I-HPMC ichaphazela njani imveliso yemveliso?

I-HydroxyPOpyl Methylcelcelsulose (HPMC) yi-Polymer ye-solmmer esetyenziswayo esetyenziswayo kumzi mveliso, amayeza kunye nokutya. Omnye wemisebenzi ephambili ye-HPMC kwiimveliso ezahlukeneyo kukutshintsha kwe-viscofity, efezekiswa ngokwamandla kwayo kunye nokunxibelelana nezinyibilikisi (ngesiqhelo amanzi).

1. Ubume bemolekyuli ye-HPMC kunye nefuthe layo kwi-viscofity
I-HPMC iqulathe i-sellose yeselfowuni kunye ne-Management kunye ne-hydroxyproplonts. I-sellesese yayo iselselose ithwele inani elikhulu lamaqela e-hydroxyl, enokwenza iibhondi ze-hydrogen ngeemolekyuli zamanzi, ngaloo ndlela kuphuculwe i-viscosity yesisombululo. I-hydroxylpropy ye-hydropyl kunye ne-FOFSXY SPOSTUSS kwi-HPMC Mulecule ikwachaphazela ububele kunye nokungabinamandla ngamanzi. Emanzini, i-HPMC molecular inokuthi ityhileke kwaye ifumane inani elikhulu lamanzi, ngaloo ndlela kunyusa ukubonakala kwesisombululo.

Iindidi ezahlukeneyo ze-HPMC ziya kubonisa iimpawu ezahlukeneyo ze-viscofisity ngenxa yamanqanaba abo e-AFCREXY kunye ne-hydroxypropyl. Ngokubanzi, i-HPMC enenqanaba eliphezulu le-hydroxypropy inesiseko esomeleleyo se-viscosity-esandayo, ngelixa i-HPMC ene-mandosxy yendlela yokuchitha kunye nemvakalelo yobushushu. Ke ngoko, isakhiwo se-HPMC sinefuthe ngqo kwifuthe lokwanda kwayo.

2. Iimpawu zokutshabalalisa kunye ne-viscosity ye-HPMC
I-HPMC inomoya ofanelekileyo wokuzola kwamanzi, owenza ukuba ikhulise kakhulu kwizisombululo ze-accous. Emanzini, iimolekyuli ze-HPMC ifumana amanzi kwaye zenze ubume benethiwekhi eyandisiweyo, okukhokelela ekuncipheni kwesisombululo kunye nokunyuka kwe-viscofity. Le nkqubo yokutshintsha yinkqubo yenyathelo lenyathelo, kunye neqondo lobushushu kunye ne-pH ibe nempembelelo ebonakalayo kuyo. Ngokubanzi, i-HPMC iyanyibilikisa ngokukhawuleza amaqondo obushushu asezantsi, kodwa ukubonwa kwalo kunyuka ngokukhulisa ubushushu obukhulayo. Ke ngoko, ukuphelisa iqondo lokushisa i-chiotions ngaphakathi kuluhlu oluthile, kokukhona uVenkile enkulu yesisombululo.

Ukunyibilisela i-HPMC ikwanxulumene nexabiso le-pH liphakathi. Ekungathathi hlangothi kuluhlu lwe-alkaline ebuthathaka, i-HPMC inyibilikisa ngcono kwaye yonyusa i-viscofity; Ngelixa iphantsi kwemeko eqinileyo ye-acidic okanye i-alkaline, ukuluka kunye nokubonisa i-HPMC ayithintelwanga. Ke ngoko, kwiimveliso ezahlukeneyo, uhlengahlengiso lohlengahlengiso lwe-HPMC kufuneka luthathele ingqalelo ixabiso le-pH.

I-3. Iziphumo ze-HPMC kwi-viscofity
Uxinzelelo lwe-HPMC yenye yezona zinto ziphambili ezichaphazela uVeksity. Njengoko uxinzelelo lwe-HPMC, inethiwekhi ye-molecular ye-molecular eye yavela kwisisombululo iba nguDenser kwaye uVekyusi unyuka kakhulu. Ukugxininisa okuphantsi, ukusebenzisana phakathi kweemolekyuli ze-HPMC ze-HPMC zibuthathaka, kwaye i-vickosity yesisombululo ayitshintshi kakhulu. Nangona kunjalo, xa uxinzelelo lwe-HPMC lufikelela kwinqanaba elithile, ukunxibelelanisa umnqamlezo kunye nokuntywila phakathi kwamakhonkco eemolekyuli kuya kubangela ukuba i-viscofity iya kubangela ukuvela.

Iimvavanyo zibonisa ukuba xa uxinzelelo lwe-HPMC lungaphakathi kuluhlu oluthile, ukuvela kwalo kunyuka ngokwecala ngokuthe ngqo kuxinzelelo. Nangona kunjalo, xa uxinzelelo luphezulu kakhulu, ipropathi ye-suhemolocal yesisombululo iya kutshintsha, ibonisa i-pseudoplastity okanye i-Thixiopy, kunye ne-thscotdropy, kunye ne-thscotropy, kunye ne-fiixitions, kunye nokuvalwa kuncipha ukunyuka kwenqanaba le-Shear. Ke ngoko, kwizicelo ezenziwayo, isixa se-HPMC songezwe kufuneka silawulwe ngokufanelekileyo ngokweemfuno ezithile ukufezekisa i-viscofity efanelekileyo.

4. Isiphumo sobunzima bemolekyuli kwi-viscofity
Ubunzima bemolekyuli ye-HPMC ikwayinto ebalulekileyo ekuqinisekiseni i-viscofity yayo. Ngokubanzi, ukhubazeke kakhulu kwi-HPMC, ukuphakama kwe-viscomosity yesisombululo sayo. Kungenxa yokuba i-HPMC enemo elininzi yemolekyuli inokwenza imixokelelwane yemolekyuli ende kunye neenethiwekhi ezintsonkothileyo, ngaloo ndlela zithintela ulwelo lwesisombululo kunye nokunyusa i-vickosity. Ke ngoko, i-HPMC enemilinganiselo eyahlukileyo yeemolekyuli inokusetyenziselwa ukuhlengahlengisa iimfuno ze-viscofity yeemveliso ezahlukeneyo.

Kwezinye izicelo, ukukhetha i-HPMC ye-molecular ephezulu kunokuphucula kakhulu ukungangqinelani kwemveliso, njengento efana ne-thichoner ekwakheni izinto zokwakha; Ngelixa kwezinye iinkqubo, ezinje ngentsimi yamachiza, i-HPMOC ye-MOLECURC ephantsi inokufuneka ikhethwe ukuze ihlengahlengise inqanaba lokukhupha ichiza okanye ukuphucula incasa.

5. Iziphumo zobushushu kwi-viscosity yesisombululo se-HPMC
Uhlobo lwe-HPMC lutshintsha kakhulu kubushushu. Ngokubanzi, isisombululo se-HPMC sincipha kumaqondo obushushu aphezulu. Kungenxa yokuba ubushushu obuphezulu butshabalalisa iimbophelelo ze-hydrogen phakathi kwe-HPMC MOLEKIS kwaye zinciphisa inqanaba lokufakwa kwemixokelelwane yemolekyuli, ngaloo ndlela kunciphisa i-viscosity yesisombululo. Nangona kunjalo, kwezinye iimeko ezikhethekileyo, i-viscosity ye-HPMC inokunyuka ngaphakathi kuluhlu oluthile lobushushu, olunxulumene ngokusondeleyo kwimozulu yemolekyuli kunye nendawo yesisombululo.

Ngamaqondo obushushu asezantsi, i-viscosity yesisombululo se-HPMC iphezulu kwaye intshukumo yamakhonkco eemolekyuli ithintelwe. Le propati yenza ukuba izenze kakuhle kwizicelo apho i-viscosity yemveliso kumaqondo obushushu asezantsi kufuneka inyuswe.

6. Isiphumo senqanaba le-Shear kwi-viscosity ye-HPMC
Izisombululo ze-HPMC zihlala zibonisa iimpawu ze-Shear, oko kukuthi, i-viscofity ihla ngokuqalisa inqanaba loShear. Ngamaxabiso asezantsi asezantsi, ubume benethiwekhi ye-HPMC Muin igqitywe, nto leyo ethintela ulwelo lwesisombululo, ngaloo ndlela ibonisa i-viscofity ephezulu. Nangona kunjalo, kumazinga amachiza aphezulu, ukuntywila kunye nokudityaniswa komnqamlezo kuyatshatyalaliswa, kwaye i-viscosity ihla. Le mpahla isetyenziswa ngokubanzi kumashishini anjengezinto zokwakha, iipende kunye neengubo, kwaye unokuphucula ukungasebenzi kweemveliso ngexesha lokwakha.

I-7. Iziphumo zezongezo zangaphandle
Kwizicelo ezininzi, i-HPMC ihlala isetyenziswa kunye nezinye izongezelelo. Iindidi ezahlukeneyo zezongezo, ezinjengeetyus, i-surfcapes kunye nezinye iipolimers, ziya kuchaphazela i-viscosity ye-HPMC. Umzekelo, ezinye izandisi zetyuwa zinokunciphisa ukugcinwa kwezisombululo ze-HPMC kuba i-ion yetyuwa iphazamisana nonxibelelwano phakathi kwe-HPMC imixokelelwane kwaye itshabalalise i-hydrogen hard yot. Abanye abantu abaninzi banokusebenza ngokusebenzisa i-hpmcristic ukuya kwi-HPMC yokwandisa i-viscofity iyonke yesisombululo.

Njengesiphumo esisesikweni esisetyenziswa kakhulu, i-HPMC's kwimveliso yemveliso iphunyezwa ikakhulu kwimiphumo edibeneyo yemozulu yemolekyuli, uxinzelelo lwemolekyuli, i-solbabin, i-Solbability, inqanaba le-Shear kunye nezongezelelo. Ngokuhlengahlengiswa ngokuvakalayo ezi parameter ze-HPMC, ukulawulwa ngokuchanekileyo kwemveliso yemveliso inokufezekiswa ukufezekisa iimfuno zemimandla eyahlukeneyo yesicelo.