I-HPMC Polymers esetyenziselwa ukwenza iinkqubo ze-hydrophilic ze-hydrophilic ziyafumaneka kumabakala ahlukeneyo okufakwa

I-HydroxypropyTelmethylcelcelcelcelceli (i-HPMC) i-polymer esekwe ngokubanzi kwintsimi yamayeza, ngakumbi ekuphuhlisweni kweenkqubo ze-hydrophilic ze-hydrophilic. Ezi nkqubo ze-matrix zibalulekile ekulawuleni ukukhutshwa kwezithako ezisebenzayo (APIS) kwindawo elawulwayo kwaye ineenzondo. I-HPMC iyafumaneka kumabakala ee-viscosity, ukuvumela iifomula zamayeza ukulungisa iipropathi zenkqubo ye-matrix kwiimfuno ezithile zokukhutshwa kweziyobisi.

1. Intshayelelo kwi-HPMC Polymer

Ingcaciso kunye nesakhiwo
I-HPMC yi-semi ye-semi-synthetic pollemer ethathwe kwi-seluplose. Ine-2-hydroxlypropyl kunye neeyunithi zokuphindaphinda i-methyl eziqhotyoshelwe kwi-Selebose Probone. Iqondo lokufakwa kwezi qela lichaphazela iipropathi ze-HPMC, kubandakanya ukuzolula kwayo, i-viscosity, kunye nobuchule begrisi.

2. Indima kumalungiselelo amachiza

I-HPMC inezibonelelo ezininzi njengengathandekiyo kwifomu yamayeza. Indalo yayo ye-hydrophilic yenza ukuba ilungele ukusetyenziswa kweenkqubo ze-hydrophilic matrix, zenza isakhiwo esifana nejeli xa sinxibelelana namanzi. Olu lwakhiwo lulawula ukukhutshwa kwechiza, ukubonelela ngeziphumo ezinzileyo kunye nexesha elide.

I-3. Utshintsho kwiBanga le-Viscosity

Ukubaluleka kwe-viscofity
I-Viscosity yiparameter ebalulekileyo kwindawo yamayeza esebenzisa i-HPMC. Igqiba iimpawu zokuhamba, ukulungiselela ukulungisa, nokukhupha iimpawu zechiza kwinkqubo ye-matrix. Amabakala ahlukeneyo e-HPMC afumene iikhompyuter ezahlukeneyo, kwaye iifomulators zinokubangela ukuba zenze kakuhle ezi mpahla zisekwe kwiimfuno ezithile zeziyobisi kunye neprofayili yokukhupha okufunwayo.

Ukukhetha iBakala Lokuchola Ibakala
Ukukhetha iBakala lokuVala kwe-HPMC kuxhomekeke kwizinto ezinje ngomhlaba onje, ireyithi yokukhutshwa kwechiza, ifom yedosi kunye nenkqubo yokwenza. Amabakala o-Viscosity Ezantsi angalungela ukukhutshwa kweziyobisi ngokukhawuleza, ngelixa amabakala e-Viscosity ebonelela ngokukhululwa okuzinzileyo.

Ukuguqulwa kwakhona
Ukufumaneka koluhlu lwamabakala ee-viscofity kuphucula ukwenziwa kukaFomulators kwi-PARMUCOD yeefomu zethamo. Oku bhetyebhetye kubalulekile ukulungiselela iipropathi ezahlukeneyo zeziyobisi kwaye uqhubeke nokusebenza kakuhle kwemveliso yokugqibela.

4. Impembelelo kwi-curve yokukhutshwa ngamachiza

Ukukhutshwa kweziyobisi
Iinkqubo ze-HPMC Matrix isebenza kumgaqo-nkqubo we-hydration kunye nokwenziwa kwegel. Xa i-matrix iza kudibana namanzi, iyayihla i-fallmer yegesi ejikeleze amasuntswana enzala. Ichiza likhutshwa ngokuhlukunyezwa kunye nokukhukuliseka kwe-gel. Ukutshintsha i-vickosity ye-HPMC kuvumela ulawulo oluchanekileyo lwenqanaba kunye nexesha lokukhululwa kweziyobisi.

Ukulungiswa okuzinzileyo
Amabakala okwazisa i-HPMC ahlala esetyenziswa kuphuhliso lweefomu ezizinzileyo zokukhutshwa. Le fomu iyilelwe ukwandisa ukukhululwa kweziyobisi, ukunciphisa rhoqo ukutyhoboza kunye nokuphucula ukuthotyelwa komonde.

5.Ukutya okuthengisiweyo

Ukulungisa imiceli mngeni
Ukukhetha ibanga le-HPMC efanelekileyo ye-HPMC liphenjelelwa ngokuqwalaselwa kwezemveliso. Amabakala e-Viscosity anokwenza imiceli mngeni ngexesha lokuqhutywa, njengokunyusa amaxesha okuxuba kunye nokudalwa kwezinto ezinokubakho. Iifomula zenzelwe ukuba zibethe ibhalansi phakathi kokufezekisa iprofayili yokukhutshwa kweziyobisi kwaye kuqinisekiswe ukuba kunokwenzeka inkqubo yokwenziwa kwemveliso.

Ukuhambelana nabanye abanomdla

I-HPMC ihlala isetyenziswa ngokudibeneyo nabanye abanomdla ukufezekisa iinjongo zokwenza oko. Ukungathobeki kwamabakala ahlukeneyo okufana nolunye uhlobo luqwalaselo oluphambili lokuqinisekisa uzinzo kunye nokusebenza kwefom yedosi yokugqibela.

Ukuqwalaselwa kolawulo ukuthotyelwa kwemigaqo
Ifomuli yeziyobisi kufuneka ifezekise imigangatho yolawulo, kwaye ukusetyenziswa kwe-HPMC ayifani. I-HPMC Viscosity yamabakala kufuneka ikhethwe ngokuhambelana neemfuno zolawulo kunye nezikhokelo ukuqinisekisa ukhuseleko, ukusebenza kunye nomgangatho wemveliso yamayeza.

I-HPMC Polymers idlala indima ebalulekileyo kuphuhliso lweenkqubo ze-hydrophilic ze-hydrophilic ze-hygrophilic zendlela yokukhutshwa kwamachiza alawulayo kwifomu yamayeza. Ukufumaneka kwamabakala ahlukeneyo okufakwa kwi-viscofity kunika iifomu ukuba ziguquguqukele kwiProfayili yokuThumela iziyobisi ngokusekwe kwiipropathi ezithile zeziyobisi kunye neethagethi zonyango. Ukukhetha ngononophelo lwebakala elifanelekileyo lokubonisa kubalulekile ekufezekiseni ukusebenza okufunwayo ngelixa kuchaziwe kwimveliso kunye nokulawulwa kokulawula. Njengoko uphando nophando lweziyobisi kunye nophuhliso luyaqhubeka, i-HPMC iya kuqhubeka idlala indima ephambili kuyilo lweenkqubo zokuhambisa neziyobisi.