I-HPMC ibonelela njani i-viscofity engaguqukiyo?

I-HydroxyPOpyl Methylcelcelsele (i-HPMC) i-Ionic ye-Ionic, i-sell-inyibilikisi ye-ether i-Ioser esetyenziswayo isetyenziswa kumashishini ahlukeneyo njengamayeza, ukutya, i-cosmetics, kunye nolwakhiwo. Enye yeempawu zayo ezibalulekileyo kukukwazi kwayo ukubonelela ngohlobo olungaguqukiyo kwizisombululo kunye nefomu. Iindlela ezisemva kwe-HPMC ye-HPMC yokugcina izithembiso ezizinzileyo nezingaguqukiyo zininzi kwaye zinokuqondwa ngokuhlolisisa ubume bayo bemolekyuli, ukusebenzisana namanzi, kunye nokuziphatha phantsi kweemeko ezahlukeneyo.

Ubume bemolekyuli kunye nokuluka
I-HPMC isuselwa kwi-sellyulose, ipolymer yendalo equka iiyunithi ze-glucose ezidityaniswe yi-β-1,4-Glycosidic Bonds. Inkqubo yokuguqulwa ibandakanya ukuqaliswa kwe-Manexy kunye ne-hydroxypropy ye-hydropyl kwi-selsulose ngasemva, of in hydroxyropyl methylcelcelcelcelcelcelcelcelcelcelcelcelcelcelcelcelcelcelcelcelcelcelcelcelcelcelcelcelcelcelcelcelcelcelcelcelcelcelcelcelcelgalose. Olu hlengahlengiso luphucula ukubethwa kwe-HPMC kumanzi kunye nezinyibilikisi eziphilayo.

Inqanaba lokufakwa endaweni (DS) kunye ne-molar I-DS ibhekisa kwinani eliphakathi lamaqela e-hydroxyl endaweni yeyunithi ye-anhydroglucose, ngelixa i-MS ibonisa inani le-moles ye-mole ye-anhydroglucose. Ezi parameter zinefuthe lokungasebenzi kwe-HPMC, iipropathi ze-irmal, kunye novimba.

Iindlela zokungaguquguquki kwe-viscofity
I-hydration kunye ne-gell yejeli:
Xa i-HPMC yongezwa emanzini, apho kungena khona iimolekyuli zamanzi, apho iimolekyuli zamanzi zingena kwaye zinxibelelana namakhonkco ePolymere, ebangele ukuba badumbe. Inkqubo ye-hydration ikhokelela ekumiselweni kwenethiwekhi yejeyi efaka isandla kwi-viscofity yesosisombululo. I-hydration ichukunyiswa bubushushu, i-PH, kunye nobukho beetyuwa, kodwa isakhiwo se-HPMC siyakuvumela ukuba senze uthungelwano oluzinzileyo lwe-gel kuluhlu lweemeko.

Ubunzima bemolekyuli kunye ne-Polymer Chain Pain:
Ubunzima be-MPMUC ye-HPMC ichaphazela kakhulu i-viscofity yayo. I-polymers ephezulu yemolekyuli inamakhonkco amade, efaka ngokulula, yandisa i-viscofity yesosi. I-HPMC iyafumaneka kumabakala ohlukeneyo kunye neemolekyuli ezahlukeneyo zemolekyuli, zivumela ulawulo oluchanekileyo malunga nemveliso yokuphela kwemveliso. Ukuntywila kunye nokusebenzisana kwale mixokozi yePolymer Yenza inethiwekhi ebonelela nge-viscofity.

I-Termal:
I-HPMC ibonisa iipropathi zokungalawulekiswa ze-thermal eyahlukileyo, apho iyenza ijeli ekufudumeleni kwaye ibuyele kwisisombululo ekuphoxekeni. Olu hlaselo luphindaphindiweyo lubangelwa ziintsilelo kunye namaqela e-hydroxypropy, ephucula unxibelelwano lwe-hydrophobic kumaqondo obushushu aphakamileyo, ekhokelela kwi-gel yolwakhiwo. Ukupholisa, ezi ntsebenzo ziyancipha, kwaye ijeli iyanyibilika. Le ndawo iluncedo ikakhulu kwizicelo ezifuna utshintsho oluxhomekeke kubushushu ngelixa ugcina ukungangqinelani ngokubanzi.

Ukuziphatha kakuhle:
IZisombululo ze-HPMC zibonisa indlela yokuziphatha engasasebenziyo, isherating-ting, intsingiselo yokuthanda kwabo kuncipha ngokukhula kwenqanaba le-Shear. Le mpahla iqinisekisa ukuba phantsi kweemeko ezahlukeneyo zokulungisa, njengokuxuba okanye ukutyibilika, ukugcinwa kwezisombululo ze-HPMC uhlengahlengiswa ngokufanelekileyo kodwa kuyabuya kwimeko yeShear isuswe. Le ndlela yokuziphatha ye-Thixigropic inceda ukugcina i-viscofity engaguqukiyo ngexesha lokusetyenziswa.

Uzinzo lwePH:
Ngokungafaniyo nezinye ii-polymers ezininzi, i-HPMC ingakhathali kwiinguqu ze-pH kuluhlu lwe-3 ukuya kwi-11. Olu hlaziyo lubangelwa kukungabikho kwendalo engekhoyo, ethintelayo ekusebenzeni ngeeasids okanye kwiziseko. Ngenxa yoko, i-HPMC igcina i-viscofity engaguqukiyo kwi-PH ye-PH, esenza ilungele ukusetyenziswa kwezicelo ezahlukeneyo apho zinokutshintsha.

Izicelo ezizuza kwi-viscofity engaguqukiyo
Amayeza
Kwimigaqo yamayeza, i-HPMC isetyenziswa njenge-thi chickerer, i-binder, kunye ne-Arhente yokukhupha. I-viscosity yayo engaguqukiyo ibaluleke kakhulu ekuqinisekiseni ukuhanjiswa kwamachiza okulinganayo, ukumiswa kwezinto ngokuzinzileyo, kunye neeprofayili ezinokukhutshwa ngamachiza. Umzekelo, kwi-Chect Poings, i-HPMC iqinisekisa ukugungqa, nkqu nesicelo, kunye nezisombululo ze-Ophthalmic, ibonelela ngobungqingqwa obufanelekileyo bokunxibelelana ixesha elide ngamehlo.

Ishishini lokutya
Kwishishini lokutya, i-HPMC isebenza njenge-emulsifier, i-stabilizer, kunye ne-tickener. Ukukwazi kwayo ukubonelela ngobomi obungaguqukiyo kubalulekile ekugcineni ukuthungwa kunye nokuzinza kweemveliso ezifana neesosi, ukunxiba, kunye nezinto zobisi. Ipropathi ye-HPMC ye-HPMC iluncedo kakhulu kwiimveliso ezifuna utshintsho lwe-viscofity ngexesha lokupheka.

Ukwakhiwa
Kwizixhobo zokwakha, i-HPMC isetyenziswa kwisamente kunye nokwenziwa kwesamente ukuphucula ukusebenza, ukugcinwa kwamanzi, kunye nokunamathela. UVenkile olungaguqukiyo luqinisekisa ukuba ezi zixhobo zinokusetyenziswa ngokutyibilikayo kwaye zigcine ingqibelelo yazo ngexesha lokunyanga.

Cosmetics
I-HPMC iqeshwe kwiziko le-cosmetic lokuqina kunye nokuzinzisa iipropathi. Kwimveliso efana ne-ons, iikhrim, kunye ne-shamps, i-viscosity engaguqukiyo iqinisekisa ukwenziwa kwesiqhelo kunye nozinzo, ukuphucula amava omsebenzisi.

Izinto ezichaphazela i-viscofity kunye nolawulo lomgangatho
Izinto ezininzi zinokuba nefuthe kuhlobo lwezisombululo ze-HPMC, kubandakanya uxinzelelo, ubushushu, kunye nobukho bama electroneytes okanye ezinye izongezwa. Ukufezekisa i-viscofity engaguqukiyo, kubalulekile ukulawula ezi parameter ngexesha lokuqulunqwa kunye nokulungisa. Amanyathelo olawulo esemgangathweni abandakanya:

Ulukhetho lwezinto ezibonakalayo:
Ukuqinisekisa ukusetyenziswa kweselsose-gelity yeselula kunye nokugcina amanqanaba aguqukayo okufaka endaweni kunye nokufakelwa kwe-molar kubaluleke kakhulu ekuveliseni i-HPMC ngepropathi ethembekileyo.

Iinkqubo zeMveliso:
Iinkqubo ezilawulwayo, kubandakanya ulawulo oluchanekileyo lweemeko zokuphendula ngexesha lenkqubo yokwenziwa, zibalulekile ekuveliseni i-HPMC ngobunzima bemolekyuli kunye nepateni yokufaka endaweni yemolekyuli.

UVAVANYO LOLWAZI:
Ukuvavanywa kwenkqubo yohlalutyo kwee-HPMC iibatch zokubonisa, ukuhanjiswa kwesimo semolekyuli, kunye neepateni zokufaka endaweni zinceda ekuqinisekiseni ukungangqinelani kwemveliso. Iindlela ezifana nokubonisa i-vismestry, i-promation ye-chromatography yejeyi, kunye ne-nucleear yokwakhiwa kwe-nuctrascopy isetyenziswa rhoqo.

Ukugcina nokusingatha:
Ukugcina okufanelekileyo kunye nokuphatha i-HPMC ukuthintela ukuthathwa komswakama kunye nokuphefumla kubalulekile. I-HPMC kufuneka igcinwe kwizikhongozeli zomoya kunye neemeko ezipholileyo, ezomileyo zokugcina iipropathi zayo.

Isakhono se-HPMC sokubonelela nge-viscofity engaguqukiyo ukusuka kwisakhiwo sayo esahlukileyo semolekyuli, iipropathi ze-hydration, kunye nendlela yokuziphatha ye-thermal. Uzinzo lwayo ngaphaya kwamanqanaba e-PH eyahlukeneyo, iipropathi ezicekisekayo, kunye nentsebenzo ethembekileyo phantsi kweemeko ezahlukeneyo zenza ukuba ibe yi-polymer engathandekiyo kumashishini amaninzi. Ngokulawulwa ngononophelo kwiinkqubo zokuvelisa kunye namanyathelo okuqinisekiswa komgangatho, abavelisi be-HPMC baqinisekisa ukuba le prolymer ye-polymele iqhubeka iqhubeka nokudibana neemfuno ezinqabileyo zezicelo zawo ezahlukeneyo.