye neempawu ezibonakalayo ze-AOB / ze-HPMC Iifilimu ezixineneyo zafundwa.

ISAHLUKO 2 UKULUNGISELELA NEPRORTUTS ye-HYDROXYPLL ye-Methyl Seleling yeFowuni

2.1 Intshayelelo

I-HydroxyPOpyl Methylcelcelcelose yindawo ye-seluplose yendalo. Ayisiyo inetyhefu, engacocekanga, izinzile ezihlaziyiweyo, kwaye inesitayile esihle samanzi kunye neempawu zokwenza ifilimu. Yindawo enamanzi epilisi yefilimu.

Esi sahluko siza kusebenzisa i-hydroxypropyl methylceluplose njengezixhobo zefilimu ze-2% ukuya kwi-6% yefilimu yefilimu, kwaye isebenzise i-filting yefayili yefilimu yefilimu, ifilimu, kunye nepropathi yoomatshini befilimu. Iipropathi zekristali zefilimu zibonakaliswa ngumlo we-X-ray, kunye namandla obuzini, i-elongretation ekhefu, i-haze ye-haze ye-Hydroxlcel ye-Mydylcelose ihlalutye kunye novavanyo lwamanzi kunye nokuluka kwamanzi.

2.2 ISebe lovavanyo

2.2.1 Izinto zovavanyo kunye nezixhobo

2.2.2 Ukulungiswa okutsha

I-1) Ukulinganisa: Ubunzima kwinani elithile le-hydroxypropyl methylcelcelceluplose ene-elektroniki.

2) Ukuchithwa: Yongeza i-Hydroxypropyl Methylceluplose ukuya kumanzi alungiselelwe amanzi alungiselelwe, uvuseleleke kubushushu obuqhelekileyo kunye nengcinezelo ide ichithwe ngokupheleleyo (i-DeFof) ukufumana uxinzelelo oluthile lokwakhiwa. Ulwelo lwe-membrane. Ifonyiwe nge-2%, i-3%, i-4%, 5% ne-6%.

I-3) Ukuqulunqwa kwefilimu: Ifilimu ye-hydroxypropyl methylcelcelgalose ifilimu yephakheji ye-25-50 μm ilungisiwe, kwaye ifilimu igqityiwe kwaye ibekwe kwibhokisi eyomisayo yokusetyenziswa. Ifilimu encinci yefilimu yefilimu (amaqondo obushushu ngexesha lokwenza ifilimu yefilimu kunye nefilimu yefilimu kunye nefilimu eyahlukileyo kwi-oveni eyomileyo yomoya. Ifilimu ye-hydroxylcelcel methylcelcelgalose ifilimu yephakheji ye-iswin eqingqiweyo malunga ne-45 μm ilungisiwe, kwaye ifilimu yabekwa kwaye ibekwe kwibhokisi eyomisayo ukuze isetyenziswe. Ifilimu elungiselelwe i-hydroxylcelcel methylcelcelgalose ifilimu yephakheji ye-inyibilikiswa idluliselwa kwifilimu ye-HPMC yefutshane.

2.2.3 Uphawu kunye neMilinganiselo yokuSebenza

2.2.3.1 I-Angle-Angle-Ray-Ray Ads

I-Angle-Angle-ray ye-X-ray (i-XRD) ihlalutya imeko ye-crystalline yesixhobo kwinqanaba lemolekyuli. I-X-ray ye-X-ray disccracpreter ye-ARL / Uhlobo lweNkampani ye-thermo ARMO kwi-Switzerland yayisetyenziselwa isigqibo. Imilinganiselo yokulinganisa: Umthombo we-X-Ray yayingumgca we-Nickel-Kcy bill (40KV, 40MA). I-angle yeskena ivela kwi-0 ° ukuya kwi-80 ° (2θ). Isantya sokuskena i-6 ° / imiz.

2.2.3.2 Iipropathi zoomatshini

Amandla obuzinile kunye ne-Elongition kwikhefu lefilimu zisetyenziswa njengemilinganiselo yokugweba iipropathi zayo, kunye namandla e-thenser (amandla efilimu) zibhekisa kuxinzelelo lweplastiki, kwaye iyunithi i-MPA. I-Elongiya kwikhefu (ukwaphula i-Elonglotion) ibhekisa kumyinge we-Elonglong xa ifilimu yaphukile kubude bokuqala, eboniswe kwi%. Sebenzisa i-Intern (5943) yohlobo lwe-Maninic Unitch ye-Intanethi ye-Inron (i-Shanghai), ngokweemeko ze-GB13022-92 yeesampulu zokuvavanya ubungqingqwa kunye nokucoca ngaphandle kokungcola kuyavavanywa.

2.2.3.3 Iipropathi ze-Optical

Iipropathi ze-Optical Sport Isalathiso esibalulekileyo sophawu olucacileyo lweefilimu zokupakisha, ikakhulu kubandakanya ukuhambisa kunye ne-haze yefilimu. Ukudluliselwa kunye ne-haze yeefilimu kwakulinganiswa kusetyenziswa i-haze tester. Khetha isampulu yovavanyo kunye nomphezulu ococekileyo kwaye akukho zinqamlo, yibekeke kakuhle kuvavanyo, kwaye uyilungiselele ngekomityi ye-filting, kwaye ulinganise ifilimu kubushushu begumbi (25 ° C kunye ne-50% ye-RH). Isampulu ivavanywa amaxesha ama-3 kwaye ixabiso eliphakathi lithathwa.

2.2.3.4 Ukuluka kwamanzi

Sika ifilimu engama-30mm ngobukhulu be-45μm, yongeza i-100ml yamanzi ukuya kwi-200ml beaker, yibeke ifilimu embindini womgangatho wamanzi, kwaye ulinganise ixesha kwifilimu ukuba inyamalale [56]. Isampulu nganye yayilinganiswa amaxesha ama-3 kunye nexabiso eliphakathi lithathiwe, kwaye iyunithi yayiyimizuzu.

2.2.4 Ukulungiswa kwedatha

Idatha yovavanyo yenziwa nge-Excel kwaye icelwe kwisoftware yendalo.

2.3 Iziphumo kunye nengxoxo

2.3.1.1 Iipatheni ze-XRD ze-HPMC Iifilimu ezincinci phantsi koxinzelelo lwesisombululo sefilimu

Umzobo.2.1 XRD yeefilimu ze-HPMC phantsi komxholo ohlukileyo we-HP

I-Angle-Angle-Ray I-X-Ray Ingqwalaselo yemeko ye-crystalline ye-Crystalline yenqanaba lemolekyuli. Umzobo 2.1 yipateni yokuhluka kwe-xord yeefilimu ezincinci ze-HPMC phantsi koxinzelelo lwefilimu eyahlukileyo. Kukho iincopho ezimbini zokuhluka [57-59] (kufutshane ne-9.5 ° kunye ne-20.4 °) kwifilimu ye-HPMC kwinani. Inokubonwa kumzobo olwanda kwe-HPMC, iincopho ezahlukeneyo zefilimu ye-HPMC malunga ne-9.5 ° kunye ne-20.4 ° aphuculwe kuqala. Kwaye ke kwenziwe buthathaka, inqanaba lokwenza ulungiselelo lweemolekyuli (ulungiselelo olwe-odod) lokwanda kwaye lancipha. Xa uxinzelelo luyi-5%, ulungelelwaniso olucwangcisiweyo lweemolekyuli ze-HPMC lilungisa. Isizathu sokungasentla kunokuba yinto yokuhlaziywa kwe-HPMC, inani leenyoka kwi-nuclei kwimozulu yefilimu enyukayo, ngaloo ndlela esenza ilungiselelo le-HPM Moleculamu rhoqo. Xa uxinzelelo lwe-HPMC lungaphezulu kwe-5%, incopho ye-XRRD yefilimu yefilimu. Ukusuka kwindawo yokujonga ilungiselelo le-molecular thein, xa uxinzelelo lwe-HPMC lukhulu kakhulu, i-viscosity yesisombululo sefilimu iphezulu kakhulu, esenza ukuba kube nzima ukuhanjiswa kweefilimu ze-HPMC kunciphe.

2.3.1.2 Iipropathi zoomatshini beefilimu ze-HPMC ezincinci phantsi koxinzelelo lwesisombululo sefilimu.

Amandla e-sunseng kunye ne-Elongition kwifilimu isetyenziswa njengezikhuthazo zokugweba iipropathi zayo, kwaye amandla anencasa zibhekisa kuxinzelelo xa ifilimu ivelisa i-subformation yeplastiki ephezulu. I-Elongition kwikhefu ngumyinge wokufuduswa kobude bentsusa yefilimu kwikhefu. Umlinganiso weepropathi zoomatshini wefilimu unokugweba isicelo sayo kwezinye iindawo.

Umzobo.2.2 Iziphumo zomxholo owahlukileyo we-HPMC kwiipropathi zoomatshini weefilimu ze-HPMC

Ukusuka kwi-Fig. 2.2, Ukutshintsha kwendlela yamandla e-thensle kunye ne-elongwetion kwi-HPMC phantsi koxinzelelo lwefilimu kunye ne-elongwetion kwifilimu ye-HPMC yenzelwa isisombululo sefilimu ye-HPMC. Xa ukugxila kwesisombululo yi-5%, iipropathi zoomatshini beefilimu ze-HPMC zingcono. Kungenxa yokuba xa ugxininiso lwefilimu lusezantsi, isisombululo se-velosity seluphantsi, ukunxibelelana phakathi kwemilongo ibuthathaka, kwaye iimolekyuli zingacwangciswanga, kwaye i-crystalizalization iphantsi kwaye iipropathi zayo zihlwempuzekile; Xa uxinzelelo lwefilimu lwefilimu yi-5%, iipropathi zoomatshini zifikelela kwixabiso elifanelekileyo; Njengoko uxinzelelo lolwelo lwefilimu luyaqhubeka ukwanda, ukuphosa kunye nokuxandwa kwesisombululo kuya kuba nzima ngakumbi kwifilimu ye-HPMC kunye neziphene ezingaphezulu [60], kukhokelela ekunciphiseni kweefilimu ze-HPMC. Ke ngoko, ukuxinana kwe-5% yesisombululo sefilimu sefilimu yeyona ifanelekileyo. Ukusebenza kwefilimu efunyenweyo kuyangcono.

2.3.1.3 Iipropathi ze-Optical ze-HPMC Fightmus ezinqabileyo eziphantsi koxinzelelo lwesisombululo sefilimu

Kwifilimu yokupakisha, ukuhambisa ukukhanya kunye ne-haze yimilinganiselo ebalulekileyo ebonisa ukungafihli ifilimu. Umzobo 2.3 Ubonisa iindlela zokutshintsha kokudlulisela kunye ne-haze yeefilimu ze-HPMC phantsi koluntu olwahlukileyo lwefilimu. Inokubonwa kumzobo olwandiso lwendlela yokuhamba kwefilimu ye-HPMC, ukuhambisa ifilimu ye-HPMC ngokuthe ngcembe, kwaye i-haze yonyuke kakhulu ngokunyuka kwesisombululo sefilimu.

Umzobo.2.3 Isiphumo somxholo owahlukileyo we-HPMC kwipropathi ye-HPMC yeefilimu ze-HPMC

Kukho izizathu ezibini eziphambili: Okokuqala, ukusuka kwimbono yenani lenani lesigaba esisasazwayo, xa uxinzelelo luphantsi, inani lenani linempembelelo enkulu kwiimpawu ezibonakalayo zezinto [61]. Ke ngoko, ngokuphulwa kokuxinana kwesisombululo sokwenza ifilimu ye-HPMC, izidlo zefilimu ziyancitshiswa. Ukukhanya okudlulayo kunciphile kakhulu, kwaye i-haze yanda kakhulu. Okwesibini, kuhlalutyo lwenkqubo yokwenza ifilimu, kunokuba ngenxa yokuba ifilimu yenziwa sisisombululo sendlela yokwakha ifilimu. Ukunyuka kobunzima be-Elongwation kukhokelela ekuncipheni kweyona filimu yefilimu kunye nokwehla kweepropathi zefilimu ye-HPMC.

2.3.1.4 Ukungathobeli kwamanzi kwi-HPMC yeefilimu ezincinci phantsi koxinzelelo lwefilimu olwahlukileyo

Ukuzenzela amanzi ezothusayo kweefilimu ezinyibilikayo zamanzi kuhambelana nokugxilwa kwevidiyo. Sika iifilimu ezingama-30mms × 30mm ezenziwe ngefilimu eyahlukileyo, kwaye phawula ifilimu "+" ukulinganisa ixesha lefilimu ukuba inyamalale ngokupheleleyo. Ukuba ifilimu icoca okanye inamathela kwiindonga zomlibi, iphinda iphinde. Umzobo 2.4 Ngumzobo womkhondo womhlaba wokuhluma kwamanzi kwiifilimu ze-HPMC phantsi kweendlela ezahlukeneyo zefilimu. Inokubonwa kumzobo olwanda ukugxila kwefilimu, ixesha elinyibilikayo lamanzi eefilimu ze-HPMC liba ngaphezulu, libonisa ukuba ukubethwa kwamanzi kweefilimu ze-HPMC zinciphisa. Icacisiwe ukuba isizathu sinokuba yiyo ngokuphunyezwa koxinzelelo lwefilimu yefilimu ye-HPMC, i-viscosity yesisombululo iyasomeleza ifilimu yefilimu ye-HPMC emanzini kunye nokuhla kwe-strabing yamanzi.

Umzobo

2.3.2 Iziphumo zobushushu befilimu kwi-HPMC Fight

2.3.2.1 Iipateni ze-XRD ze-HPMC Fight Fight Fight Fights kwiqondo lokuhlala lefilimu

Umzobo.2.5 XRD yeefilimu ze-HPMC phantsi kweefilimu zefilimu ezahlukeneyo

Umzobo 2.5 ubonakalisa iipateni ze-XRD ze-HPMC Fight Fight Fights kwiqondo lokuhlala lefilimu. Iincopho ezimbini zokuhluka kwi-9.5 ° kunye ne-20.4 ° zahlalutywa kwifilimu ye-HPMC. Ukusuka kwimbono yobunzulu beencopho zokumahluka kwefilimu, ukunyuka kweefilimu, iincopho zokumahlukana kwiindawo ezimbini zanda zaza zakhula kwaye zancipha. Xa ubushushu bokwenza ifilimu yayingama-50 ° C, ulungiselelo olu-odolweyo lweeMolekyuli ze-HPMC ukusuka kwimpembelelo ye-homogeous ye-homogeous, xa iqondo lokukhula liphezulu, kwaye ikristali inzima; Njengoko ubushushu bokwenza ifilimu ngokuthe ngcembe bunyuka ngokuthe ngcembe, umyinge wonyuso lwe-nucleing, intshukumo ye-molecular thein iyalungiswa ngokulula, kwaye kulula kakhulu kwi-nucleling nucukisi ngohlobo, kwaye kulula ukwenza i-crystallization, ke i-crystalization iya kufikelela kwixabiso eliphezulu; Ukuba iqondo lobushushu lefilimu liphezulu kakhulu, intshukumo yemolekyuli inobundlobongela, ukwenziwa kwe-nucleus inzima, kwaye ukumiselwa kokusebenza kwenyukliya kusezantsi kwaye kunzima ukwenza amakristali [62,63]. Ke ngoko, i-crystallity yeefilimu ze-HPMC inyuka kuqala kwaye incipha ngokunyuka kweqondo lokwenza ifilimu.

2.3.2.2 Iipropathi zoomatshini beefilimu ze-HPMC ze-HPMC kwiifilimu ezahlukeneyo zefilimu

Utshintsho lweqondo lokwenza ifilimu luya kuba nenqanaba elithile lempembelelo kwiipropathi zoomatshini befilimu. Umzobo 2.6 Ibonisa indlela yokutshintsha kwendlela yamandla e-thensle kunye ne-elongwetion kwikhefu leefilimu ze-HPMC kwiqondo lokuhlala lefilimu. Kwangelo xesha, kubonisa imeko yokwanda kuqala kwaye emva koko inciphe. Xa iqondo lokushisa lefilimu yayingama-50 ° C, amandla e-subile kunye ne-Elongile kwiFleyimu ye-HPMC ifikelele kwelona maxabiso liphezulu, eyayingama-116 MPA kunye ne-32%, ngokulandelelana.

Umzobo.2.6 Isiphumo seqondo lokuqulunqa ifilimu kwiipropathi zoomatshini weefilimu ze-HPMC

Ngokwembono yelungiselelo lemolecula, kokukhona ulungelelwaniso lweeMolecule, olona nqabileyo lwamandla [64]. Ukusuka kwi-Fig. Iipateni ze-2,5 ze-tsg kwiifilimu ze-HPMC kwiqondo lokwenza ifilimu, linokubonwa ukuba ngokunyuka kweefilimu zokulinganisa iifilimu, ulungiselelo olucwangcisiweyo lweemolekyuli ze-HPMC kuqala lunyuke emva koko luyancipha. Xa iqondo lobushushu lefilimu lingama-50 ° C, inqanaba lokucwangciswa kwe-Reded yeyona nto inkulu, ngoko ke amandla e-HPMC anyukayo ayonyukayo aze anciphise ukwanda kweqondo lokushisa lefilimu, kwaye elixabiso eliphezulu livela kwiqondo lokushisa lefilimu engama-50. I-Elongition ekhefu ibonisa imeko yokwanda kokuqala kwaye emva koko inciphise. Isizathu sinokuba yiyo ngokunyuka kweqondo lokushisa, ulungelelwaniso lweMolecus lunyuke emva koko luyancipha, kwaye isakhiwo sekristali eyenziwe kwi-polymer matrix ye-polymer ichithwe kwi-polymer ye-polymer ye-polymer. KwiMatrix, isakhiwo esidibeneyo somnqamlezo senziwa, esidlala indima ethile ekuchitheni [65], ngaloo ndlela ikhuthaza ukubekwa kwefilimu ye-HPMC ukuba ivele kwi-° CARME.

2.3.2.3 Iipropathi ezizayo kwiifilimu ze-HPMC kwi-heatratings eyahlukileyo

Umzobo 2.7 Ngaba ijikajika lemigangatho yeempawu ze-HPMC kwiifilimu ze-HPMC kwi-heatrongs yokwakha amaqondo obushushu. Ingabonwa kumzobo ngokunyuka kweqondo lokwenza ifilimu, ukuhambisa ifilimu ye-HPMC ngokuthe ngcembe, i-haze ngokuthe ngcembe iyancipha, kunye neepropathi zefilimu ze-HPMC ngokuthe ngcembe.

Umzobo.2.7 Isiphumo seqondo lokwenza ifilimu kwipropathi ye-HPMC

Ngokwempembelelo yeqondo lobushushu kunye neemolekyuli zamanzi kwifilimu [66], xa amaqondo obushushu aphantsi, iimolekyuli zamanzi ezikwi-HPMC ngendlela eboshwe ngokuthe ngcembe, kwaye le i-HPMC ikwimeko yeglasi. Ukuziqeqeshwa kwefilimu fomu ye-HPMC, emva koko kwasasazeka imingxunya kwimingxunya emva kokudinwa kokukhanya [67], ngoko ke ukugqithisa ukukhanya kwefilimu kuphantsi kwaye i-haze iphantsi; Njengoko iqondo lobushushu liyanda, amacandelo e-MPMUROR ye-HPMC aqala ukuhamba, imingxunya eyenziwa emva kokuba izibongozo zamanzi zizaliswe, kwaye imingxunya iphuculwa, ke ukusasazeka kokukhanya kwefilimu kuyanda kwaye i-haze iyancipha.

2.3.2.4 Ukuzalwa kwamanzi kwi-HPMC yeefilimu ze-HPMC kwiqondo lokuhlala lefilimu

Umzobo 2.8 Ibonisa i-curves yokuzenzela amanzi e-HPMC kwi-fields eyahlukileyo yokwakha amaqondo obushushu. Ingabonwa kumfanekiso ukuba ixesha lokuzola amanzi le-HPMC linyuka ngokunyuka kwefilimu, oko kukuthi, ukulala kwamanzi kwiifilimu ze-HPMC kuya kuba mandundu. Ngokwanda kweqondo lobushushu lefilimu, inqanaba lokuphuma kwefilimu lemolekyuli lamanzi kunye nenqanaba lokuhluthwa liyakhawulezisa, ilungiselelo le-molecular lincitshisiwe, kwaye ilungiselelo le-molecular lincitshisiwe, lenza ukuba kube nzima kakhulu kwiimolekyuli zamanzi. Ukungathobeli kwamanzi kuncitshisiwe.

Umzobo

2.4 Isishwankathelo sale sahluko

Kwesi sahluko, i-Hydroxypropyl Methylcelceltulose yasetyenziswa njengezixhobo ze-RWS ukulungiselela ifilimu ye-HPMC ye-HPMC yamanzi ngesisombululo sendlela yokwakha ifilimu. I-crystallies yefilimu ye-HPMC yahlalutywa ngumbambiso we-xrd; Iipropathi zoomatshini befilimu ye-HPMC ye-HPMC yavavanywa kwaye zahlalutywa ngumatshini wokuvavanya indalo iphela, kunye neepropathi zamehlo zefilimu ye-HPMC zahlalutywa yi-haze yothumelo. Ixesha lokuchithwa kwamanzi (ixesha lokuzola amanzi) lisetyenziselwa ukuhlalutya ukuluka kwamanzi. Izigqibo ezilandelayo zithathwa kolu phando lungentla:

1) Iipropathi zoomatshini beefilimu ze-HPMC zaza zanda kwaye zancitshiswa kukonyuka koxinzelelo lwesisombululo sefilimu, kwaye sasanda ekuqaleni kweqondo lobushushu befilimu. Xa uxinzelelo lwe-HPMC yefilimu yefilimu yayiyi-5% kwaye iqondo lobushushu lefilimu yayingama-50 ° C, iipropathi zoomatshini befilimu zilungile. Ngeli xesha, amandla anencasa malunga ne-116MPA, kunye ne-elongiya kwikhefu malunga ne-31%;

2) Iipropathi zamehlo ze-HPMC Iifilimu ze-HPMC zihla ngokunyuka kwesona sombuso sefilimu, kwaye inyuka ngokuthe ngcembe ukunyuka kobushushu bokwenza ifilimu; Qwalasela ngokuqonda ukuba ukugxininiswa kwesisombululo sefilimu akufuneki kudlule kwi-5%, kwaye iqondo lokwenza ifilimu akufuneki lingadli i-50 ° C

3) Ukuzenzela amanzi ezothumelo ze-HPMC kubonisa indlela esezantsi yokwanda kwesisombululo sefilimu kunye nokunyuka kobushushu bokwenza ifilimu. Xa uxinzelelo lwe-5% ye-HPMC yefilimu yefilimu kunye neqondo lokwenza ifilimu engama-50 ° C lasetyenziswa, ixesha lokuchithwa kwamanzi lefilimu yayingama-55 imiz.

ISAHLUKO 3 IINKQUBO ZE-PARSELZEZISI KWI-HPMC AMANZI YENKQUBO YOKUGQIBELA

3.1 Intshayelelo

Njengohlobo olutsha lwe-Polymer yeNdalo yePolmer ye-HPMC ye-HPMC ye-HOLMC yephakheji inethemba elihle lophuhliso. I-HydroxyPOpyl Methylcelcelcelose yindawo ye-seluplose yendalo. Ayisiyo inetyhefu, engangcolisi, ihlaziyekile, izinzile kwaye inezinto ezilungileyo. Ukunyibilika kwamanzi kunye nokwenza ifilimu, yindawo enamanzi efilimu enamandla.

Isahluko sangaphambili sixoxe kulungiselelo lwefilimu ye-HPMC ye-HPMC ngokusebenzisa i-HydroxlyAse njengesisombululo sefilimu yefilimu, kunye nesimo sefilimu sefilimu kwifilimu ye-Hydropylcelose ifilimu yephakheji. Impembelelo yokusebenza. Iziphumo zibonisa ukuba amandla akwiifilimu amalunga ne-116MPA kunye ne-Elonglong kwikhefu ngama-31% phantsi kweemeko zenkqubela phambili. Ubunzima beefilimu ezinjalo zihlwempuzekile kwezinye iinkqubo kwaye zifuna ukuphuculwa ngakumbi.

Kwesi sahluko, i-HydroxyPopyl Methylcelceltulose isasetyenziswa njengezixhobo eziluhlaza, kwaye ifilimu yephakheji enyibilikayo ilungiselelwe isisombululo sendlela yokwakha ifilimu. , i-Elongiya kwikhefu), iipropathi ezibonakalayo (i-distemitance, haze) kunye nomoya wokuluka amanzi.

3.2 ISebe Lovavanyo

3.2.1 Izinto zovavanyo kunye nezixhobo

Itheyibhile 3.1 Izinto zovavanyo kunye neenkcukacha

Itheyibhile 3.2 Izixhobo zovavanyo kunye neenkcazo

3.2.2 Ukulungiselela isampulu

1) Ukulinganisa: Ukulinganisa inani elithile le-hydroxypropyl methylcelculose (5%) kunye ne-shority (0.05%, i-0,05%, i-0.15%, i-0.15%, i-0,45%, i-0,25%, i-0,45%, i-0,45%).

2) Ukuchithwa: Yongeza i-HydroxyPyl Methylcelceluplose kwi-deion ye-deeersce kwi-ofisi efanelekileyo, ivuseleleke kubushushu obuqhelekileyo kunye noxinzelelo kude kube lelo i-glycerol okanye i-tharebil kumaqhezu amaninzi ngendlela eyahlukeneyo ngokulandelelana. Kwi-hydroxypropyl methylcelcelsese isisombululo, ukuvuselela ixesha lokulinganisa ukudityaniswa, kwaye mayiyekele imizuzu emi-5 (i-DeFoimaing) ukufumana uxinzelelo oluthile lwefilimu.

I-3) Ukwenza ifilimu: Ukutyibilika ifilimu yefilimu kwisitya se-petrit kwaye iphose ifilimu, kwaye emva koko siyime i-oveni eyomileyo kwaye siyibe ifilimu yokwenza ifilimu engama-45 μm. Emva kokuba ifilimu ibekwe kwibhokisi eyomileyo yokusetyenziswa.

3.2.3 uphawu kunye novavanyo lwentsebenzo

3.2.3.1 Uhlalutyo lwe-infraper

I-Infrad Durproscopy (fir) yindlela enamandla yokwaphula amaqela asebenzayo akwimo yemolekyuli kunye nokuchonga imisebenzi esebenzayo. I-Viecring ye-infrared yokufumana ifilimu ye-HPMC yalinganiswa ngokusebenzisa i-NOOLL 5700 Translation Inguqu ye-Inchroment ye-infraffer eveliswe ngumbutho we-thertoeletric. Indlela yefilimu yefilimu yayisetyenziswa kolu lungelo, uluhlu lweskena yayiyi-500-40 cm-1, kunye nenani lezifinyiso zangu-50.

3.2.3.2.2.2.2.2.2.2.2.2.2 Uhlalutyo olubanzi lwe-x-ray (xrd)

3.2.3.3 Ukuzimisela kweepropathi zoomatshini

Amandla obuzinile kunye ne-Elongition kwikhefu lefilimu zisetyenziswa njengeparamitha yokugweba iipropathi zayo. I-Elongition kwikhefu ngumyinge wokufuduswa kobude bentsusa xa ifilimu yaphukile, kwi%. Sebenzisa i-Intern (5943) encinci yovavanyo lwe-nitedminial versile yovavanyo lwe-Inron (i-shanghai), ngokuhambelana neemeko zovavanyo ezingama-25, zenza iisampulu ezinobunzima obungapheliyo kwaye zivavanywa ngaphandle kokungcola.

3.2.3.4 Ukuzihlaziya kweepropathi ezichanekileyo: ngokufanayo ne-2.2.3.3

3.2.3.5 Ukuzimisela kokungasebenzi kwamanzi

Sika ifilimu engama-30mm ngobukhulu be-45μm, yongeza i-100ml yamanzi ukuya kwi-200ml beaker, yibeke ifilimu embindini womgangatho wamanzi, kwaye ulinganise ixesha kwifilimu ukuba inyamalale [56]. Isampulu nganye yayilinganiswa amaxesha ama-3 kunye nexabiso eliphakathi lithathiwe, kwaye iyunithi yayiyimizuzu.

3.2.4 Ukulungiswa kwedatha

Idatha yovavanyo yenziwa nge-Excel, kwaye igrafu yathunyelwa ngesoftware yendalo.

3.3 Iziphumo kunye nengxoxo

3.3.1 Iziphumo ze-glycerol kunye ne-shorbil kwi-Infrad Spectrum yeefilimu ze-HPMC

(a) i-glycerol (b) i-sorbil

Umzobo.3.1 ft-ir yeefilimu ze-HPMC phantsi kwe-glycerol eyohlukileyo

I-Infrad Durproscopy (fir) yindlela enamandla yokwaphula amaqela asebenzayo akwimo yemolekyuli kunye nokuchonga imisebenzi esebenzayo. Umzobo 3.1 bonakalisa i-infrared fictra ye-HPMC yeefilimu ze-HPMCIL kunye nokongezwa kwe-glycelal kunye ne-sorbilil. Ingabonwa kumzobo oqingqiweyo se-skeleton fictory yeefilimu ze-HPMC ikakhulu kwiingingqi ezimbini: 2600 ~ 3700cm-1 kunye ne-1750 ~ 3418cm-1

Iibhendi ezikufuphi zibangelwa kukuntywila kwe-OH ye-OH ye-OH, i-2935cm-1 yincopho ye-adch2, i-1050cm-1 yipinki ye-hydroxyl, kunye ne-1657cm-1 yincopho ye-HydroxlyPropyP. Incopho ye-Anserngection yeQela le-hydroxyl kwi-sporaction yenkqubo yesakhelo, i-945cm-1 yincopho eqengqelekayo ye-Cek3 [69]. I-Peipks zokufundwa nge-1454cm-1, 1373cm-1, 1315cm-1 kwaye i-945cm-1 ibelwa i-asymmetric, i-945cm-1 yayo kunye ne-18]. Emva kweplastiki, akukho zincopho zintsha zokufumana ifilimu, ebonisa ukuba i-HPMC ayikazenzi utshintsho olufanelekileyo, oko kukuthi, iplastikhi ayitshabalalisi ubume bayo. Ngongezwa kwe-glycerol, i-chibiction eshukumayo ye-3418CM-1 yefilimu ye-HPMC ye-1650cm-1 ye-Able-1 ye-Able-1 ye-Able- kunye ne-SHDROCYL yamaqela e-hydroxyl yenze buthathaka; Ngokuqulunqwa kwe-sorbiol kwifilimu ye-HPMC, i-UT-I-OROR STACTE nge-3418cm-1 ebuthathaka, kunye neencopho ze-absen nge-1657cm-1 yenzekile. . Utshintsho lwezi zincopho zokufunxa kubangelwa ikakhulu ziziphumo zokungazinzi kunye ne-hydrogen ye-hydrogen ye-hydrogen, eyenza ukuba batshintshe kunye ne-qubiss -ch3 ye-andv3 and -ch2. Ngenxa encinci, ukufakwe kwezinto zemolekyuli zithintela ukwenziwa kweembophelelo ze-hydrogen ye-hydrogen, ngoko ke amandla efilimu yefilimu eplastiki ancipha [70].

3.3.2 Iziphumo ze-glycerol kunye ne-shorbil kwipateni ye-XRRD yeefilimu ze-HPMC

(a) i-glycerol (b) i-sorbil

Umzobo.2.2 XBD yeefilimu ze-HPMC phantsi kwe-glycerol eyahlukileyo okanye i-sorbitimom i-windon

I-Angle-Angle-ray ye-X-ray (i-XRD) ihlalutya imeko ye-crystalline yenqanaba kwinqanaba lemolekyuli. I-X-ray ye-X-ray disccracpreter ye-ARL / Uhlobo lweNkampani ye-thermo ARMO kwi-Switzerland yayisetyenziselwa isigqibo. Umzobo 3.2 ziipatheni ze-XRD zeifilimu ze-HPMC ezinezongezelelo ezahlukeneyo ze-glycerol kunye ne-shorbil. Ngeyongezwa kwe-glycerol, ubukhulu be-pencoction ye-peroction nge-9.5 ° kunye ne-20.4 ° ibala elibuthathaka; Ngokuqulunqwa kwe-shoreti, xa imali eyongezelelweyo yayiyi-0.15%, incopho ye-Peak, kwaye i-Peak eyahlukileyo iphantsi kwefilimu ye-HPMC ngaphandle kwe-HPMC ngaphandle kweSotribil. Ngongezwa okuqhubekayo kwe-Sorbiol, i-Peak eyahlukileyo nge-9.5 Kungenxa yokuba ukongezwa kweemolekyuli ezincinci ze-glycerol noSorbibil kuphazamisa ulungiselelo olucwangcisiweyo lweemolekyuli kwaye lutshabalalise imeko yekristali yasekuqaleni, ngaloo ndlela kunciphisa i-crystalization yefilimu. Ingabonwa kumzobo ophembelela kwi-crystalling ye-HPMC, ebonisa ukuba i-glycerol kunye ne-HPMC ihambelana ngokuchanekileyo, ngelixa i-jorebil kunye ne-HPMC ayinakuphela. Ukusuka kuhlalutyo lwendlela yeplastiki, iSorbilil inolwakhiwo lwe-right olufana neso sesellulose, kunye nefuthe elibuthathaka kwimolekyuli kunye neemolekyuli ezibuthathaka, ke ayinampembelelo encinci kwikristali ye-seluplose.

[48].

I-3.3.3 Iziphumo ze-glycerol kunye ne-sorbils kwiipropathi zoomatshini beefilimu ze-HPMC

Amandla obuzinile kunye ne-Elongition kwikhefu isetyenziselwa iiparamitha zokugweba iimpawu zayo zoomatshini, kwaye umlinganiso weepropathi zoomatshini unokugweba isicelo sayo kumacandelo athile. Umzobo 3.3 bonisa utshintsho kumandla amanye kunye ne-elongwetion kwikhefu leefilimu ze-HPMC emva kongeza iiplastiki.

Umzobo.3.3 isiphumo se-glycerol okanye i-sorbiormon kwiipropathi zomatshini weefilimu ze-HPMC

Ingabonwa kumzobo 3.3 (a) ukuba ngokongezwa kwe-glycerol, i-elongwer kwifilimu ye-HPMC kuqala inyuke ngokukhawuleza, emva koko inyuke kancinci kwaye iqhubeke incipha. I-Elongication kwikhefu lefilimu ye-HPMC yanda kuqala emva koko inciphile, kuba i-glycerol ineziphumo ezizezona ze-hydrophilic, ezona zinto zenza ukuba izinto ezibonakalayo zinemiphumo eqinileyo [71], ngenxa yoko ukuphucula ukuguquguquka kwefilimu. Ngokunyuka okuqhubekayo kwe-Glycerol ukongezwa, i-elongwetion kwi-HPMC iyancipha, kungenxa yokuba i-Glycerol yenza ukuba i-Macromoler ye-HPMC inkulu, ke ifilimu icinezelwe ifilimu. Isizathu sokuncipha okukhawulezayo kwamandla e-thensle yi: Ukongezwa kweemolekyuli ezincinci kuphazamisa ulungiselelo olusondeleyo phakathi kwe-HPMC MOLECRUS, kwaye inciphise amandla e-subile yefilimu; Amandla anobungqingili anyuka kancinci, kwimbono ye-molecular thein, i-glycerol efanelekileyo yonyusa ukuguquguquka kweempondo zePolymer Molecrion, kwaye yenza amandla e-thensile yefilimu anyuka kancinane; Nangona kunjalo, xa kukho i-glycerol enkulu, imixokelelwane ye-molecular icelwe kwangaxeshanye njengoko ulungelelwaniso lwefilimu [72], olungela i-crystalment yefilimu yefilimu ye-HPMC. Kuba isiphumo sokucheba inkcitho sisekuphosweni yamandla abunjiwe efilimu ye-HPMC, isixa se-glycerol esongeziweyo akufuneki sibe kakhulu.

Njengoko kubonisiwe kumzobo 3.3 (b), ukongezwa kwe-shorbiol, i-elongiya kwikhefu lefilimu ye-HPMC kuqala yancipha emva koko inciphile. Xa inani le-SORTATIOL yayiyi-0.15%, i-elongition kwifilimu ye-HPMC ifikelele kuma-45%, kwaye emva koko i-elongition yekhefu ngokuthe ngcembe yancitshiswa kwakhona. Amandla e-thanset ancipha ngokukhawuleza, emva koko axhase ngokujikeleza i-50MP ngokungezwa kweSorebiol. Ingabonwa ukuba xa inani lexabiso longezwa i-sorbibil yi-0.15%, impembelelo yeplastiki yeyona ilungileyo. Kungenxa yokuba ukongezwa kweemolekyuli ezincinci ze-shorbibil ukuphazamisa amalungiselelo eemolekyuli, ukwenza umsantsa phakathi kweemolekyuli, ke iimolethi zilula ukuhambisa ifilimu ekwakheni kunye namandla aphezulu. Njengoko inani le-thabibiol laqhubeka lisanda, i-elongiya kwifilimu iphindaphindeke kwakhona, kuba iimolethi ezincinci zeSorabil zazisasazeke ngokupheleleyo phakathi kwe-macromolecules kunye nokwehla kwifilimu.

Ukuthelekisa iziphumo zeplastiki ze-glycerol kunye ne-shorbil yeefilimu ze-HPMC, ukongeza i-0.15% i-glycerol inokunyusa i-elonglong kwikhefu kwi-50%; Ngelixa usongeza i-0.15% i-Sorbillion inokunyusa kuphela i-slongetion kuphela yefilimu Ixabiso lifikelela malunga ne-45%. Amandla amanxuwa ayancipha, kwaye ukwehla kwakukuncinci xa kongezwa i-glycerol. Ingabonwa ukuba isiphumo seplastiki se-glycerol kwifilimu ye-HPMC ilunge ngakumbi kuneso se-sorbibil.

3.3.4 Iziphumo ze-glycerol kunye ne-shorbils kwipropathi ye-HPMC yeefilimu ze-HPMC

(a) i-glycerol (b) i-sorbil

Umzobo.3.4 Isiphumo se-glycerol okanye i-sorbitical yepropathi ye-HPMC yeefilimu

Ukukhanya okukhanyayo kunye ne-haze yimilinganiselo ebalulekileyo yokungafihli ifilimu yokupakisha. Ukubonakala kunye nokucaca kweempahla eziphathelweyo ikakhulu kuxhomekeka ekukhanyiseni ukukhanya kunye ne-haze yefilimu yephakeji. Njengoko kubonisiwe kuMfanekiso 3.4, ukongezwa kwe-glycerol kunye ne-thambil zombini kuchaphazela iipropathi ze-HPMC, ngakumbi i-haze. Umzobo 3.4 (a) yigrafu ebonisa isiphumo se-Glycerol ukongezwa kwiipropati ze-HPMC. Ngeyongezwa kwe-glycerol, ukuhambisa iifilimu ze-HPMC kuqala kwaye kuncitshisiwe, ukufikelele kwixabiso eliphezulu 0.25%; I-haze yanda ngokukhawuleza kwaye ihamba kancinci. Ingabonwa kolu hlalutyo lungentla ukuba isixa se-glycerol yi-0.25%, iipropathi ezibonakalayo zefilimu zingcono, ke isixa esongeneyo se-glycerol akufuneki sidlule kwi-0.25%. Umzobo 3.4 (b) yigrafu ebonisa ifuthe longezwa kwe-sotrinel kwiipropathi ze-HPMC. Ingabonwa kumzobo ukuba ngokongezwa kwe-shorbil, i-haze yeefilimu ze-HPMC inyuka kuqala, emva koko inciphise kancinci kwaye inyuke kancinci kwaye inyuke ize inyuke kuqala kwaye inyuke kuqala kwaye inyuke. Yehlile, kwaye ukukhanya okukhanyayo kunye ne-haze yavele ipikisi ngaxeshanye xa inani le-SORTAL yayingu-0.45%. Ingabonwa ukuba xa inani lexabiso longezwa i-sorbibil liphakathi kwe-0.35 ne-0.45%, iipropathi zayo ezibonakalayo zingcono. Ukuthelekisa iziphumo ze-glycerol kunye ne-shorbils kwipropathi ye-HPMC yeefilimu ze-HPMC, inokubonwa ukuba i-sorbibil ayinampembelelo encinci kwiimpawu zamehlo zefilimu.

Ngokubanzi, izixhobo zokukhanya okuphezulu zinokufumana i-haze iphantsi, kwaye ngokuchaseneyo, kodwa oku akusoloko kunjalo. Ezinye izixhobo zinokutshintsha okuphezulu kodwa zininzi izinto eziphakamileyo ze-haze, ezinje ngeefilimu ezinqabileyo njengeglasi ebandayo [73]. Ifilimu elungiselelwe kolu vavanyo inokukhetha isiphithiphithi esifanelekileyo kwaye sidibanise inani ngokweemfuno.

I-3.3.5 Iziphumo ze-glycerol kunye ne-sorbiol kwi-sloubing yamanzi yeefilimu ze-HPMC

(a) i-glycerol (b) i-sorbil

Umzobo.3.5 Isiphumo se-glycerol okanye i-sorbitilomuldon yamanzi ye-Solity ye-HPMC Fight

Umzobo 3.5 ubonakalisa isiphumo se-glycerol kunye ne-sorbiol kwi-smoubing yamanzi yeefilimu ze-HPMC. Ingabonwa kumzobo owonyuse umxholo weplastiki, ixesha lokuzenzela amanzi lefilimu ye-HPMC lihlala lingaphezulu kwefilimu ye-HPMC kuneSotribil. Isizathu sokuba i-HydroxyPyl Methylcelcelgalose inobukho bamanzi obuhle ngenxa yobukho benani elikhulu lamaqela e-hydroxyl kwimolekyuli yayo. Ukusuka kuhlalutyo lwe-infrared spectum, inokubonwa ukuba ngokongezwa kwe-glycerol kunye ne-shorbilical, i-hydroxyl ipilisi ye-HPMC MOLECS inciphisa i-HPMC MOLINS, ngoko ke ifilimu yamanzi yefilimu ye-HPMC iyancipha.

3.4 Amacandelo esi sahluko

Ngolu hlalutyo lwentsebenzo engaphezulu kweefilimu ze-HPMC, inokubonwa ukuba i-pustcerol kunye ne-stribil iphucule iipropathi zoomatshini beefilimu ze-HPMC kwaye zandise i-slongetion yefilimu. Xa ukongezwa kwe-glycerol yi-0.15%, iipropathi zoomatshini beefilimu ze-HPMC zilungile, amandla amathombile malunga ne-60mpa, kunye ne-elonghation ekhefu malunga ne-50%; Xa ukongezwa kwe-glycerol yi-0.25%, iipropathi ezibonakalayo zingcono. Xa umxholo we-Sorbiol yi-0.15%, amandla e-thensen yefilimu ye-HPMC imalunga ne-55MPA, kunye ne-elonglong, kunye ne-elonghation kwi-45%. Xa umxholo we-sorbibil yi-0.45%, iipropathi ezibonakalayo zefilimu zingcono. Zombini iiplasitiki zinciphise ukubenzela amanzi kweefilimu ze-HPMC, ngelixa i-sorbibil yayinegalelo elincinci kwi-solional ye-HPMC yeefilimu ze-HPMC. Ukuthelekisa kweziphumo zoomatshini beeplasitiki ezibini kwipropathi yeefilimu ze-HPMC kubonisa ukuba isiphumo se-glycerol kwiifilimu ze-HPMC zingcono kuneso se-sorebiol.

ISAHLUKO 4 IINKQUBO ZE-ARDS YOKUGQIBELA KWI-HPMC YAMANZI YOKUGQIBELA

Intshayelelo

I-Hydroxypropyl Methylcelceluplose iqulethe amaqela amaninzi e-hydroxyl kunye namaqela e-hydroxyproposy, ngoko ke inomoya ofanelekileyo wamanzi. Eli phepha lisebenzisa isonoba lalo elilungileyo lokulungiselela inoveli eluhlaza kunye nendawo ekumgangatho olwenziwe ngamanzi. Kuxhomekeka ekusetyenzisweni kwefilimu enyibilikayo yamanzi, ukutshitshiswa ngokukhawulezileyo kwefilimu enyibilikayo kuyadingeka kwizicelo ezininzi, kodwa ngamanye amaxesha ukulibaziseka kuye kufundiswa [21].

Ke ngoko, kwesi sahluko, i-glutaraldehyde isetyenziswa njenge-arhente yokunxibelelanisa ifilimu yephakheji ye-hydroxyproplose, kwaye umphezulu wawo unxulumene nokunciphisa ifilimu yefilimu kwaye ulibazise ixesha lokulinganisa amanzi. Iziphumo zongezwa kwevolumu ye-glutaraldehyde ye-GLTHHDDE yevolumu, iipropathi zoomatshini kunye neempawu ezibonakalayo ze-hydroxlypropyl methylcelcelcelse ikakhulu.

4.2 Uvavanyo

4.2.1 Izinto zovavanyo kunye nezixhobo

Itheyibhuli 4.1 Izinto zovavanyo kunye neenkcazo

4.2.2 Ukulungiswa okutsha

1) Ukulinganisa: Ukulinganisa inani elithile le-hydroxypropyl methylcelcelcelsulose (5%) ngebhalansi ye-elektroniki;

2) Ukuchithwa: I-Hodroxypropyl ye-Methylcelcelcelsulose yongezwa kumanzi alungiselelwe i-deenion kunye ne-0.19% ye-GLTHANCOLDE (0,44%, i-0,44%), i-DeFoing), kunye nolwelo lwefilimu I-GLTHutaraldeHhyde yongezelelekile;

I-3) Ukwenza ifilimu: Ukutyibilika ifilimu yefilimu kwiglasi yeglasi kwaye iphose ifilimu eyomisa ifilimu engama-40 ~

4.2.3 uphawu kunye novavanyo lwentsebenzo

4.2.3.1 Uhlalutyo lwe-infraper

Ukunyanzelwa kwe-Inpmc Iifilimu ze-HPMC zagqitywa kusetyenziswa i-nicolet 5700 ye-metrier spectrometer eveliswe yinkampani yaseMelika ye-Thermoelectric ivale inkampani.

4.2.3.2 I-Angle-Angle-Ray Angles

I-Angle-Angle-ray ye-X-ray (i-XRD) yohlalutyo lwe-crystallization yento kwimolekyuli. Kweli phepha, i-Crystallization yefilimu yefilimu igqityiwe kusetyenziswa i-arl / tra x-ray discracracpreter eveliswe yi-thermo arl yeSwitzerland. Iimeko zokulinganisa: Umthombo we-X-ray ngumthombo we-nickel cumter cu-kcy (40 kv, 40 ma). Scan Angle ukusuka kwi-0 ° ukuya kwi-80 ° (2θ). Isantya se-Scan 8 ° / imiz.

4.2.3. UKUTHENGWA KOKUZONWABISA KWAMANZI: Ifana ne-2.2.3.4

4.2.3.4 Ukuzimisela kweepropathi zoomatshini

Sebenzisa i-Intern (5943) ubuncinci bovavanyo lwe-Tenron (i-Shanghai), ngokwe-GB13022 yeemeko zovavanyo ezingama-25, i-8% ye-RH1302-

4.2.3.5 Ukuzimisela kweepropathi ezibonakalayo

Sebenzisa ukukhanya kwe-haze tester, khetha isampulu ekufuneka uhlolwe umphezulu ococekileyo kwaye akukho zinqamlo, kwaye ulinganise ukukhanya kweqondo lokushisa (25 ° C kunye ne-50% rh).

4.2.4 Ukulungiswa kwedatha

Idatha yovavanyo yenziwa nge-Excel kwaye ithwaxwa yisoftware yendalo.

4.3 Iziphumo kunye nengxoxo

4.3.1 Ukuthathwa kwe-infrared VirtuRo ye-GLTHANAREAREHHYHHYHHYHYHHYHHY LEPMC Iifilimu

Fig.4.1 FT-IR ye-HPMC yeefilimu ze-HPMC phantsi kwe-glutaraldehyde yomxholo

I-Speen Accred Spectroscopy ikwindlela enamandla okuphawula amaqela asebenzayo akwimo yemolekyuli kunye nokuchonga imisebenzi esebenzayo. Ukwenzela ukuba uqonde utshintsho lwesakhiwo se-hydroxypropyl methylcelsulose Umzobo 4.1 Ibonisa ukuba i-infrate ye-Incy yeefilimu ze-HPMC ezinamaxabiso ahlukeneyo e-glutaraldehyde, kunye nokusebenza kweefilimu ze-HPMC

I-Piecking ye-Abrical Aoh ka-Aoh ikufuphi 3418cm-1 kunye ne-1657cm-1. Ukuthelekisa i-infrared kunye ne-UNcrolfied I-infrared Fight Fightms, inokubonwa ukuba i-GLTHANCOLDE, i-chibirical peak yeqela le-Hydroxyl kwiqela le-Hydroxyl liyi-1 ye-Hydroxyl Imolekyuli ye-HPMC yancitshiswa, eyayibangelwa kukunxibelelanisa ukunxibelelanisa phakathi kwamaqela e-HPMC kunye neqela le-dialdehyde kwi-GLTAROLDE [74]. Ukongeza, kwafunyaniswa ukuba ukongezwa kwe-glutaraldehyde akutshintshanga isikhundla se-HPMC, ebonisa ukuba ukongezwa kwe-GLMCHHYHDE.

4.3.2 Iipatheni ze-XRD ze-GLTHANAREAREHHYHHYHHYHYHHYHHY LEPMC Iifilimu

Ngokwenza umntu we-X-Ray kwimpahla kunye nokuhlalutya ipatheni ye-wansos, yindlela yophando yokufumana ulwazi olunjengolwakhiwo okanye i-morphology yeeatom okanye iimolekyuli ngaphakathi kwezixhobo. Umzobo 4.2 ubonakalisa iipateni ze-XRR DORMS zefilimu ze-HPMC kunye ne-GLTAREAREROLDEHHYHHHYHHHHYHHHYHHHYHHHYHHHY YOBUCHULE. Ngokwanda kwe-glutaraldeodden yongezwa, ubukhulu beencopho ze-HPMC malunga ne-9.5 ° ukuya kwi-20.4.4. Ukunxibelelanisa ukunxibelelanisa kwenzeka phakathi kweqela le-hydroxyl kunye neqela le-hydroxyl kwi-HPMC Molecule, ekwadanisa ukushukumiseka kwe-molecular Chain [75], ngaloo ndlela kunciphisa ilungiselelo lokucwangciswa kwe-HPMC moleccule.

Fig.4.2 I-XRD yeefilimu ze-HPMC phantsi kwe-glutaraldehyde yomxholo

4.3.3 Isiphumo se-glutaraldehyde kwi-Somabing yamanzi yeefilimu ze-HPMC

Fig.3.3 isiphumo se-glutaraldehyde kwi-strabing yamanzi yeefilimu ze-HPMC

Ukusuka kumzobo 4.3 Isiphumo songezelelo lwe-GLTAROLDEHHYHHYHHHYKHHI YENKCUBEKO ZE-HPMC, inokubonwa ukuba ngokunyuka kwe-GLTHANCOLDE DOSS, ixesha lokuzola kwamanzi lweefilimu ze-HPMC lihlala ixesha elide. Ukunxibelelanisa ukunxibelelanisa kwenzeka kwiqela le-Aldehyde kwi-GLTHANAREARDE, kukhokelela ekunciphiseni kwe-HPMCYL kwifilimu ye-HPMC kunye nokunciphisa ifilimu yamanzi yefilimu ye-HPMC.

4.3.4 Isiphumo se-glutaraldehyde kwiiPropathi zoMatshini weefilimu ze-HPMC

Fig.4.4 Isiphumo se-glutaraldehyde kwizinto zamandla e-tensle kunye nokuqhekeza iifilimu ze-HPMC

Ukuze aphande isiphumo se-GLTHANAREARECHEHYDDER KWIPRORTURE YENKCUBEKO ZE-HPMC, amandla e-thansengation kunye ne-Elongile kunye ne-Elonghation kwiFayile eziguqulweyo zavavanywa. Umzekelo, 4.4 yigrafu yesiphumo se-glutaraldehdehyde kwi-sundours amandla kunye ne-Elongretion kwifilimu. Ngokwanda kwe-glutaraldeodde yongezwa, amandla e-sunsengation kunye ne-Elongile kwikhefu leefilimu ze-HPMC zanda kuqala emva koko kuncitshisiwe. Imeko ye. Ukunyuswa komnqamlezo we-glutaraldehde kunye ne-seluplose ye-etherhesition enqamlezileyo, emva kongeza amaqela e-HPMC, amaqela amabini e-HPMC kwi-binds, ukunyusa ubume boomatshini be Iifilimu ze-HPMC. Ngongezwa okuqhubekayo kwe-glutaraldehde, umnqamlezo odibanisa isisombululo kwisisombululo esonyukayo, esibonisa ukuba iimodeli ezihamba zizinto zangaphandle, ezibonisa ukuba iifilimu zoomatshini, ezibonisa ukuba iifilimu ze-HPMC ze-HPMC Ukusuka kumzobo 4.4, isiphumo se-GLTHANAREARDODDDE KWIPOO ZEZICWANGCISO ZE-HPMC sibonisa ukuba xa i-GLMCAREROLDECHEDDE yi-0.25%, ifuthe lokuwela iifilimu ze-HPMC zingcono.

4.3.5 Isiphumo se-GLTHANAREARECHDDDE KWIPROPAIC ZESPMC Iifilimu ze-HPMC

Ukukhanya okukhanyayo kunye ne-haze ziiparamitha ezibaluleke kakhulu zendlela yokusebenza yeefilimu zokupakisha. Owona msebenzi mkhulu, okungcono ukucaca kwefilimu; I-haze, ekwabizwa ngokuba yinkozo, ibonisa inqanaba lokuqina kwefilimu, kunye nokukhulu kwengqolowa, okubi ngakumbi kwifilimu. Umzobo 4.5 Ngaba i-curve yefuthe lezinto ezinokongezwa kwe-glutaraldehyde kwiipropati ze-HPMC. Ingabonwa kumzobo ngokwenza ukongezwa kwe-glutaraldehyde, ukuhambisa ukukhanya kuqala kunyuka kancinci, emva koko kunyuke ngokukhawuleza; I-haze yancipha kuqala yaze yanda. Xa ukongezwa kwe-glutaraldehde yayiyi-0.25%, ukuguqula ifilimu ye-HPMC kufikelele kwixabiso eliphezulu lama-93%, kwaye i-haze ifikelela kwixabiso eliphantsi le-13%. Ngeli xesha, intsebenzo ye-Optical yayingcono. Isizathu sokwanda kweepropathi ezibonakalayo kukunxibelelanisa ukunxibelelanisa phakathi kwe-GLTAROLDEYDE YEMOYAKELWENI NOQEQESHO OLUFUMANELEKILEYO KWI-PREMSCHEECMSUSE FILMS [77-79]. Xa iarhente yokunxibelelanisa inkcitho igqithisile, iindawo ezinqamlezileyo zigqithisile, isihlobo sihamba phakathi kweemolekyuli zenkqubo kunzima ukuza kuthi, kwaye kulula ukuba kwenzeke i-genomen. Ke ngoko, iipropathi zamehlo zeefilimu ze-HPMC ziyancitshiswa [80].

Fig.4.5 Iziphumo ze-glutaraldehyde kwipropathi ye-HPMC yeefilimu ze-HPMC

4.4 Seles

Ngolu hlalutyo lungentla, ezi zigqibo zilandelayo zitsaliwe:

I-1) I-incradrium ye-glutaralde-ifilimu enqamlezileyo ye-HPMC ibonisa ukuba ifilimu ye-glutaraldehyde kunye ne-HPMC ye-HPMP ye-film-cross ross-roction.

2) Kufanelekile ukongeza i-glutaraldehded kuluhlu lwe-0,25% kwi-0.44%. Xa isixa esongengezelwa kwe-GLTHANAREYODDDE yi-0.25%, iipropathi ezibanzi zoomatshini kunye neempawu ezibonakalayo zefilimu ye-HPMC zingcono; Emva kokunxibelelanisa umnqamlezo, ukuvela kwamanzi kwifilimu ye-HPMC iqiniswe ixesha elide kwaye ukuncitshiswa kwamanzi kuncitshisiwe. Xa inani elongeziweyo le-glutaraldehde liyi-0.44%, ixesha lokuluka amanzi lifikelela malunga ne-135min.

ISAHLUKO 5 I-HPMXIONARD ye-AntioXMC ye-HPMC ye-HPMCS enyibilikayo

5.1 Intshayelelo

Ukwenzela ukwandisa ukusetyenziswa kwe-Hydroxypropyl Methylcelgalose ifilimu yokutya, esi sahluko sisebenzisa i-antioxidida ye-antioxidant (i-AOB) njengeyona ndlela inamagqabi e-antioxidants enamagqabi ahlukeneyo. Ifilimu yokufakwa kwamanzi e-Antiyoxidant HPMCDI yokupakisha amanzi, funda iipropathi ze-antioxidant, funda i-Antioculant ye-Antioxidant, i-Stoubimation yamatshini kunye neempawu ezibonakalayo zefilimu, kwaye zibonelela ngesiseko senkqubo yokutya.

5.2 Uvavanyo

5.2.1 Izinto zovavanyo kunye nezixhobo zovavanyo

I-TAB.5.1 Izinto zovavanyo kunye neenkcazo

I-TAB.5.2 Izixhobo zokuvavanywa kunye neenkcazo

5.2.2 Ukulungiswa okutsha

Lungisa i-HydroxyPOpyl Methylcelcelgalose yokupakisha amanzi anyibilikisi kunye ne-Antisoogimel ye-Antisooge ye-Gamboo ye-Godropyl GothylcelUlose yongeza umlinganiso othile (0% 0.03%, I-0.05%, i-0.07%, i-0.09%) ye-bamboo yegqabi ye-antioxidants kwisisombululo sokwenza ifilimu sefilimu, kwaye siyaqhubeka nokuvuselela

Ukudityaniswa ngokupheleleyo, vumela ukuma kubushushu begumbi kangangee-3-5 kwimizuzu emi-5 (i-DeFoFing) ukulungiselela izisombululo zokwakha i-HPMC zefilimu ezinamagqabi ahlukeneyo e-Antisoogidants. Yomisa kwi-oveni eyomileyo, kwaye uyibeke kwi-oveni eyomileyo ukuze isetyenziswe kamva emva kokufaka ifilimu. Ifilimu elungiselelwe i-Hydroxylcelcel Methylcelcelgalose ifilimu yephakheji edityanisiweyo yongezwa nge-biob yegqabi i-antioxidant idluliselwe kwifilimu ye-AOB / ye-HPMC yefutshane.

5.2.3 UQEQESHO NOVAVANYO LWEZOQOQOSHO

5.2.3.1 Uhlalutyo lwe-infraper

I-Incraction Accurmed I-Spectra yeefilimu ze-HPMC zalinganiswa kwimowudi ye-ATR usebenzisa i-NOOLET 5700 Inguqu ye-Inrad Dectrometer eveliswe ngumbutho we-thertoeletric.

5.2.3.2 I-Angle-Angle-Ray's Angles

5.2.3. UKUHLAZIYELWA KWEEMPAWU ZE-Antisoxidant

Ukwenzela ukulinganisa iipropathi ze-antioxidant zefilimu ezilungiselelwe i-HPMC kunye neefilimu ze-AOB / ze-HPMC, indlela ye-DPPH ye-radical ye-radical yasimahla yokulinganisa i-radicals ye-radicals, ukuze ilinganise ngokungathanga ngqo kwifilimu yefilimu.

Ukulungiswa kwesisombululo se-DPHh: Ngaphantsi kweemeko ezinomtsalane, jikisa i-2 mg ye-DPPH kwi-40 ml yesinyibiliki ye-ethanol selvent, kunye ne-anicate kangangemizuzu emi-5 yokwenza iyunifomu yesiqhelo. Ivenkile kwifriji (i-4 ° C) ukuze isetyenziswe kamva.

Ukubhekisa kwiNdlela yoVavanyo ye-Zhong Yuansheng [81], ngokuguqulwa kancinci, umlinganiso wexabiso le-A0: thatha i-2 ml yesisombululo se-DPHH kwixabiso le-DPH, kwaye ulinganise ixabiso (519nm) nge-UV SpectraPhotometer. ngu-A0. Ukulinganiswa kwexabiso: Yongeza i-2 ml yesisombululo se-DPHH kwityhubhu yovavanyo, emva koko yongeza i-1 ml yesisombululo se-HPMC ukuxuba ngokucokisekileyo, thatha amanzi njengolawulo olungenanto kwiqela ngalinye. I-DPPH yasimahla ye-radical ye-radical ye-radical ratical indlela yokubala i-foulation ibhekisa kule foryurula,

Kwifomula: i-absorby yesampulu; I-A0 lulawulo olungenanto

5.2.3 Ukuzimisela kweepropathi zoomatshini: ngokufanayo ne-2.2.3.2

5.2.3.5 Ukuzimisela kweepropathi ezichanekileyo

Iipropathi ze-Optical Izalathisi ezibalulekileyo zokungafihlisi iifilimu zokupakisha, ikakhulu zibandakanya ukuhambisa kunye ne-haze yefilimu. Ukudluliselwa kunye ne-haze yeefilimu kwakulinganiswa kusetyenziswa i-haze tester. Ukukhanya okukhanyayo kunye ne-haze yeefilimu kwalinganiswa kubushushu begumbi (25 ° C kunye ne-50% rh) kwiisampulu zovavanyo ezinendawo ecocekileyo kwaye akukho funga.

5.2.3.6 Ukuzimisela kokungasebenzi kwamanzi

Sika ifilimu engama-30mm ngobukhulu be-45m, yongeza i-100ml yamanzi ukuya kwi-200ml beaker, yibeke ifilimu embindini wamanzi, kwaye ulinganise ixesha kwifilimu ukuba inyamalale ngokupheleleyo. Ukuba ifilimu inamathela eludongeni lwe-beaker, kufuneka ilinganiswe kwakhona, kwaye iziphumo zithathwa njengomyinge wamaxesha ama-3, iyunithi yimiz.

5.2.4 Ukulungiswa kwedatha

Idatha yovavanyo yenziwa nge-Excel kwaye ithwaxwa yisoftware yendalo.

5.3 Iziphumo kunye noHlatho

5.3.1 Uhlalutyo lwe-FT-IR

Umzobo we-HPMC kunye ne-AOB / HPMC

Kwimolekyuli ze-organisele, iathom eyenza i-bonds yekhemikhali okanye amaqela asebenzayo akwimeko yokuhamba rhoqo. Xa iimolekyuli ze-organic zizaliswe kukukhanya kwe-infrared, iibhondi zemichiza okanye amaqela asebenzayo kwiimolekyuli zinokufumana ii-chickos, ukuze ulwazi malunga ne-molecule inokufunyanwa. Umzobo 5.1 Veza i-fir ficra yefilimu ye-HPMC kunye ne-AOB / HPMC. Ukusuka kumzobo 5, kunokubonwa ukuba i-slecal ye-facetal ye-Hydroxypropyl Methylcelcelsulose igxile ikakhulu kwi-2600 ~ 3700 cm-1 kunye ne-750 ~ 100 cm-1. I-chibiction eqinileyo kwingingqi ye-950 ye-CM-1 ye-CM-1 ikakhulu ingummandla we-CO Skeleton wolula inkohliso. Ibhendi yokufumana i-HPMC kufutshane ne-3418 cm-1 ibangelwa kukuntywila kweqela le-OHDROXYL kwiQela le-Hydroxyproxy kwi-1657 cm-1 ye-CM-1 ibangelwa kukungcangcazela kwesakhelo [82]. I-Peipks zokufundwa nge-1454cm-1, 1373cm-1, 1315cm-1 kwaye i-945cm-1 iqhelekile i-asymmetric, i-chibmetrical specings, i-83]. I-HPMC yaguqulwa nge-AOB. Ukongezwa kwe-AOB, isikhundla sencopho nganye ye-AOB / i-HPMC ayitshintshanga, ebonisa ukuba ukongezwa kwe-AOB akuzange kutshabalalise amaqela e-HPMC ngokwawo. Ukusolula ukuntywila kwe-OH ye-OH ye-OH ye-And kwi-Abob ye-AOB / yefilimu kufutshane ne-3418 cm-1 yenzekile, kwaye i-cubing ye-petylene ibangelwa kukungeniswa kwe-hydrogen ye-hydrogen ye-hydrogen. 12], Inokubonwa ukuba ukongezwa kwe-AOB kunefuthe kwi-Intermolecular Bonds.

5.3.2 I-XRD uhlalutyo

Fig.5.2 XRD ye-HPMC kunye ne-AOB /

Fig.5.2 XDR ye-HPMC kunye ne-AOB / HPMC

I-Crystalline ye-Crystalline yeefilimu yahlalutywa ngu-X-ray-ray. Umzobo 5.2 ubonakalisa iipateni ze-XRR DORMS zeefilimu ze-HPMC kunye neefilimu ze-AAOB / HPMC. Ingabonwa kumzobo ukuba ifilimu ye-HPMC ineencopho ezi-2 zokumahlukana (9.5 °, 20.4 °). Ngezongezwa kwe-AOB, iincopho zokumahlukana malunga ne-9.5 ° kunye ne-20.4 ° abuthathaka, zibonisa ukuba iimolekyuli zefilimu ye-AOB / i-HPMC zicwangciswe ngendlela elungelelanisiweyo. Amandla anciphe, ebonisa ukuba ukongezwa kwe-AOB kuphazamise ilungiselelo le-Hydroxylcellity Choin, ichithe amalungiselelo okuqala e-HydroxlyPUlose.

5.3.3 Iipropathi ze-antioxidant

Ukwenzela ukuphonononga isiphumo songezelelo lwe-aob olwahlukileyo kwi-OBIDE YOKWENZIWA KWE-AOB / HPMC, iifilimu ezinezinto ezahlukeneyo ze-AOB (0, i-0, 0.05%, i-0.09%) zaphandwa, ngokwahlukeneyo. Iziphumo zomgangatho wokubhukuqa wesiseko, iziphumo ziboniswa kumzobo 5.3.

Fig.5.3 Isiphumo seefilimu ze-HPMC phantsi komxholo we-AOB kwi-DPPH

Ingabonwa kumzobo 5.3 ukuba ukongezwa kom-Aneb Metioxidant ukuphuculwa kwenqanaba lokulinganisa lwe-DPPH radicals yiifilimu ze-HPMC yi-AITMMC, kunye nokunyuka kwe-AITHICS, i-DCHHICS YOKUGQIBELA YOKUQALA KAKHULU emva koko wanyuka ngokuthe chu. Xa inani elongeziweyo le-AOB liyi-0.03%, ifilimu ye-AOB / i-AOB / i-AOB / i-AOB / i-AOB / i-AOB ifikelela kwi-radicals ye-DPPh ifikelela kwi-Anti -c-Wilimes yeli xesha; Xa umxholo we-AOB wayengu-0.05% kwaye i-0.07%, i-DPPH i-DPHH i-radical scarementing ye-AOB / ifilimu ye-AOB / i-HPMC yayiphezulu kunelo kwiqela le-0.03%; Oku kunokuba ngenxa yokufumana i-antisobxidants egqithisileyo yendalo ekhokelele ekukhokeleni kweemolekyuli ze-aob kunye nokusasazwa okungalinganiyo kwifilimu, oko kuchaphazela iifilimu ze-aneb / hpmc. Ingabonwa ukuba ifilimu ye-AOB / i-HPMC ilungiselelwe i-oxition ine-anti-oxido ochadation. Xa isixa esongezwa yi-0.03%, ukusebenza kwe-oxidation ye-AOB / Ifilimu ye-AOB yeyona inamandla.

5.3.4 Ukuzalwa kwamanzi

Ukusuka kumzobo 5.4, ifuthe le-antioisooginal ye-biob ye-antioubidants ye-Hydroxypropyl Methylcelsel, inokubonwa ukuba ukongezwa kweefilimu ze-AOB ze-HPMC yeefilimu ze-HPMC. Emva kongeza i-AOB, ngokunyuka kwenani le-AOB, ixesha elinamanzi lefilimu lalilifutshane, elibonisa ukuba ifilimu yamanzi ye-AOB / HPMC yayingcono. Oko kukuthi, ukongezwa kwe-AOB kuphucula ukwahlula i-aob / hpmc amanzi kwifilimu. Ukususela kuhlalutyo lwangaphambili lwe-XRD, lunokubonwa ukuba emva kokongeza i-AOB, i-crystallies yefilimu ye-AOB / ye-HPMC incitshisiwe, ifilimu ye-AOB / ye-AOB / i-AOB / HPMC iphuculwe kwinqanaba elithile. Ukungathobeli kwamanzi kwifilimu.

Umzobo

5.3.5 Iipropathi zoomatshini

Umzobo

Ukusetyenziswa kwezixhobo ezinqabileyo zefilimu kuninzi kakhulu, kwaye iipropathi zayo zoomatshini zinempembelelo enkulu ekuziphethemeni kwenkonzo yeenkqubo ezisekwe kwi-membrane ezisekwe kwi-shots. Umzobo 5.5 bonisa amandla e-thensengation kunye ne-elongwation kwi-curves ye-AOB / HPMC yeefilimu. Ingabonwa kumzobo ukuba ukongezwa kwe-aob ezahlukeneyo kuneziphumo ezibalulekileyo kwiipropathi zoomatshini beefilimu. Emva kongeza i-AOB, ngokunyuka kwe-AOB engezelelo, i-AOB / HPMC. Amandla e-sunsen kwifilimu abonisa indlela esezantsi, ngelixa i-elongince kwikhefu ibonisa imeko yokuqala eyandayo kwaye incipha. Xa umxholo we-AOB wayengu-0.01%, i-elongiya kwifilimu ifikelele kwixabiso eliphezulu lama-45%. Iziphumo ze-AOB kwiipropathi zoomatshini beefilimu ze-HPMC ziyabonakala. Ukusuka kuhlalutyo lwe-XRR, lunokubonwa longezelelo lwe-Aneb ye-Aneb inciphise i-crystallies ye-aob / ifilimu ye-AOB / ye-HPMC, iya kunciphisa amandla e-aob / ifilimu ye-AOB / HPMC. I-Elongition ekhefu kwiqhekeza kuqala inyukele kwaye incipha, kuba i-AOB inomhlaba olungileyo kunye nokuhambelana, kwaye yinto encinci yemolekyuli. Ngexesha lenkqubo yokungqinelana ne-HPMC, amandla onxibelelwano phakathi kweemolekyuli zenziwe buthathaka kwaye ifilimu ithanjisiwe. Isakhiwo esingqongqo senza i-AOB / Ifilimu ye-AOB ithambile kwaye i-Elongition kwikhefu lokunyuka kwefilimu; Njengoko i-AOB iqhubeka ikhula, i-elongition kwikhefu le-AOB / HPMC iyancipha, kuba ifilimu ye-AOB yenze i-macromoleks, kwaye ifilimu ilula ukuba icinezeleke xa ifilimu icinezelekile Ifilimu ye-AOB / HPMC iyancipha.

5.3.6 Iipropathi ze-Optical

Fig.5.6 Isiphumo se-AOB kwipropathi ye-HPMC yeefilimu ze-HPMC

Umzobo 5.6 Igrafu ebonisa utshintsho kwi-distemittance kunye ne-haze yeefilimu ze-AOB / HPMC. Ingabonwa kumzobo ngokuphunyezwa kwenani le-AOB eyongeziweyo, ukuhanjiswa kwefilimu ye-AOB / HPMC kuyancipha nokunyuka kwe-haze. Xa umxholo we-AOB akazange adlule kwi-0.05%, amaxabiso okutshintsha okukhanyayo kunye ne-haze yeefilimu ze-AOB / HPMC azicotha; Xa umxholo we-AOB ugqithile kwi-0.05%, amaxabiso okutshintsha okukhanyayo kunye ne-haze zakhawulezisa. Ke ngoko, isixa se-AOB esongeziweyo akufuneki sidlule kwi-0.05%.

5.4 amacandelo alo sahluko

Ukuthatha i-antiof ye-antioxidant (i-AOB) njenge-Antioxidant yendalo kunye ne-Hydroxylcelcel Methylcelculose Ifilimu ye-AOB / i-HPMC ye-All -c yephakheji elungiselelwe lo msebenzi unemisebenzi esebenzayo yokulwa i-anti-oxidation. Ifilimu ye-AOB / i-HPMC ene-0.03% aob inereyithi yokuthambisa malunga ne-89% ye-DPPH SHICS, kunye nokusebenza kakuhle kweyona nto ngaphandle kwe-AOB. Ifilimu ye-HPMC nge-61% iphuculwe. Ukuzenzela amanzi ukonakala kukuphuculwa kakhulu, kwaye iipropathi zoomatshini kunye neepropathi ezibonakalayo zinciphile. Ukuxhathisa i-oxidation efunyenweyo ye-AOB / yeFPMC yeFilimu yandise isicelo sayo kwiphakeji yokutya.

ISAHLUKO VI ISIQINISEKISO

1) Ukunyuka kwe-HPMC yeFowuni yeFowuni yeFowuni, iipropathi zoomatshini wefilimu yanda yaza emva koko inciphile. Xa i-HPMC yefilimu yefilimu yayiyi-5%, iipropathi zoomatshini wefilimu ye-HPMC yayingcono, kwaye amandla anobuqili yayingu-116MPA. I-Elongition kwikhefu malunga ne-31%; Iipropathi zamehlo kunye nokuluka kwamanzi kuncipha.

2) Ukonyuka kweqondo lokushisa lefilimu, iipropathi zoomatshini beefilimu zefilimu zaza zanda zaza zancitshiswa, ziye zancipha, ukonakala kwamajoliso kuphuculwe, kwaye ukuncipha kwamanzi kunciphe. Xa iqondo lobushushu lefilimu lingama-50 ° C, intsebenzo iyonke ibhetele, amandla anencasa imalunga ne-116MPA, ukuhambisa ixesha malunga ne-55min, ke iqondo lokuchitha lamanzi lifanelekile kwi-50 ° C.

3) Ukusebenzisa iiplastiki zokuphucula ubunzima beefilimu ze-HPMC, ngokongezwa kwe-glycerol, i-elongiya kwikhefu leefilimu ze-HPMC zonyuke kakhulu, ngelixa amandla e-nunsile ehla. Xa inani le-glycerol eyongeziweyo laliphakathi kwe-0.15% kunye ne-0.25%, i-elongiya kwifilimu ye-HPMC yayimalunga ne-50% yamandla e-thenpa.

4) Ukongezwa kwe-shorbil, i-elongiya kwikhefu lefilimu inyuka kuqala emva koko inciphe. Xa ukongezwa kwe-sorbibil imalunga ne-0.15%, i-elongition kwikhefu ifikelela kwi-45% kunye namandla amanye amazwe malunga ne-55MPA.

5) Ukongezwa kwamaprimbi amabini, i-glycerol kunye ne-shorbil, zombini zancipha iipropathi zonyango kunye nokubethwa kwamanzi kweefilimu ze-HPMC, kunye nokwehla akulunganga. Ukuthelekisa isiphumo seplastikisi seplasitiki kwiifilimu ze-HPMC, inokubonwa ukuba isiphumo seplalycerol silunge ngakumbi kuneso se-sorbimol.

I-6) ngokusebenzisa i-spectroscopy (fir) kunye nohlalutyo lwe-X-ray-ray ye-X-ray-ray-ray, ukunxibelelanisa umnqamlezo we-glutaraldehyde kunye ne-HPMC kunye ne-crystallity emva kokunxibelelanisa umnqamlezo emva kokuba ifundwe. Ngezongezwa kwe-arhente yokudibanisa i-glutaralde, amandla e-thanch kunye ne-Elongile kwikhefu lezifilimo ezilungiselelwe i-HPMC kuqala kwaye inciphe. Xa ukongezwa kwe-glutaraldehdede yi-0.25%, iipropathi ezibanzi zoomatshini beefilimu ze-HPMC zingcono; Emva kokunxibelelanisa umnqamlezo, ixesha lokulinganisa amanzi lihleli ixesha elide, kwaye ulwelo lwamanzi luyancipha. Xa ukongezwa kwe-glutaraldehyde yi-0.44%, ixesha lokulinganisa amanzi lifikelela malunga ne-135min.

7) Ukongeza isixa esifanelekileyo se-AOBOB yendalo kwisisombululo sefilimu ye-HPMC, ifilimu elungiselelwe amanzi e-AOB / HPMC ye-AOB / HPMC ye-AOB ye-AOB ineempawu ezisebenzayo zokuchasa. Ifilimu ye-AOB / HPMC ene-0.03% ye-AOB iyongezwe i-0.03% AOB ukuya kwi-DAPHICS Free Ricals imalunga ne-89% yexabiso lefilimu ye-HPMC ngaphandle kwe-AOB ngaphandle kwe-AOB ngaphandle kwe-AOB ngaphandle kwe-AOB ngaphandle kwe-AOB ngaphandle kwe-AOB ngaphandle kwe-AOB ngaphandle kwe-AOB ngaphandle kwe-AOB ngaphandle kwe-AOB ngaphandle kwe-AOB ngaphandle kwe-AOB ngaphandle kwe-AOB ngaphandle kwe-AOB ngaphandle kwe-AOB ngaphandle kwe-AOB ngaphandle kwe-AOB ngaphandle kwe-AOB. Ukuzenzela amanzi ukonakala kukuphuculwa kakhulu, kwaye iipropathi zoomatshini kunye neepropathi ezibonakalayo zinciphile. Xa isixa esongezelelekileyo se-0.03% AOB, isiphumo sokuchasana nefilimu silungile, kwaye ukuphuculwa kwenkqubo yokulwa i-AOB / ye-HPMC yandisa ukusetyenziswa kwale fashati yokufakwa kwephakheji.