Iicapbules ezinzima / i-HPMC ye-Capsules / i-HPMC ye-Capsules / i-capsules yemifuno / i-api ephezulu ye-API kunye nezithako ezinobuthathaka / iFilimu yeFizikhali / itekhnoloji ye-OSD / itekhnoloji ye-OSD / yeTekhnoloji ye-OSD ....
Ukusebenza ngendleko ezisebenzayo, ukulungiselela ukuveliswa kwemveliso, kunye nokukhululeka kolawulo lomda wedosi, umthamo oqinileyo oqinileyo (i-OSD) ahlala ekhethiweyo lolawulo lwabaphuhlisi.
Ye-38 yeemowudi ezitsha zemolekyuli ezincinci (i-NMES) ezivunyiweyo nguLawulo lwe-US kunye noLawulo lweziyobisi ngo-2019, 26 yayingu-OSD1. Ngo-2018, ingeniso yentengiso yeemveliso ze-OSD ezinxibelelene ne-CMO kwimarike yaseMelika i-7,2 yeedola.
Iicwecwe zisalawula imakethi ye-OSD, kodwa iicapsules ezinzima ziba yinto enokubakho ngakumbi. Oku kungenxa yesiqhelo ngenxa yokuthembeka kweecapsules njengeyona ndlela yolawulo, ngakumbi abo bane-potelity antitory apis. Iicaphule zisondelelene nezigulana, imaski engathandekiyo ivumba kwaye zinambithe, kwaye kulula ukuginya, zingcono kakhulu kunezinye iifomu zedosi.
UJulien Lamps, umphathi wemveliso kwi-lonza capsules kunye nezithako zempilo, uxoxa ngezinto ezininzi zecapbules ngaphezulu kweetafile. Ubelana ngokuqonda kwakhe kwi-Hydroxypropyl Methylcelculose (HPMC) i-Capsules kunye nendlela abanokunceda ngayo abaphuhlisi bamachiza xa behlangana njani kwimfuno yamayeza athathwayo.
Iicapyules ezinzima: Ukuphucula ukuthotyelwa kwezigulana kunye nokwandisa intsebenzo
Izigulana zihlala zisokola ngamayeza ancancisayo okanye anuka kubi, kunzima ukuginya, okanye kunokuba nemiphumo emibi. Ngale nto engqondweni, ukuphuhlisa iifom ze-dosage ezinobuhlobo kunokuphucula ukuthotyelwa kwesigulana ngeerejimeni zonyango. Iicapsules ezinzima yindlela enomdla kwizigulana kuba, ukongeza kwi-Masking Cace kunye ne-odor, zinokuthathwa kancinci, zinciphise umthwalo wethebhulethi, kwaye zinciphise izihlandlo zokukhululwa, ngokusebenzisa ukukhululwa ngokukhawuleza, ukukhululwa okukhulu ukuze kufezekiswe.
Ulawulo olungcono lokukhulula indlela yokuziphatha kwechiza, umzekelo nge-micropelleting i-API, inokuthintela ukulahla inkunkuma kwaye kuncitshiswe iziphumo ebezingalindelekanga. Abaphuhlisi beziyobisi bafumanisa ukuba ukudibanisa itekhnoloji ye-Prountratication nge-Cepsules yonyusa ukuguquguquka kunye nokusebenza kwenkqubo yokukhutshwa kwe-API. Inokukuxhasa i-pellets enee-API ezahlukileyo kwi-capsule enye, okuthetha ukuba amachiza amaninzi anokulawulwa ngaxeshanye kwiidosi ezahlukeneyo, ukunciphisa i-frequency yedosi.
Ukuziphatha kwe-pharmaconkinic kunye ne-pharmacodynamic yezi fom, kubandakanya nenkqubo ye-Multiptones4, i-Spresion Spreronition API3, kunye nenkqubo yokudibanisa idosi eyi-5, kunye nenkqubo yokudibanisa idosi eyi -5, ikwabonisa ukuba kubhetele xa kuthelekiswa nokwenziwa kwenkqubo eqhelekileyo.
Kungenxa yolu phuculo lunokwenzeka lokuthobela isigulana kunye nokusebenza ngokukuko ukuba imfuno yentengiso ye-APIL ye-APIS engevameke kwi-capsules ezinzima iyaqhubeka ukukhula.
I-Polymer Phambilo:
Isidingo seziqwenga zemifuno ukuba zithathe indawo ye-gelatini ye-gelatini
Iicaphules zemveli zenziwe nge-gelatin, nangona kunjalo, iicaphuli ezinzima kakhulu zinokubakho kwimiceli mngeni xa iqulethe imixholo yovavanyo okanye umswakama. I-Gelatin yimveliso ethatyathwe sisilwanyana ethambekele ekuphelisweni kwenkqubo yokunxibelelanisa, kwaye inomxholo wamanzi aphezulu ukugcina bhetyebhetye, kodwa inokutshintshana namanzi nge-apis kunye nabanelisi.
Ukongeza kwimpembelelo ye-capsule ufaka kwintsebenzo yemveliso, izigulana ezingaphezulu ziyathandabuza ukwenza iimveliso zezilwanyana zezentlalo okanye zenkcubeko kwaye zifuna amayeza ezityalo okanye vegan. Ukuhlangabezana nale mfuno, iinkampani zamayeza zinokuqhubeka nokutyala imali kwiirejimeni ze-cappevative zokuphuhlisa ezinye iindlela ezisekwe kwizityalo ezikhuselekileyo neziphumelelayo. Inkqubela phambili kwiSayensi yeSoftware yenze ukuba i-capsules ye-tipsules yezityalo inokuthi ifumaneke, ihambisa abaguli i-on-spreen of Gelatin-Sun of Phulatin-Sele off, kunye nempumelelo.
Ukuchitheka okungcono kunye nokuhambelana:
Ukusetyenziswa kwe-HPMC
Okwangoku, enye yezona ndlela zilungileyo eGelatin yi-Hydroxypropyl MethylcelcelcelcelUlose (HPMC), i-polymer ethathwe kwimigca yomthi.
I-HPMC ingaphantsi kwe-helist ye-helit kune-getitin kwaye ifunxa amanzi amancinci kuneGelatin6. Umxholo wamanzi asezantsi we-HPMC unciphisa ukutshintshiselana kwamanzi phakathi kwecapsule kunye neziqulatho, ezinokuthi kwezinye iimeko zinokuphucula uzinzo lwekhemikhali, kwaye zihlangabezane nemiceli mngeni ye-apis ye-hygroscopic ze-APIs kunye ne-nexlores. I-HPMC Holfw Capsules ingakhathali kubushushu kwaye kube lula ukugcina nokuhambisa.
Ngokwanda kwe-APIs ephezulu, iimfuno zefomula ziya zisiba ngaphezulu nangakumbi. Ukuza kuthi ga ngoku, abaphuhlisi beziyobisi baphumelele iziphumo ezilungileyo kakhulu kwinkqubo yokuphononongwa kokusetyenziswa kweecaphus ze-HPMC ukuba zithathe indawo yemveli ye-gelatini. Ngapha koko, i-HPMC Capsules ikhethwa ngokutsha kwiimvavanyo zeklinikhi ngenxa yokuhambelana neziyobisi kwaye zinomdla7.
Ukuphuculwa okuqhubekayo kwitekhnoloji ye-HPMC ikwathetha ukuba abaphuhlisi beziyobisi bayakwazi ukusebenzisa ithuba leeparamitha zalo kunye nokuhambelana noluhlu olubanzi lwe-NMES, kubandakanya amabala anamandla amakhulu.
I-HPMC Capsules ngaphandle kwe-Gell Geling ineepropathi ezingenayo ngaphandle kwe-Ion kunye nokuxhomekeka kwe-PH, ukuze izigulana ziya kufumana ichiza kwisisu esingenanto okanye ngokutya. Njengoko kubonisiwe kumzobo 1. 8
Ngenxa yoko, ukuphuculwa kokutya okunokuthi kuchithiwe kunokuvumela abaguli ukuba bangabi nazimgangatho ofanelekileyo malunga nokushenxisa iidosi zabo, ngaloo ndlela benyusa ukuthotyelwa.
Ukongeza, ukuqhubeka kongeza izisombululo ze-HPMC Capsule Membrane ze-Memprane zinokwenza ukhuseleko lwamathu e-phecanali kunye nokuhanjiswa kweziyobisi kwiindlela ezithile zonyango, kunye nokuphucula izicelo ezinokubakho ze-HPMC.
Olunye umkhombandlela wesicelo we-HPMC CAPULES use kwizixhobo zokuphefumla kolawulo lwePulmonary. Imfuno yentengiso iyaqhubeka ukhula ngenxa yokufumana i-biareas ephuculweyo ngokuthintela isiphumo sokudlula kwi-hepatic kwaye sijolise kwisifo esithe ngqo esifana nesifo se-asthma kunye nesifo sokutsala isifuba (CORD) ngale ndlela yolawulo.
Abavelisi beziyobisi bahlala bejonge ukuphucula unyango oluneendleko, kunye nolungelelene lwezifo zokuphefumla, kunye nokuphonononga unyango lokuphefumla iziyobisi zezifo ze-nervieds. Imfuno iyanda.
Umxholo wamanzi asezantsi we-HPMC ubangela ukuba balungele i-hygroscopic okanye i-apis ebuthathaka yamanzi, nangona ipropathi ye-elektrostatic phakathi kokuqulunqwa kunye ne-capsules ephakathi kunye ne-capsules engekhoyo nayo kufuneka ithathelwe ingqalelo kuphuhliso oluthile.
Iingcinga zokugqibela
Ukuphuhliswa kweTekhnoloji ye-Mgrane kunye neTekhnoloji ye-OSD ibeke isiseko se-HPMC CAPULES ukuba sithathe indawo ye-gelalin ye-gelatini kwezinye iinkqubo, ukubonelela ngeendlela ezininzi zokwenza umsebenzi wemveliso. Ukongeza, ukwanda kugxininiswa kukhetho lwabathengi kunye nokunyuka kwemfuno yamachiza angabizi kangako khulise imfuno yeecopsules ezinamachaphaza anemolekyuli ebuthathaka yokufuma.
Nangona kunjalo, ukhetho lwezinto ze-membrane lusitshixo lokuqinisekisa impumelelo yemveliso, kwaye ukhetho olufanelekileyo phakathi kweGelatin ne-HPMC lungenziwa kuphela ngobungcali obufanelekileyo. Ukhetho oluchanekileyo lwezinto ze-membrane alunakukuphucula ukusebenza ngokulula kunye nokunciphisa imeko engathethekiyo, kodwa ikwanceda ukoyisa imiceli mngeni ethile.
Ixesha leposi: NgoFebwe-20 ukuya ku-525