INTSHAYELELO NGOKUFANELEKILEYO KWEEMFUNO ZAMAKWENYANISO KWEEMFUNO ZOKWENZIWA KOMSEBENZI EZIQHELEKILEYO Malunga nokuphucula ukusebenza kwekhonkrithi, ukusetyenziswa kwemiyalelo yindlela ebalulekileyo. I-HydroxyPOpyl Methylcelcelsulose (HPMC), njengemichiza eqhelekileyo ye-selsulose, isetyenziswe ngokubanzi ekwakhiweni, iingubo, i-gypsum, udaka kunye namanye amasimi. Njengeseli-inyibiliki enyibilikayo yamanzi, inesithukuthezi esihle, ukugcinwa kwamanzi, ukuqulunqwa kwefilimu kunye nokuphuculwa kokusebenza kwesakhiwo. Nangona kunjalo, ifuthe le-HPMC kwikhonkrithi yekhonkrithi isesihloko esifanelekileyo.
Iipropati ezisisiseko ze-HPMC HPMC yi-polymer yemvelo yendalo emanzini, ihlala ifunyanwa ngokutshintsha imichiza, kunye ne-hydrophicicity ethile kunye nokunamathela. Ekhonkrithi, i-HPMC ikakhulu idlala indima yokutshutshiswa, ukugcinwa kwamanzi, ukuphucula ulwahlulo, kunye nokwandisa ixesha lokusebenza. Ingaphucula ulwakhiwo nolwakhiwo lwesamente inamathisele, ngaloo nto iphucule ukusebenza kwekhonkrithi.
Iziphumo ze-HPMC kwikhonkrithi yekhonkrithi
Ukugcinwa kwamanzi kwi-HPMC kwi-CETHE HPMMC inemisebenzi eyomeleleyo yokugcina amanzi, enokuthi icothe ngempumelelo inkqubo yokuphuma kwamanzi kwaye igcine imeko ye-hydration ye-centence. Ingakumbi kubushushu obuphezulu okanye indawo eyomileyo, umphumo wokugcinwa kwamanzi we-HPMC kubaluleke kakhulu. Impendulo ye-hydration yesazisi sencasa ifuna inkxaso eyaneleyo yamanzi. Ukuba amanzi aqhekeza ngokukhawuleza, amasuntswana enza amasuntswana awayi kuba ngama-hydising ngokupheleleyo, enze iipores, eza kuchaphazela ukuxinana kwekhonkrithi. I-HPMC ilibazisela ukuvela kwamanzi ukuqinisekisa ukuba amasuntswana ethutyana anokuphumeza ngokupheleleyo, ngaloo ndlela ukuphucula ukuxinana kwekhonkrithi.
Isiphumo se-HPMC kwi-HINTERE FLUIty HPMC, njenge-thi churner, inokuphucula ulwelo lwekhonkrithi. Isixa esifanelekileyo se-HPMC sinokwenza ikhonkrithi sine-slidity elungileyo kwaye sinciphise i-subreanon yekhonkrithi ngexesha lokugalelwa. Ikhonkrithi enobuqhetseba obungcono unokugcwalisa ubumba ngexesha lokugalelwa, ukunciphisa isizukulwana seebhubhu kunye nee-faids, kunye nokuphucula ukuxinana kwekhonkrithi. Nangona kunjalo, ukuba i-Dosage ye-HPMC ininzi kakhulu, inokubangela ukuba i-vipcosity yekhonkrithi yokuphakama kakhulu, ichaphazela ukungabi nzima, kwaye kunokubangela ukuba i-voids kwikhonkrithi ingakwazi ukuzaliswa ngokupheleleyo, ngaloo ndlela ichaphazela ububi.
I-HPMC's i-HPMC yamasuntswana amasuntswana afanelekileyo kwi-HPMC inokuphucula ukusasazeka kwamasuntswana amanzi emanzini kwaye enze ngokulinganayo amasuntswana asasazwa ngokulinganayo kwi-centence paste. Ukusasazwa ngokufanayo kwamasuntswana yesamente kuyanceda ukunciphisa ukwahluka kwe-Ageglouration yamasuntswana amakhulu ekhonkrithi, ngaloo ndlela kuncitshiswa ukuthambeka kunye nokuphucula ukulandelwa kwekhonkrithi. Ukuba umthamo we-HPMC mkhulu kakhulu, inokubangela umkhosi oxhonyiweyo phakathi kwamasuntswana okuqina, ophumela kwi-viscound yesamente kunye nokudityaniswa kwekhonkrithi.
Impembelelo ye-HPMC kwinkqubo yokuqina kwekhonkrithi ye-HPMC idlala indima yokuyibamba i-qumed yokuphendula yekhonkrithi, ngakumbi kwi-Shranti yokuHlala, eya kuthi iphucule inkqubo yekhonkrithi. Inkqubela phambili ecothayo yokuphendula ngokucotha i-shydration inceda ekwenzeni ijeli ye-cell yesamente, ukunciphisa ukwenziwa kweepores, kwaye kuphucule ukwenziwa kwekhonkrithi. Nangona kunjalo, ukuba idosi ye-HPMC iphakame kakhulu, inokubangela ukulibaziseka kakhulu kwinkqubo ye-hydrate, echaphazela indawo yokuphucula amandla kunye nokuzinza kwekhonkrithi.
Isiphumo se-HPMC kwikhonkrithi yekhonkrithi ye-HPMC inolwazi olunamandla, linokunciphisa i-micrographic kwaye lisebenzise ngokufanelekileyo i-microcracks kunye ne-pores kwikhonkrithi, ngaloo ndlela kuphucula ukungafezeki kwekhonkrithi. Ngokwenza umthamo we-HPMC, ukuxinana kwekhonkrithi kunokuphuculwa, ukungena kwemithombo yeendaba yangaphandle njengamanzi kunye neekhemikhali kunokuncitshiswa, kwaye ukuqina kwekhonkrithi kungaphuculwa.
Uluhlu olufanelekileyo lwe-HPMC ye-HPMC ngokoPhambili koPhando, ifuthe le-HPMC Dosage kwikhonkrithi yekhonkrithi, kwaye ayinakuba phantsi kakhulu okanye iphezulu kakhulu. Xa idosi iphantsi kakhulu, isiphumo esibi se-HPMC asonelanga kwaye ayinakuphucula ngokufanelekileyo ubulwele kunye nokugcinwa kwamanzi kwikhonkrithi; Xa idosi iphakame kakhulu, inokubangela i-viscofity eninzi, ichaphazele ukusebenza kokwakhiwa, kwaye ndibangele i-faid kunye nemingxunya. Ke ngoko, umthamo we-HPMC kufuneka ulawulwe ngaphakathi kuluhlu olulandelayo. Ngokwedatha yophando eyahlukileyo, umthamo we-HPMC ulawulwa ngokubanzi phakathi kwe-0.1% ne-0.3%. Kakhulu okanye idosi esezantsi kakhulu iya kuba nefuthe elibi kubuninzi kunye nezinye iipropathi zekhonkrithi.
Isiphumo se-HPMC Isixa esifanelekileyo se-HPMC sinokuphucula ukusebenza kwekhonkrithi, ukuphucula ukuxinana kwekhonkrithi, kunye nokuphucula amandla kunye nokuqina. Nangona kunjalo, i-dompas ephezulu kakhulu okanye iphantsi kakhulu iya kuba nefuthe elibi kwikhonkrithi yekhonkrithi. Ke ngoko, kwizicelo ezenziwayo, umthamo we-HPMC kufuneka ukhethe ngokufanelekileyo ngokweemfuno zokusetyenziswa kunye neemeko zekhonkrithi ukufezekisa ukusebenza kwekhonkrithi.
Ixesha lasemva: ngoFebruwari-15-2025