Ukuphelisa i-hydroxypropyl methylcelcellulose (HPMC) kufuna ukuqonda iipropathi zayo kunye nokukhetha isolvent efanelekileyo. I-HPMC yi-selsulose ikhutshiwe isetyenziswa ngokubanzi kwiindawo zamayeza, ukutya, kunye nezicelo ezahlukeneyo zeshishini. Inyibilikiswa emanzini kodwa inepropathi ye-geni eyahlukileyo.
Iimpawu ze-Hydroxypropyl Methylcelcelgalose (HPMC):
Isakhiwo sekhemikhali:
I-HPMC yi-semi ye-semi-synthetic pollemer ethathwe kwi-seluplose. Inamacandelo amabini aphambili:
I-Selsulose BackBone: Inika ingqibelelo yesakhiwo.
I-HYDROXYPOPLL kunye ne-Methyl
Umoya wobuchule:
I-HPMC ibonisa ukugcwaliswa ngokugqwesileyo emanzini, ukwenza izisombululo ezicacileyo nezicacileyo. Nangona kunjalo, ireyithi yokuchithwa inokuhluka ngokuxhomekeka kwizinto ezinje ngamaqondo obushushu, inqanaba le-HPMC, kunye nobukho bezinye izinto.
I-Gel yenza iipropathi:
Ukongeza ekubeni yi-polymer enyibilikayo, i-HPMC inokwakha iiglasi phambi kwee-ions ezithile okanye ngegqwirha elibangelwa bubushushu. Le ndawo ibalulekile kwizicelo zamayeza kunye nokutya.
Izinto ezichaphazela ukupheliswa kwe-HPMC:
Iqondo lokushisa:
Ngokubanzi, ubushushu obuphezulu bunyusa umgangatho wokuchithwa kwe-HPMC. Nangona kunjalo, ubushushu obugqithisileyo bunokubangela ukungcwatywa, ukuchaphazela ukusebenza kwesisombululo.
Ph:
I-HPMC iyazinza ngaphezulu kwe-PH. Nangona kunjalo, iimeko ze-acidic okanye i-alkaline zinokuchaphazela ukupheliswa kwayo. Kwiimeko ezininzi, ukungathathi hlangothi okanye kancinci i-Alkaline PH kukhethwa ukutshiswa ngokupheleleyo.
Ibanga lePolymer:
Amabakala ahlukeneyo e-HPMC anemilinganiselo yemolekyuli eyahlukileyo kunye namanqanaba okwenza izinto, echaphazela isothulo lwabo. Ibanga le-Molecular Ibanga le-Molecular Ibamba liyanyibilikisa ngokukhawuleza.
Ubungakanani bentsundu:
Ukunciphisa ubungakanani be-HPMC yonyusa indawo yomphezulu ekhoyo yokuchithwa, ngaloo ndlela ikhawuleze inkqubo.
UTSHINTSHO LWE-Ityiwa:
Iityuwa ezithile, ezinje nge-sodium chloride, inokuchaphazela ukupheliswa kwe-HPMC. Banokuphucula okanye bathintele inkqubo, kuxhomekeka kwiimeko ezithile.
Izinyibilikiswa zokuphelisa i-HPMC:
Amanzi:
I-HPMC inyibilika emanzini, yenze isisombululo esicacileyo, se-viscous. Ireyithi yokupheliswa ichaphazelekile kubushushu bamanzi kunye ne-HPMC.
Izinyibilikisi ze-organic:
Nangona i-HPMC ithathelwa ingqalelo inyibiliza yamanzi, amanye amabakala anokunyibilika ngokuyinxalenye kwiinyibiliki ezithile ezifana ne-ethanol okanye i-methanol. Nangona kunjalo, ukusetyenziswa kwezinyibilikisi eziphilayo kunokuchaphazela ukhuseleko lwendalo esingqongileyo kunye nokhuseleko lwenkqubo.
Indlela yokuphelisa i-HPMC:
1. Ukusasazwa kwamanzi abandayo:
Ngokuthe ngcembe yongeza i-HPMC kwi-CAGMC kwi-odong tirness ngelixa ushukumisa rhoqo.
Vumela umxube hydrate iiyure ezimbalwa okanye ubusuku bonke.
Ukuba ukutshitshiswa ngokupheleleyo kuyafuneka, kunyusa amaqondo obushushu.
2. Inyibilikisiwe emanzini ashushu:
Dibanisa i-HPMC emanzini eshushu ngelixa ivuselela rhoqo.
Lawula amaqondo obushushu ukuthintela ukwakhiwa kwejell.
Vumela isisombululo sipholile ukufumana ukungangqinelani okucacileyo, ukungqinelana.
I-3. Ukudityaniswa nezinye iipolimers:
Ukuxuba i-HPMC kunye nezinye iibhokisi ezinyibilikayo zamanzi zinokuphucula iipropathi zalo zokuzola.
Le ndlela ixhaphakile kumalungiselelo ngamayeza.
I-4. Ukusetyenziswa kwe-surfacants:
Ukongeza i-surfacapes kunokuphucula amanzi emanzi kunye nokuchithwa kwe-HPMC.
Kufuneka kuthathelwe ingqalelo ukuqinisekisa ukungqinelana nesicelo esicetywayo.
5. Iimeko ze-ps ezilawulwayo:
Ukulungelelanisa i-pH ngaphakathi koluhlu olufanelekileyo kunokwenza ukuba i-HPMC.
Izisombululo ze-Buffer zinokusetyenziselwa ukugcina inqanaba le-ECH elifunayo.
Ukuqwalaselwa kukhuseleko:
Izixhobo zokhuselo lobuqu (i-PPE):
Nxiba izixhobo ezifanelekileyo zokhuselo, kubandakanya neegloves kunye neegogo, xa uphatha i-HPMC kunye nezinyibilikisi.
I-ventilation:
Qinisekisa ukuba indawo yomsebenzi ingena ngaphakathi ukunciphisa ukuvezwa kwe-fumes ye-solvent.
Uvavanyo oluhambelana:
Uvavanyo lokuhambelana kunye nezinye izithako ukuthintela ukusebenzisana okubi.
Impembelelo kwindalo esingqongileyo:
Qwalasela ifuthe lokusingqongileyo lendlela yakho ekhethiweyo kunye neyesiza.
Ukuphelisa i-hydroxypropyl methylcelcelsulose kubandakanya ukuqondeka iipropathi zayo, ukukhetha i-SOLLPER efanelekileyo, kwaye usebenzisa indlela efanelekileyo. Izinto ezifana nobushushu, i-PH kunye ne-Polymer Ibakala elidlala indima ebalulekileyo ekufezekiseni ukutyeshelwa ngokugqibeleleyo. Ukuqwalaselwa ngononophelo kwenkqubo yokhuseleko kunye nemicimbi yokusingqongileyo kubalulekile kuyo yonke inkqubo. Ngokulandela ezi ziKhokelo, umntu unokuchitha inyibilikisi i-HPMC ngezicelo ezahlukeneyo kwizicelo zamayeza, ukutya kunye nemveliso.
IXESHA LOKUQALA: FEB-19 ukuya ku-1525