1. Iipropathi ezisisiseko ze-HPMC
I-Hypromellose, igama lesiNgesi i-Hydroxypropyl Methylcelcelose, alias hpmc. Ifomula yayo ye-moleula i-c8h15o8- (c1oh8o6) I-N-C8HL5O8, kwaye inxenye ye-methyl kunye nenxalenye ye-puzydl kunye nenxalenye ye-polyhyl ye-pollydroppropy ye-polyulose. Ingaveliswa ngeendlela ezimbini: Enye yeyokuba inqanaba elifanelekileyo le-methyl seluplose liphathwa ngoNah, emva koko lasalelwa nge-propylene oxide phantsi kobushushu obuphakamileyo kunye noxinzelelo. Ifom iqhagamshelwe kwi-anhhydrogluplucose ye-sellyuolose, kwaye inokufikelela kwinqanaba elifanelekileyo; the other is to treat cotton linter or wood pulp fiber with caustic soda, and react with methyl chloride and propylene oxide successively to obtain it, and then further refine , crushed to make fine and uniform powder or granules. I-HPMC yintlobo zeselfowuni yeNdalo, kwaye ikwangowona mbono ubalaseleyo wamandla, onoluhlu olubanzi lwemithombo. Okwangoku, isetyenziswa ngokubanzi ekhaya nakwamanye amazwe, kwaye yenye yezona zineziso zeyeza zokusetyenziswa kwezemigangatho ephezulu kumachiza ezenzo.
Le mveliso imhlophe ukuba i-milny imhlophe ngombala, ongenatyhefu kwaye ayinambulelo, kwaye ikwimo yomgubo wegranuule okanye i-fibrous ehamba ngokulula. Ihlala phantsi kokuvezwa kokukhanya kunye nokufuma. I-sloble emanzini ebandayo ukwenza isisombululo esimhlophe se-Colloidal, esinenqanaba elithile le-viscofity, kwaye i-viomenon ye-SOLO-GOLKNION inokwenzeka ngenxa yokutshintsha kobushushu bendlela yokutshintsha kwesisombululo. Inyibilika kakhulu kwi-70% yotywala okanye i-dimthyl ye-himthyl ye-himthyl, kwaye ayiyi kunyibilika kutywala ngokupheleleyo, i-chloroform okanye ethoxyene.
Xa i-PH ye-hypromellose iphakathi kwe-4.0 ne-8.0, inozinzo olulungileyo, kwaye lunokubakho ngokuthobeka xa i-PH iphakathi kwe-3.0 ne-11. Xa iqondo lobushushu lingama-20 ° C kunye nomswakama onesizalwane ngama-80%, igcinwe iintsuku ezili-10. I-Action yokufumanisa i-monssody ye-HPMC yi-6.2%.
Ngenxa yoqulatho olwahlukileyo lwe-Mayipsy kunye ne-hydroxypropyl kwisakhiwo se-hypromellose, iintlobo ezahlukeneyo zeemveliso zivele. Kwingcinezelo ethile, iindidi ezahlukeneyo zeemveliso zinee-viscofity ezikhethekileyo kunye namaqondo obushushu omhlaba oqubisa, ke, aneempawu ezahlukeneyo kwaye unokusetyenziselwa iinjongo ezahlukeneyo. I-pharmacopoeiaias yamazwe awahlukeneyo inemigaqo kunye nezimvo ezahlukileyo kwimodeli: ngokokufakwa kwi-pharmacovia eyahlukileyo kunye namabakala eemveliso ezithengiswayo kwintengiso, kwaye iyunithi nguMparo; E-United States pharmacoopoeeia, igama eliqhelekileyo longeza amanani ama-4 ekugqibeleni ukubonisa umxholo kunye nohlobo lwe-Hypromellose i-2208, amanani amabini okuqala amele ipesenti ye-hydroxypropy ye-hydroxypropy yepesenti.
2. Indlela yokuphelisa i-HPMC emanzini
2.1 indlela eshushu yamanzi
Kuba i-hypromellose ayinyibili amanzi ashushu, inokuba isasazeke ngendlela efanayo emanzini ashushu ekuqaleni, kwaye ipholile. Iindlela ezimbini eziqhelekileyo zichazwe ngolu hlobo lulandelayo:
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2.2 Indlela yokuxuba yomgubo
Amasuntswana epowulayo asasazeke ngokupheleleyo ngokuxuba owomileyo ngenani elilinganayo okanye elikhulu kwezinye izithako zepowdery, kwaye emva koko inyibilikiswe emanzini. Ngeli xesha, i-hypromellose inokuchithwa ngaphandle kwe-algimeration.
3. Izibonelelo ze-HPMC
3.1 Ukuzenzela amanzi okubandayo
Inyibilikiswa emanzini abandayo apha ngezantsi kwe-40 ° C okanye i-70 i-ethanol, ngokusisiseko i-ensanol emanzini ashushu ngaphezulu kwe-60 ° C, kodwa inokugungqa.
3.2 Ukungazi
I-Hypromellose (i-HPMC) luhlobo lwe-ionic seluplose ether. Isisombululo sayo asinayo i-ionic call kwaye ayisebenzi ngeetyuwa zensimbi okanye i-ionic yendalo. Ke ngoko, ezinye izinto ziyasebenza azisabeli ngayo ngexesha lenkqubo yokulungiselela.
3.3 Uzinzo
Ihlala izinzile kwi-acid kunye ne-alkali, kwaye inokugcinwa ixesha elide phakathi kwe-PH 3 kunye ne-1L ngaphandle kokutshintsha ngokucacileyo kwi-vickosity. Isisombululo se-accoellose ye-hypromellose (i-HPMC) inefuthe ye-anti-merdew kwaye inokugcina uzinzo lolwazi oluhle ngexesha lokugcina ixesha elide. Amayeza e-HEMACSS esebenzisa i-HPMC njengoko izihlobo zinozinzo olusemgangathweni kuneendlela ezisebenzisa izihlobo zesintu (ezinje nge-dextrin, isitatshi, njl njl.).
3.4 Utshintsho lwe-viscosity
I-Viscotives eyahlukileyo ye-HPMC inokuxubungulwa ngokwemilinganiselo eyahlukeneyo, kwaye uVecofity wayo unokutshintsha ngokwemigaqo ethile, kwaye unobudlelwane obulungileyo obulungileyo, ke umyinge unokukhethwa ngokweemfuno.
3.5 I-Metabolic Intia
I-HPMC ayifunxanga okanye ibekwe emzimbeni, kwaye ayiboneleli ngobushushu, ngoko yindawo yokulungiselela amayeza akhuselekileyo.
3.6 Ukhuseleko
Kuyikholelwa ngokubanzi ukuba i-HPMC yinto engenatyhefu kunye nokungakhathali. Idosi ye-menage ye-metal yempuku ye mig i-5G / kg, kunye nedosi ye-metal ye-metal ye-rats ye-RTS i-5.2G / kg. Iidosi zemihla ngemihla azinabungozi ebantwini.
I-4. Ukusetyenziswa kwe-HPMC ngokulungiselela
4.1 Njengoko ifilimu yokuhamba kwefilimu kunye nezinto ezenza ifilimu
Usebenzisa i-hypromellose (i-HPMC) njengemixholo yecwecwe lefilimu, xa kuthelekiswa neetafile zemveli ezinamaphepha, iitafile ezihlanganisiweyo azinazinzuzo ezibonakalayo ekufumaneni incasa yokuncancisa i-TOORK NOBUCHULE, UKUTHENGA OKANYE UKUQHUTYWA KOKUFUNDA KUNYE NOKUFUNDA NGOKUGQIBELA, Ibakala lokufumana le mveliso lisetyenziswa njengempahla yokuhamba ifilimu yamanzi kwiitafile kunye neepilisi, kunye neBanga le-vickosity eliphezulu lisetyenziswa njengezixhobo zokuhamba ngefilimu kwiinkqubo zeShocic. Uxinzelelo luhlala luyi-2.0% ukuya kwi-20%.
4.2 Njengo-Binder kwaye i-suintebgraph
Ibakala lokufumana le mveliso linokusetyenziswa njengendawo yokubhabha kwaye ihlambuluki kwiitafile, iipilisi, kunye ne-grantis, kunye nenqanaba le-viscosity ephezulu linokusetyenziswa kuphela njenge-binder. Umthamo uyahluka ngeemodeli ezahlukeneyo kunye neemfuno. Ngokubanzi, umthamo we-binder yeetafile zegranungs ezomileyo yi-5%, kunye nethamo ye-binder yeetafile zegrama ezimanzi yi-2%.
4.3 Njengearhente yokumiselwa
Iarhente yokumisa i-viscous ye-viscous ye-viscous ene-hydrophility, enokucothisa isantya se-sedition samasuntswana xa isetyenziswa kwi-Arhente yokuNikelwa, kwaye inokuqhotyoshelwa kumphezulu wamasuntswana okuthintela amasuntswana ukusuka kwibhola kunye nokuncipha kwebhola. Iiarhente zokulinganisa zidlala indima ebalulekileyo ekwenzeni ukumiswa. I-HPMC ngohlobo olufanelekileyo lweearhente ezichithayo, kunye nesisombululo se-colloidal esichithiweyo sinokunciphisa uxinzelelo lwe-interface ye-frocial kunye namandla asimahla kumanqanaba amancinci aqinileyo, ngaloo ndlela aphucule uzinzo lwenkqubo yokusasazeka. Inqanaba le-viscosity lemveliso yale mveliso isetyenziswa njengendawo yokulungiswa-yohlobo lwamanzi alungiswa njengearhente yokumisa. Inesiphumo esihle sokumiswa, kulula ukuhlengahlengisa, ayinamathele eludongeni, kwaye inamasuntswana aqhotyoshelweyo. Idosi eqhelekileyo yi-0.5% ukuya kwi-1.5%.
4.4 Njenge-blocker, iarhente yokukhutshwa-khupha i-pore-ebangela iarhente
Inqanaba le-viscosity eliphezulu le mveliso isetyenziselwa ukulungiselela iitafile ze-hydrophilic ze-hytrix ye-gest, iibhloko kunye neearhente zokukhutshwa ezilawulayo ze-matrix, kwaye inefuthe lokulibazisa ukukhutshwa ngamachiza. Ukusetyenziswa kwayo kukusetyenziswa yi-10% ~ 80% (W / W). Amabakala o-viscosity asetyenziswa njengearhente ezenza ukuba ukukhululwa okuzinzileyo okanye amalungiselelo okukhutshwa kwemali. Idosi yokuqala efunekayo kwifuthe lonyango lolu hlobo lwecwecwe linokufezekiswa ngokukhawuleza, emva koko lenze ukukhululwa okuzinzileyo okanye ukulawulwa kokukhululwa, kunye nokugxininiswa kwezaphulelo kwegazi kugcinwe emzimbeni. Xa i-hypromellose idibana namanzi, i-Hydrates yenza ukuba ibe ngumphathi wegel. Indlela yokukhululwa kweziyobisi kwithebhulethi yeMatrix ikakhulu ibandakanya ukwahluka kwe-gel kunye nokukhukuliseka kwegel.
4.5 Ukukhusela iglue njenge-thickener kunye ne-colloid
Xa le mveliso isetyenziswa njenge-thi cokener, uxinzelelo oluqhelekileyo lusetyenziswa yi-0.45% ~ 1.0%. Le mveliso inokwandisa uzinzo lwe-hydrophobic glue, yenza i-colloid ekhuselweyo, nqanda amasuntswana ukusuka kwi-ageglomerads kunye ne-ageglomeleration, malunga nokuxinana kwayo yi-0.5% 1.5% ~ 1.5%.
4.6 I-CAPSULE STOP YECAPS
Ngokwesiqhelo i-capsule ye-capsule ye-capsule ye-capsule isekwe kwiGelatin. Inkqubo yemveliso ye-gelatin ye-getini ilula, kodwa zikho iingxaki kunye ne-phenomena njengokhuselo olubi kwi-subriure kunye nexabiso elinobuthathaka le-oxnygen, kunye nokulibaziseka kwe-chiegue tholl ye-capsule ngexesha lokugcina. Ke ngoko, i-hypromellose, njenge-capsule ye-gelatin, isetyenziswa kumalungiselelo eecapsules, eziphucula ukwenziwa kweecaphus, kwaye zikhuthazwe kakhulu ekhaya nakwamanye amazwe.
4.7 Njengoko bhadisave
Itekhnoloji yebhayiloji, ukusetyenziswa kweziko eline-polymers ye-biolove, ngokusebenzisa i-adhession kwi-molly ye-biolos, kuphucula ukuqhubeka kunye ne-MUCOSA, ukwenzela ukuba ichiza likhululwe kwaye lithathe i-MUCOSA ukuze ifezekise iinjongo zonyango. Okwangoku isetyenziselwa isetyenziselwa ukunyanga izifo ze-Nasal cavity, i-MUCOSA yomlomo kunye namanye amalungu. Itekhnoloji ye-gustrointentinion ye-biadisestion yinkqubo entsha yokuhanjiswa kweziyobisi ephuhliswe kule minyaka idlulileyo. Ayisondisi kuphela ixesha lokuhlala lilungiselela iphecana le-gestrointenal, kodwa liphucula i-membrane yeseli, yokutshintsha ukungena kwechiza ukuya kwi-bimone, ngaloo ndlela iphucule i-biaaais ye-bioas.
4.8 Njenge-gel ye-ntloko
Njengokulungiselela ukunamathela kulusu, ijeli inoluhlu lweenzuzo ezifana nokhuseleko, ubuhle, ukucoca ngokulula, indleko eziphantsi, kunye nokuhambelana neziyobisi. umkhombandlela.
Ixesha leposi: NgoFebwe-14 ukuya ku-525