Ukunyibilisela kwe-hydroxypropyl methylcelcelculose (hpmc, hpmc, hpmcroxypropyl Methylcelcelse) ichatshazelwe izinto ezininzi, kubandakanywa neemeko zayo zekhemikhali kunye nendawo yangaphandle. Ezi zinto zibaluleke kakhulu ekusetyenzisweni kwe-HPMC kunye nokusebenza kwayo kwinqanaba lamachiza, ukutya, ukwakhiwa kunye namanye amashishini.
I-1. Iipropathi zomzimba kunye neekhemikhali
1.1 Ubunzima beMolekyuli
Ubunzima bemolekyuli ye-HPMC luyinto ephambili echaphazela isothulo lwayo. Ngokubanzi, ukhubazeke ubunzima bemolekyuli, ukucotha kancinci inqanaba lokuphelisa. Kungenxa yokuba ubunzima obukhulu bemolekyuli bubangelwa ziimolekyuli zemolekyuli, ezonyusa ukuntywila kunye nokunxibelelana phakathi kweemolekyuli, ngaloo ndlela zinciphisa inkqubo yokupheliswa. Ngokuchasene noko, i-HPMC enengxaki encinci yemolekyuli iyanyibilika ngokukhawuleza, kodwa isisombululo se-vecosity sezulu sisezantsi, sisenza singakufanelekeli kwezinye iinkqubo.
1.2 isidanga sokufaka
Inqanaba lokufakwa endaweni ye-HPMC (okt inqanaba lokufakwa endaweni ye-APENCYICY kunye ne-hydroxypropoxy) nayo ichaphazela kakhulu ukuluka kwayo. I-HPMC enenqanaba eliphezulu le-Mazantsi Malunga ne-Hydroxypropoxy endaweni yokuba i-smollity ilunge ngakumbi emanzini kuba ezi zinto zinokuthatha izinto ezinokwandisa i-hydrophicicity yemolekyuli kwaye ikhuthaze i-hydration. Nangona kunjalo, ukwabana ngokugqithisileyo kunokukhokelela ekunciphiseni kwe-sloubing ye-HPMC kwiinyikima ezithile, ezinxulumene ne-polared ye-solvent kunye nokunxibelelana kwemolekyuli.
1.3 Ubungakanani be-suricle
Ubungakanani be-HPMC inefuthe ngqo kumgangatho wayo wokuchithwa. Inqaku elincinci le-paricle, eyona ndawo iphambili kwindawo ethile yeyunithi yeyunithi, kwaye le ndawo ivezwe kukunyuswa kwesinyibiliko, ngaloo ndlela kukukhawulezisa inkqubo yokuphelisa. Ke ngoko, i-HPMC kwifom yomgubo ye-powder ihlala inyibilikisa ngokukhawuleza kunefom ye-coarder granular.
I-2. Iimeko zeShoolvent
2.1 Uhlobo lweSolvent
Ukunyibilisela i-HPMC yahluka kakhulu kwizinyithi ezahlukeneyo. I-HPMC inomoya olungileyo emanzini, ngakumbi amanzi afudumeleyo. I-En-Accovents engekho mthethweni njenge-ethanol, i-propylene glycol, i-ethylene glycol, njl njl. Kumxube weSolvent, ukuluka kuxhomekeke kubungakanani bamacandelo kunye nokunxibelelana kwabo ne-HPMC.
2.2 Iqondo lobushushu
Iqondo lokushisa linempembelelo ebalulekileyo kwi-slobmc ye-HPMC. Ngokubanzi, i-HPMC iyanyibilika kancinci emanzini abandayo, kodwa njengoko iqondo lobushushu liyanda, ireyithi yokuchithwa inyuka kakhulu, kwaye yenza kakuhle kumanzi afudumeleyo angama-40-50 ° C. Nangona kunjalo, kumaqondo obushushu aphezulu (ihlala ingaphezulu kwama-70 ° C), i-HPMC inokutshintsha okanye yenze ijeli, enxulumene notshintsho kwiipropathi zalo kunye nolwakhiwo lwesisombululo.
2.3 Ixabiso le-pH
I-smollity ye-HPMC ithethwa kakuhle phantsi kweemeko ezahlukeneyo ze-ps, kodwa i-AID eqinileyo (njenge-Acid eyomeleleyo okanye ialkali) inokuchaphazela isothungela kunye nozinzo. I-HPMC ngokubanzi inobuntu obuhle kakhulu phantsi kwemeko ye-nehlatyhel okanye kufutshane ne-HOT.
I-3. Izinto zangaphandle zokusingqongileyo
3.1 Iimeko ezinomdla
Isantya kunye nendlela eshukumisayo inegalelo elibonakalayo kwiSantya sokuThibineka kwe-HPMC. Ukuvuselela okufanelekileyo kunokukhuthaza unxibelelwano phakathi kwe-HPMC kunye nesinyibilikisi ukuthintela ukuqhotyoshelwa, ngaloo ndlela ukukhawulezisa inkqubo yokuphelisa. Ukuvuselela ngokukhawuleza kunokubangela i-fubbs ukuba ifomu, ichaphazela ukufana kwesisombululo.
3.2 ukongeza
Ezinye izinto ezongezelelwayo kwisisombululo, ezinjengeetyus, i-elektrolytes, i-surficapes, njl. Njl. Umzekelo, iityuwa ezithile zinokukhuthaza ukuchithwa kwe-HPMC, ngelixa ukugxininiswa okuphezulu kwe-electronetity kunokubangela ukutshintsha okanye utshintsho lwe-viscosity ye-HPMC. Ukongezwa kwe-surfacapes kunokuphucula ukubethwa kwe-HPMC kwizinyithi ezithile ezingalunganga kwaye zisebenzele ukusebenza kwesisombululo.
4. Ukuqwalaselwa kwesicelo
4.1 Ishishini lamayeza
Kumzi-mveliso wamayeza, i-HPMC isetyenziswa ngokubanzi njengezixhobo ze-matrix kwilungiselelo lokukhululeka, kwaye ukulingana kwalo kuchaphazela ngqo inqanaba lokukhutshwa kunye nokungafumaneki kwexabiso lechiza. Ke ngoko, ukulawula ubunzima bemolekyuli, isidanga sokufaka kunye neemeko zokuhambisa i-HPMC kubalulekile ukulungiselela ngokufanelekileyo nangokuzinzileyo amalungiselelo.
4.2 Ishishini lokutya
Kumzi-mveliso wokutya, i-HPMC isetyenziswa njenge-thickener, i-stabilizer kunye ne-emulsifier. Ukuzola kwayo kugqiba ukusasazeka kwayo, ukuthungwa kunye nokuzinza ekutyeni. Ngokuhlengahlengiswa kweemeko zokuchitha, isiphumo se-HPMC ekutyeni sinokuphelelwa.
4.3 Imveliso yokwakha
Kwizinto zokwakha, i-HPMC isetyenziswa njengearhente yokugcina amanzi, i-tickener kunye ne-binder, kunye nokuzeliswa kwayo kuchaphazela intsebenzo yolwakhiwo kunye nomgangatho wokugqibela wokufa, amatyala kunye nezinye iimveliso. Ukulungelelanisa iimeko zokuchitha kunye neendlela zesicelo ze-HPMC inokuphucula isiphumo sosetyenziso kunye nokuqina kwento leyo.
Ukunyibilisela i-HPMC kuyachaphazeleka ziipropathi zomzimba kunye neekhemikhali ezinjengomonde wemolekyuli, isidanga sokufakwa endaweni, kunye neemeko zesandla, kunye nexabiso le-SOLVent efana nexabiso lendalo. Kwizicelo ezisebenzayo, ukubethwa kunye nokusebenza okusebenzayo kwe-HPMC kunokwenziwa ngokufanelekileyo ngokukhetha ngokusesikweni kukukhetha kunye nokulawula ezi zinto ngokweemfuno ezithile kunye neemeko ezithile. Ukuqonda okunzulu kwezi zinto kuya kunceda ukuphucula isiphumo sesicelo se-HPMC kwimizi-mveliso eyahlukeneyo kwaye sinike inkxaso ubugcisa betekhnoloji kwimimandla enxulumene noko.
IXESHA LOKUQALA: NgoFebruwari-17-2025