Izinto ezichaphazela i-HPMC Viscosity

I-HydroxyPOpyl Methylcelcellulose (HPMC) sisisele esisetyenziswa ngokubanzi kwicandelo lezinto zokwakha, amayeza, ukutya kunye ne-cosmetics. Uhlobo lwe-HPMC yenye yeempawu zayo eziphambili zomsebenzi kuba ichaphazela ngokuthe ngqo ulwelo, iipropathi ezihlaziyayo, iipropati zegesi kunye nezinye iimpawu zezinto ezibonakalayo. Ke ngoko, qonda izinto ezichaphazela i-HPMC ibalulekile kwisicelo sayo kunye noyilo lwemveliso kwimimandla eyahlukeneyo.

1. Isiphumo sobunzima bemolekyuli
Ubunzima be-MPMC ye-HPMC inefuthe elibonakalayo kwi-vickosity. Ukukhululeka ubunzima bemolekyuli, ukuphakama kwe-viscosity yesisombululo. Kungenxa yokuba i-HPMC ene-molecular yemolekyuli yenza isakhiwo esinzima semolekyuli kwisisombululo, esonyusa ukuxabana kwangaphakathi kwesisombululo kwaye kukhokelela kukwanda kwe-vickosity. Kwangelo xesha, ubunzima obukhulu bemolekyuli buza kubangela utshintsho olunamandla lwendalo kwisisombululo ngexesha lokuhamba, kubaluleke kakhulu ekulawuleni intsebenzo, amachaphaza kunye nezinye iinkqubo. Zombini izifundo zovavanyo kunye nethiyori zibonisile ukuba ubunzima be-HPMC bubonisa ubudlelwane bamandla, oko kukuthi, i-viscosity ayikhulisi lula.

2. Impembelelo yenqanaba lokufaka endaweni
Inqanaba lokufakwa endaweni ye-hydroxypropyl (-C3chohch2-) kunye ne-methyl (-Cyl (-C3) kwi-HPMC yinto ephambili echaphazela i-smoubisity kunye nokubonisa. The degree of substitution refers to the proportion of hydroxyl groups (-OH) on the HPMC molecular chain substituted by hydroxypropyl and methyl groups. Xa inqanaba lokufakwa endaweni yamaqela e-hydroxypropy enyuka, ukusebenzisana phakathi kweemolekyuli ze-HPMC ze-HPMC ziya kubonakala buthathaka kwisisombululo esinamandla, ngaloo ndlela sandisa ukumiswa kwesisombululo; Ngelixa ukunyuka kwamaqela e-methyl kuya kudla ngokuphucula ubuhlambululo sesisombululo, okukhokelela ku-Soluba ukubanako, ngaloo ndlela ichaphazela i-viscosity. Ngokubanzi, i-HPMC enenqanaba eliphezulu lokufakwa endaweni inomhlaba ophakamileyo kunye nofanekiselo, kwaye inokuhlangabezana neemfuno ze-viscofity amasimi awahlukeneyo.

I-3. Isiphumo sesisombululo sesombululo
Uhlobo lwesisombululo se-HPMC inxulumene ngokusondeleyo noxinzelelo lwayo. Njengoko uxinzelelo lwesobuso luyanda, ukusebenzisana phakathi kweemolekyuli kunyuka kakhulu, kubangela ukubonwa kwesisombululo ukunyuka kakhulu. Kwiindawo ezinobuchule, iimolekyuli ze-HPMC zikho ngendlela yemixokelelwane yedwa, kwaye i-viscofity itshintsha kakuhle; Xa uxinzelelo lufikelela kwixabiso elithile elibalulekileyo, iimolekyuli ze-HPMC ziya kubambisa kwaye zinxibelelane, zenza ubume benethiwekhi, zibangela ukuba i-viscofity yeza kunyuka ngokukhawuleza. Ukongeza, ukwanda kwesisombululo kuya kubangela i-HPMC ukuze ibonakalise i-shear thicketion, oko kukuthi, i-vickosity iya kunyuka phantsi kwesenzo samandla aseShear.

I-4. Impembelelo yohlobo lwe-solvent
Uhlobo lwe-solvent ikwanefuthe elibalulekileyo kwi-solity kunye nohlobo lwe-HPMC. I-HPMC inokuchithwa emanzini kunye nezinye izinto eziphilayo (ezinjengeethanol, ethanol, i-acetone), kodwa izinyibilikisi ezahlukeneyo zinomelele kunye nokusasazeka okwahlukileyo. Emanzini, i-HPMC ihlala ikho kwifom ephezulu yobume be-viscofity, ngelixa kwizinyibilikisi eziphilayo zibonisa uVeksisity ongezantsi. I-polared ye-solvent inefuthe elikhulu kwi-viscosity ye-HPMC. Izinyibilikisi ezinamachaphaza aphezulu (njengamanzi) ziya kuphucula i-hydration yeemolekyuli ze-HPMC, ngaloo ndlela kunyusa ukubonakala kwesisombululo. Izicoci ezingezizo ezingezizo ezingenako ukunyibilikisa ngokupheleleyo i-HPMC, ebangela isisombululo sokubonisa i-viscofity esezantsi okanye ukungachithi ngokupheleleyo. Ukongeza, ukhetho kunye nomyinge womxube woSolvent uya kuchaphazela kakhulu ukusebenza kwe-viscofity ye-HPMC.

5. Iziphumo zobushushu
Iqondo lokushisa yenye yezinto eziphambili zokusingqongileyo ezichaphazela i-HPMC. Ngokubanzi, i-viscosity ye-HPMC iyancipha njengoko iqondo lobushushu liyanda. Kungenxa yokuba amaqondo obushushu aphezulu aya kutshabalalisa iibhondi ze-hydrogen kunye nolunye unxibelelwano phakathi kweemolekyuli ze-HPMC, ezenza amakhonkco eemolekyuli atyibilika ngokulula, ngaloo ndlela kunciphisa i-viscosity yesisombululo. Kumaqondo obushushu athile aphezulu, i-HPMC inokude iqhubeke ne-geling ukwenza umsebenzi ozinzileyo weNethiwekhi. Le ndawo yepropathi ye-Thermal isetyenziswa ngokubanzi kwizinto zokwakha kunye nemizi-mveliso yokutya njengoko inika i-viscofity efanelekileyo kunye nenkxaso yolwakhiwo. Ukongeza, amaqondo obushushu aneziphumo ezahlukeneyo kwi-viscosity ye-HPMCS enee-molestur ezahlukeneyo kunye nezigameko zokufaka endaweni. Ngokubanzi, i-HPMCs enemilinganiselo emikhulu yemolekyuli kunye namanqanaba aphezulu okufaka endaweni yokuthathela ingqalelo kuguquko lobushushu.

I-6. Iziphumo zexabiso le-pH
Nangona i-HPMC yi-polymer engathathi cala kwaye ingenakukhathazeka kakhulu kuguquko lwe-pH, uVenkile wayo unokuchaphazeleka phantsi kweemeko ze-pH ze-AID okanye kwi-Alkaline. Kungenxa yokuba imeko eqinileyo ye-acid okanye i-alkali iya kutshabalalisa ubume be-molecular ye-HPMC kwaye inciphise uzinzo, ngenxa yokwehla kwi-viscofity. Kwezinye izicelo, ezinjengamalungiselelo amachiza kunye nokongezwa kokutya, ulawulo lwe-PH kubaluleke kakhulu ukuqinisekisa ukuba i-HPMC Viscofity ihlala izinzile ngaphakathi kuluhlu olufanelekileyo.

7. Isiphumo sokwaphuka kwe-Ionic
Amandla e-Ionic kwisisombululo ikwachaphazela indlela yokuziphatha ye-HPMC. Imeko yamandla e-Ionic ephezulu iya kukhusela iindleko kwi-HPMC yamakhonkco, ukunciphisa ukuphiliswa kwe-electrostatic phakathi kweemolekyuli, kokwenza kube lula kwiimolekyuli ziyokufikelela, ngaloo ndlela kunciphisa i-viscofity. Ngokubanzi, xa ulungiselela izisombululo ze-HPMC AMANQAKU, I-ion yoxinaniso kufuneka ilawulwe ukuqinisekisa ukubonwa okuzinzileyo, okubaluleke kakhulu kwiziko lemifanekiso kunye ne-cosmetical.

Uhlobo lwe-HPMC luchaphazeleke zizinto ezininzi, kubandakanya ubunzima bemolekyuli, isidanga sokufakwa endaweni, ukugxininiswa kwesisombululo, uhlobo lwesimo, uhlobo lwe-solven, ixabiso le-pH kunye ne-Ionic. Ubunzima bemolekyuli kunye nesidanga sokufakelwa ikakhulu ichonge iimpawu ze-HPMPIC ze-HPMC, ngelixa iimeko zangaphandle ezinjengoxinzelelo lwesisombululo, uhlobo lwe-Solvent kunye nobushushu bachaphazela intsebenzo ye-viscofity ngexesha lokusebenza. Kwizicelo ezisebenzayo, iindidi ezifanelekileyo ze-HPMC kunye neemeko zolawulo kufuneka zikhethwe ngokweemfuno ezithile zokufezekisa intsebenzo efanelekileyo. Ukunxibelelana kwezi zinto kumisela ukusebenza kunye nemimandla esebenzayo ye-HPMC, ibonelela ngenkxaso ye-themoretical yesicelo sayo sokwakha, amayeza, ukutya kunye namanye amashishini.