Hydroxypropyl methylcelcelculose (hpmc) amachaphaza: Ubume kunye neepropathi

I-HydroxyPOpyl Methylcelcelsulose (HPMC) Ii-adhesves zifumene uqwalaselo olubanzi kwimizi-mveliso eyahlukeneyo ngenxa yokungaguqukiyo kunye nobuhlobo bokusingqongileyo. Eli nqaku linika umbono obanzi wokuqulunqwa kunye neepropathi ze-HPMC. Isakhiwo seemolekyuli ze-HPMC, inkqubo yazo yemveliso, kunye nezinto ezichaphazela iipropathi ezinamathela kuzo zixoxwa. Ukongeza, ihlola iipropathi zobumbeko lwe-HPMC kwizicelo ezahlukeneyo nakwizibonelelo zayo zokubulala.

I-HydroxyPOpyTelmethylcelcelcelcelcelcelcelcelcelcelcelcebalose (i-HPMC) i-selsulose ikhutshelwe ngokubanzi kumashishini ahlukeneyo, kubandakanya amayeza, ukutya, ukwakhiwa kunye nemikhono. I-HPMC Deheshees ifumana ukuthandwa njengendlela enobuhlobo kwindalo kubambeko ngokwesiko ngenxa yendalo yabo ye-biedegraya enokubekwa kwindalo kunye nendalo ebalaseleyo.

1.Ubume kunye nemo yemolekyuli ye-HPMC:
I-HPMC ihambelane ukusuka kwi-sellulose, i-polysaccharide ifumene kwiindonga zeseli ezityalo. Utshintsho lwekhemikhali lwe-seluplose ibandakanya ukwenziwa kwamaqela e-hydroxyl nge-propylene oxide kunye ne-methyred nge-methyl chloride ukwenza amaqela e-hydroxyl kunye ne-mayipyy ngokwahlukeneyo. Inqanaba lokufakwa endaweni (DS) ye-hydroxypropy kunye namaqela e-AFGISY inokwahluka, ikhokelela kumabakala ahlukeneyo e-HPMC enepropathi eyahlukeneyo.

Isakhiwo se-phudm se-HPMC siqukethe imixokelelwane ye-Glucose yeyunithi edityaniswe ngu β (1 → 4) Glycosidic. Ubukho be-hydroxypropy kunye ne-Foodsxy ye-Foodsxy kwi-Cleulose Chain inika isoba emanzini kwaye iphucule iipropathi zokwenza ifilimu. Iphethini yokufaka endaweni yokufaka ifuthe kwi-vickosity, isolity, kunye nokuziphatha kwejeli ye-HPMC kwaye ke kukufaneleka kwezicelo zokuncamathela.

I-2.HPMP yokungena kwimveliso yemveliso:
Iincwadana ze-HPMC zihlala zilungiselelwe ngokusasaza i-HPMC PODER emanzini okanye isolvent ukwenza isisombululo se-viscous. Inkqubo yokusasazeka ibandakanya ukuntywila kwamasuntswana e-HPMC, okukhokelela ekumiselweni kokumiswa kwe-colloidal. Uhlobo lwesisombululo se-Binder unokuhlengahlengiswa ngokulawula uxinzelelo kunye nenqanaba lokufakwa endaweni ye-HPMC.

Ngamanye amaxesha, iiplasitizeli ezinje nge-glycerol okanye i-shorbil yongezwa ekuphuculeni ukuguquka kunye namandla ebhondi. Ii-arhente zokunxibelelanisa ezinqamlezileyo ezinje nge-borax okanye iityuwa zentsimbi zinokusetyenziselwa ukomeleza amandla ahlanganisiweyo ee-HPMC. Ifomu elinamathelayo linokuqhubekiswa ngokwezifiso ngokwenza ukongeza izongezo ezinjengee-tackisiers, i-suckecants okanye i-thickedies okanye i-thickeners zokukhuthaza iipropathi ezithile.

I-3. Izinto ezichaphazela ukusebenza okunamathela:
Ipropathi yobumbelela ye-HPMC ichatshazelwa zizinto ezininzi, kubandakanya ubunzima bemolekyuli, isidanga sokufaka, uxinzelelo, i-PH, iimeko zobushushu. Ubunzima obuphezulu bemolekyuli kunye nesidanga sokufakwa endaweni yesiqhelo sisiphumo sokunyuswa kwe-viscofity enyukayo kunye namandla ebhondi. Nangona kunjalo, ukwahlula okugqithisileyo kunokukhokelela kumda okanye ukwahlukaniswa kwesigaba, okuchaphazela iipropathi zokunamathela.

Ukuxinezeleka kwe-HPMC ekuqulunqweni kokunamathela kuchaphazela i-viscofity, ukunamathela kunye nexesha elomileyo. I-PH kunye neqondo lobushushu lichaphazela ukulimala kunye nokuziphatha kwejeli ye-HPMC, ngeeMeko ezifanelekileyo ngokuxhomekeka kwibakala elithile kunye neemfuno zesicelo. Ukunyanga iimeko, njengamaxesha owomileyo kunye neqondo lokushisa, kunokuchaphazela uphuhliso lwe-adhesion kunye nokuqulunqwa kwefilimu.

I-4. Iipropathi ze-adhession ze-HPMC:
I-HPMCheves Abedhessives ibonakalisa iipropathi ezibalaseleyo ezibonisa iindawo ezahlukeneyo, kubandakanywa iphepha, iinkuni, ii-ceramics kunye neplastiki. I-odhes ezinamathela ukuba zenze iqhina eliguquguqukayo nelingayo elinokuxhathisa ngokulungileyo komswakama, ubushushu kunye nokwaluphala. I-HPMC Deheseves ikwane-odor ephantsi, engenatyhefu, kwaye iyahambelana nezinye izongezelelo.

Kwiphepha kunye nezicelo zokupakisha, amadlala e-HPMC asetyenziselwa iilebheli, ukutywina kwebhokisi ye-carton kunye nezaliseka ngenxa yokufika kwabo kuqala kunye namandla abo. Kwicandelo lezokwakha, iindawo ze-HIle ezisekwe kwi-HPMC, isiza sokufaza i-Plasters kunye neenqobo ezidibeneyo zibonelela ngokusebenza kakuhle, iipropathi zokugcina amanzi. Kwindlela yokushicilela, i-HPMC isetyenziselwa ukulawula i-viscofity kunye nokuphucula ukucaciswa.

I-5. Izibonelelo ze-HPMC Dhesive:
Ababukeli be-HPMC banika izibonelelo ezininzi kubabukeli bemveli, besenza ukhetho lokuqala kwizicelo ezininzi. Okokuqala, i-HPMC isuselwa kwimithombo yolwazi ehlaziyiweyo kwaye inokwenzeka yi-biodegrades, inciphisa ifuthe layo kwindalo esingqongileyo. Okwesibini, amaphiko e-HPMC anetyhefu esezantsi kwaye anokubakho, abenze bakhuseleke kwipakethe yokutya kunye nezicelo zonyango.

I-HPMC Dheshees ifuna ukulungiselela umphezulu womphezulu kwaye ibonelele ngokunamathela ngokugqwesileyo kwiindidi ezinobunkunkqele, kuquka izinto ezinamachaphaza. Zinganyangeki kakhulu emanzini, iikhemikhali kunye ne-radiation ye-UV, iqinisekisa ukuqina kwexesha elide kunye nokusebenza. Ukongeza, iincwadana ze-HPMC zinokubekwa ukuba zihambelane neemfuno ezithile ezinjengokunyanga ngokukhawuleza, ukuxhaswa kobushushu obuphezulu okanye ukukhutshwa kwe-voc.

I-6. Ithemba lexesha elizayo kunye nenkqubela phambili:
Imfuno ekhulayo yeemveliso ezizinzileyo nezisingqongileyo iqhuba uphando kunye neenzame zophuhliso zokuphucula ukusebenza kunye nokungaguquguquki kwezilwanyana ze-HPMC. Inkqubela phambili yexesha elizayo inokugxila ekuphuculeni ukumelana kwamanzi, uzinzo lobushushu, kunye nokunamathela kwifomu ye-HPMC ngokusebenzisa ii-Inoveli zoomatshini, iindlela zokunxibelelanisa ezinqamlezileyo, kunye neendlela zokulungisa.

Ukuphuhliswa kweendlela ezizezinye ze-biiodera esekwe kwi-bio kunye ne-biodegrady kwi-polymers zokwenziwa kulindeleke ukuba zandise umda wesicelo se-HPMC kumashishini ahlukeneyo. Ukusebenzisana phakathi kwe-Agusia, ishishini, kunye neearhente zikarhulumente kubalulekile ekuqhubeni itekhnoloji ye-HPMC kunye nokujongana nemiceli mngeni evelayo efana nokuphinda isebenze kunye nolawulo lwenkunkuma.

I-Hydroxypropyl Methylcelceltulose (HPMC) Ukubonelela ngezisombululo ezizinzileyo nezinguqu eziguquguqukayo kwizicelo ezahlukeneyo, ukusuka kwiphepha kunye nokupakisha kulwakhiwo. Ukuqonda ubume kunye neepropathi ze-HPMC kubalulekile ekuqulunqeni izibini ngentsebenzo efanelekileyo kunye nokubekwa kwendalo. Ngokuqhubeka kophando kunye nezinto ezintsha, iincwadana ezinemidlalo, i-HPMC ziya kudlala indima ebalulekileyo ekufezekiseni iimfuno zokutshintsha kweshishini zanamhlanje ngelixa zinciphisa ifuthe kwindalo.