Kuthatha ixesha elingakanani i-HPMC ukuze inyibilike?

I-HPMC (HydroxyPOpyl Methylcelceltulose) yipolymer esetyenziswayo esetyenziswayo kwi-picker yetafile yamachiza, iliso lamehlo kunye nezinye iimveliso. Ixesha lokuphelisa lixhomekeke kwizinto ezininzi, kubandakanya ubunzima bemolekyuli, ubushushu besisombululo, isantya esishukumisayo kunye nokugxininisa.

I-1. Ubunzima bemolekyuli kunye nenqanaba lokufaka endaweni
Ubunzima bemolekyuli kunye nesidanga sokufakwa endaweni (okt, i-Macyaxy kunye ne-Hydroxypropy) ye-HPMC iya kuchaphazela isothungela. Ngokubanzi, okukhulu ubunzima bemolekyuli, kuthathe ixesha elide ukunyibilikisa. Low viscosity HPMC (low molecular weight) usually takes 20-40 minutes to dissolve at room temperature, while high viscosity HPMC (high molecular weight) may take several hours to completely dissolve.

2. Iqondo lobushushu lesisombululo
Iqondo lobushushu lesisombululo linempembelelo ebonakalayo kwireyithi yokuchithwa kwe-HPMC. Amaqondo obushushu aphezulu ahlala ekhawuleza inkqubo yokupheliswa, kodwa amaqondo obushushu aphezulu kakhulu kunokubangela ukonakaliswa kwe-HPMC. Iqondo lokushishina ngokubanzi liphakathi kwe-20 ° C kunye ne-60 ° C, kwaye ukhetho olukhethekileyo luxhomekeke kwiimpawu ze-HPMC kunye nenjongo yokusetyenziswa.

I-3. Isantya esibethayo
Ukuvuselela kunokukhuthaza ukuchithwa kwe-HPMC. Ukuvuselela okufanelekileyo kunokuthintela ukwahlukana kunye nokuchasa i-HPMC kwaye kuyenze ichithwe kakuhle kwisisombululo. Ukukhethwa kwesantya esifudumeleyo kufuneka kulungiswe ngokwezixhobo ezithile kunye neempawu ze-HPMC. Ngokubanzi, iziphumo ezanelisayo zinokufezekiswa ngokukhuthaza imizuzu engama-20 ukuya kwengama-40.

I-4. I-Sout Ukugxilwa kwesisombululo
Uxinzelelo lwe-HPMC ikwayinto ephambili ekuqinisekiseni ixesha layo lokuchitheka. Ukugxininiswa okuphezulu, ixesha elide ixesha lokuchithwa lihlala lisiqhelo. Ngoxinzelelo oluphantsi (<2% W / W) Solutions, ixesha lokuchitheka linokuba lifutshane, ngelixa izisombululo zoxinzelelo zifuna ixesha elingakumbi lokunyibilikisa.

I-5. Ukukhethwa kwesinyibilikayo
Ukongeza emanzini, i-HPMC inokuchithwa kwezinye izinto ezifana ne-ethanol kunye ne-etholone glycol. I-polaty kunye nomoya wokunyibilikisa izinyibilikisi ezahlukeneyo ziya kuchaphazela inqanaba lokuphelisa i-HPMC kunye neempawu zesisombululo sokugqibela.

I-6. Iindlela zokuqala
Ezinye iindlela zokwenza ukuthandaza, ezinje nge-HPMC okanye isebenzisa amanzi ashushu, inokunceda ukukhawulezisa inkqubo yokupheliswa kwemali. Ukongeza, ukusetyenziswa kwe-AIDS yokuNikwa kweMithombo yoGawulayo njenge-surfacapes kunokuphucula ukuSebenza ngempumelelo.

Ixesha lokuchithwa kwe-HPMC lichaphazeleka ngezinto ezininzi. Ke ngoko, kwizicelo ezenziwayo, iimeko zokuchithwa kufuneka zilungiswe ngokweemfuno zosetyenziso ezithile kunye neempawu ze-HPMC. Ngokwesiqhelo, ixesha elifunekayo le-HPMC lokunyibilika phantsi kweemeko ezifanelekileyo ukusuka kwimizuzu engama-30 ukuya kwiiyure ezininzi. Ngeemveliso ezithile ze-HPMC kunye nemeko yesicelo, kuyacetyiswa ukubhekisa kwimiyalelo yemveliso okanye ukwenza uvavanyo ukumisela iimeko zexabiso eliphezulu kunye nexesha.