Izinto ezichaphazela ubomi beshelf ye-HPMC

I-Hydroxypropyl Methylcelceltulose i (HPMC) yindawo yemichiza emininzi esetyenziswayo esetyenziswa kwiindawo zamayeza, ukutya, izixhobo zokutya kunye nezinto zokwakha. Ubomi beshelheli yabo ibhekisele kubude bexesha elinokugcina iipropathi zayo zomzimba, zekhemikhali nez zomsebenzi phantsi kweemeko ezithile. Izinto ezichaphazela ubomi beshelufu ye-HPMC ibandakanya iimeko zokusingqongileyo, iimeko zokugcina, uzinzo lwamachiza, njl.

1. IiMeko zokusiNgqongileyo
1.1 Ubushushu
Iqondo lobushushu yenye yezona zinto zibalulekileyo ezichaphazela ubomi beshelup ye-HPMC. Iqondo lokushisa eliphezulu liya kukhawulezisa ukuphefumla kwe-HPMC, kukhokelela kutshintsho kwiipropathi zalo zomzimba kunye nekhemikhali. Umzekelo, i-HPMC inokujika ityheli kwaye inciphise i-viscofity yayo kubushushu obuphezulu, ichaphazela ukusebenza kwayo. Ke ngoko, ubushushu obungumaxesha afanelekileyo apho i-HPMC igcinwe kufuneka igcinwe kumaqondo obushushu asezantsi, ngokubanzi ngaphantsi kwe-25 ° C, ukongeza ubomi beshelup.

1.2 hula
Iziphumo zokufuma kwi-HPMC zibaluleke kakhulu. I-HPMC yimpahla ye-phullremer ye-polymer efumana ngokulula umswakama. Ukuba umswakama kwindawo yokugcina iphezulu kakhulu, i-HPMC iya kuthatha umswakama emoyeni, oko kukwenza ukuba i-viscofity yayo iguquke, ukuncipha kwayo kuncipha, kunye nokuzingisa kuye. Ke ngoko, i-HPMC kufuneka igcinwe yomile xa igcinwe, kwaye kuyacetyiswa ukuba umswakami olawulwa ngezantsi kwe-30%.

2. Iimeko zokugcina
2.1 Ukupakisha
Izinto zokupakisha kunye nokutywinwa zinefuthe ngqo kubomi beshelufu ye-HPMC. Izinto zokupakisha ezikumgangatho ophezulu zinokuhlukanisa umoya kunye nokufuma kwaye zithintele i-HPMC ukusuka ekuthini zimanzi kwaye ziwohloka. Izinto ezisetyenzisiweyo zokupakisha ezisetyenzisiweyo zibandakanya iingxowa ze-aluminium ze-aluminium, iingxowa zePolythylene, njl., Eneepropathi ezifanelekileyo. Kwangelo xesha, ukupakishwa okutywinwe kakuhle kunokunciphisa umfowunelwa we-HPMC kunye nendawo yangaphandle kwaye kwandisa ubomi beshelup.

2.2 Ukukhanya
Ukukhanya, ngakumbi i-Irradiolet i-Istraviot, inokubangela ukonakaliswa kwe-HPMC kwaye kuchaphazele iipropathi zayo zomzimba kunye nekhemikhali. Xa ityhilwe ukukhanya ixesha elide, i-HPMC inokuthi iqhubeke notshintsho lombala, i-molecular ye-molecular, njlnjl.

3. Uzinzo lwekhemikhali
3.1 Ixabiso le-pH
Uzinzo lwe-HPMC luchaphazeleka kakhulu kwixabiso le-pH. Ngaphantsi kweemeko ze-acidic okanye i-alkaline, i-HPMC iya kuthatha inxaxheba kwi-hydrolysis okanye i-Deviction Reactions, ekhokelela kwiingxaki ezinje ngokuhla kwe-viscosity kunye notshintsho kwi-sobability. Ukuqinisekisa ukuzinza kwe-HPMC, kuyacetyiswa ukuba ixabiso le-pH lesisombululo saso lilawulwa ngaphakathi koluhlu olungathathi hlangothi (PH 6-8).

3.2 Ukungcola
Ubukho bokungcola kuchaphazela uzinzo lwekhemikhali kwi-HPMC. Umzekelo, ukungcola ezinje nge-ion yentsimbi kusenokuthatha isigqibo sokuphelisa i-HPMC, kuvala ubomi beshelup. Ke ngoko, umxholo wezinto ezinqabileyo kufuneka ulawulwe ngokungqongqo ngexesha lenkqubo yokuvelisa kunye nezinto ezinqabileyo eziphezulu kufuneka zisetyenziselwe ukuqinisekisa ubunyulu be-HPMC.

4. Ifom yemveliso
Ifom yemveliso ye-HPMC ikwachaphazela ubomi beshelup. I-HPMC ihlala ikho kwimo yomgubo okanye kwigramles. Impembelelo yeefom ezahlukeneyo kubomi baso ishelufa imi ngolu hlobo lulandelayo:

4.1 IFomu yomgubo
Ifom ye-HPMC ye-HPMC inendawo enkulu yomhlaba kwaye icocekile i-hygroscopic kwaye ingcolisekile, ngoko ke ubomi bayo bungamfutshane. Ukwandisa ubomi beshelf ye-HPMC ye-HPMC, ukupakisha okutshuliweyo kufuneka kwenziwe ukuqinisekiswa ukunxibelelana nomoya kunye nokufuma.

4.2 I-paricle morphology
Amasuntswana e-HPMC anendawo encinci yomhlaba, aphantsi kwe-hygroscopic encinci, kwaye abe nobomi obude baseShelf. Nangona kunjalo, i-HPMC ye-HPMC inokuvelisa uthuli ngexesha lokugcina kunye nokuhamba, okukhokelela kubomi obufutshane. Ke ngoko, i-HPMC ye-GRMMC ikwafuna ukupakisha okuhle kunye neemeko zokugcina.

5. Sebenzisa izongezelelo
Ukwenzela ukuphucula uzinzo kwaye kwandise ubomi beshelufu ye-HPMC, ezinye abazinziyo okanye izinto ezizizo zinokongezwa ngexesha lenkqubo yemveliso. Umzekelo, ukongeza i-antioxididants ethintela ukonakaliswa kwe-HPMC, kunye nokongeza umswakama-iarhente yokubonisa ubungqina bunokunciphisa i-hygroscoficicicicicicicicy ye-HPMC. Nangona kunjalo, ukukhetha kunye nomongo wezinto ezongezelelwayo kufuneka ziqinisekiswe ukuba ziqinisekiswe ukuba ziqinisekiswe ukuba azichaphazeli iipropathi zomsebenzi kunye nokhuseleko lwe-HPMC.

Ubomi beshelup ye-HPMC buchatshazelwa zizinto ezininzi, kubandakanya iimeko zokusingqongileyo (iqondo lobushushu, iimeko zokugcina (ixabiso lemichiza (ifom ye-PH, ifom yemveliso) kunye nokusetyenziswa kwezicelo zongezintsomi. Ukuze wongeze ubomi beshelf ye-HPMC, ezi zinto kufuneka zithathelwe ingqalelo ngamanyathelo afanelekileyo kwaye ezifanelekileyo kufuneka zithathwe kulawulo. Umzekelo, gcina ubushushu obuphantsi kunye nendawo yogcino eyomileyo, sebenzisa indawo ekufutshane yokutopha ityhubhu, isisombululo se-ph, ulawulo lwe-HPMC lunokuqinisekiswa ngempumelelo kwaye ukusebenza kwawo kwiindawo ezahlukeneyo kunokuqinisekiswa.