Ngaba i-hydroxypropyl methylcelceluplose ne hypromellose efanayo?

I-HydroxyPOpyl Methylcelcelsele (i-HPMC) kunye ne-hpromellose yimigaqo esetyenziswayo ngokuchaseneyo, kodwa babhekisa kwinto enye. I-HPMC yindawo yokufakwa kwe-seluplose, kunye ne-hypromellose ligama lehlabathi liphela (i-Inn) leli candelo. La magama asetyenziswa ngokufuthi kumashishini amayeza kunye nokutya, phakathi kwezinye, ngenxa yezinto zabo eziguquguqukayo.

Hydroxypropyl methylcelcelculose (hpmc) / hpmc) / hypromellosemet yesakhiwo:

I-HydroxyPOpyl Methylcelcelose sisimo se-sellulose eguqulweyo. Utshintsho lubandakanya ukongezwa kwe-hydroxypropy kunye namaqela e-Managesy kwi-selsulose backbone. I-seluplose yi-Polysacchaacchaacchaaccharide yePolysaccharide edityaniswe ngeeyunithi zeglucose ezidityaniswe yi-β-1,4-Glycosidic Bonds. Ukuqaliswa kwe-hydroxypropyl (-och2ch (oh) i-CH3) kunye ne-APEXY (-och3) amaqela anika iipropathi zeselula, ephucula isolula, i-viscosity kunye nezinye iipropathi.

Inqanaba lokufakwa endaweni (DS) libhekisa kwinani eliphakathi lokuthenga izinto nge-Anhhydroglucose kwikhonkco leselselose. Kwimeko ye-HPMC, ukwahluka kwi-DS kunokukhokelela kumabakala ahlukeneyo kunye neepropathi ezahlukeneyo, zenza ukuba zizixhobo ezahlukeneyo kwizicelo ezahlukeneyo.

Iimpawu ze-Hydroxypropyl Methylcelceluplose:
Ukungasebenzi kunye nokuqulunqwa kwejell:
I-HPMC inyibilikisa emanzini ngaphezulu koluhlu lobushushu olubanzi, kwaye ukuluka kuxhomekeke kwizinto ezinje ngenqanaba lokufaka endaweni kunye nobunzima bemolekyuli. Ubukho be-hydroxypropy kunye namaqela e-AFGISY ukuba negalelo kumoya wayo emanzini abandayo, owenza ilungele ukusetyenziswa ngeendlela ezahlukeneyo.

I-Viskosity:
Enye yepropathi ephambili ye-HPMC kukukwazi kwayo ukutshintsha i-viscosity yesisombululo. Amabakala ahlukeneyo e-HPMC enee-viscofis ezahlukeneyo ziyafumaneka ngokuxhomekeka kwiimfuno ezithile zokuqulunqwa.

I-Fible yeFom:
I-HPMC icacisa iifilimu ezicacileyo neziguquguqukayo, zenza ukuba zibe lixabiseke kwizicelo eziqengqelekayo kumashishini okutya kunye nokutya. Iipropathi zokwenza ifilimu zibaluleke kakhulu ekuvelisweni kweefom zomthamo oqinileyo zomlomo kunye ne-confecionery.

Thetha:
I-HPMC ibonakalisa uzinzo ngaphezulu kwe-PH ebanzi, igalelo kukonyusa indlela eyahlukeneyo. Ixhathisa ukonakaliswa kwe-callmmatic kunye nokuhlaselwa kwentsholongwane, kuqinisekisa ukuzinza kweemveliso zamachiza.

Izicelo zamayeza:
Ithebhulethi yeTafile:
I-HPMC isetyenziswe ngokubanzi kumzi-mveliso wamayeza kwithebhulethi. I-Coim Coatings isebenza ngeenjongo ezahlukeneyo, kubandakanya imaski yokungcamla, ukukhusela iziyobisi kwizinto zokusingqongileyo, kunye nokukhutshwa kwemvume.

Ukulungiswa okuzinzileyo:
Ukukhutshwa okulawulwayo kunye nokuzinza kweziyobisi yinxalenye ephambili kuphuhliso lwamachiza. I-HPMC isetyenziselwa ukwenza iinkqubo ze-matrix ezivumela ukukhululwa ngokuthe chu iithafa zamayeza ezisebenzayo (APIS) ngexesha elide.

Amalungiselelo e-Ophthalmic:
Kwifomu ye-OphThalmic, i-HPMC isetyenziselwa ukwandisa i-viscofity ye-visp eyehla kwaye i-prondong yexesha lonxibelelwano kunye nomgangatho we-ocular. Oku kuphucula isiphumo sonyango lwechiza.

Izicelo eziphezulu nezigqithileyo:
I-HPMC ifakiwe kwifomu eqondakalayo efana ne-gels kunye neekhrim ukubonelela nge-viscofity kunye nokuphucula ukusasazeka kwemveliso. Ikwasetyenziswa kwiziqwengana zenguqu zokulawula ukukhululwa kwamachiza ngolusu.

Ulwelo lomlomo:
I-HydroxyPOpyl Methylcelcelgalose isetyenziswa ekuqulunweni kweefom zomlomo olwenziweyo ukomeleza i-viscosity, ukunqumamisa amasuntswana, kunye nokuphucula ukuthoba.

Izicelo zeshishini lokutya:
I-tickener:
I-HPMC isetyenziswa njengearhente yokuthambisa kwiimveliso ezahlukeneyo zokutya, kubandakanya iisosi, ukunxiba kunye needessert. Ukukwazi kwayo ukutshintsha i-viscofity kunceda imveliso yokugqibela ifezekise ubume obufunayo.

I-tickener:
Kwezinye izicelo zokutya, i-HPMC inokuthatha amanyathelo njengearhente yeGell, incedisa ukwenza ii-geses okanye ukuzinzisa ii-emulsions.

Iglasi kunye neengubo:
I-HPMC isetyenziswa ekwenziweni kokutya kunye nekhredithi ukuphucula ukubambelela, imbonakalo kunye nokugcinwa komswakama. Yenza ifilimu ebonakalayo ekhuthaza isibongozo esibonakalayo seemveliso zokutya.

Ukufakwa endaweni yefa
Njenge-hydrocolloid, i-HPMC inokusetyenziswa njengokufaka endaweni yefomu enamafutha asezantsi okanye amanqatha anefutha, ukubonelela ngolungelelwano kunye nomlomo ngokufana nemveliso enamafutha aphezulu.

Imiceli mngeni kunye nokuqwalaselwa:
Ngelixa i-hydroxypropyl methylcelcelsulose yinto eguquguqukayo enoluhlu olubanzi lwezicelo, kukho iingcinga ezithile kunye nemiceli mngeni kwisicelo sayo:

Imvakalelo yobushushu:
Ukunyibilika kwe-HPMC kuchatshazelwa bubushushu. Amanye amabakala anokukubonisa ukunciphisa ukunqunyulwa kwamaqondo obushushu aphezulu, efuna ukuqwalaselwa ngenyameko ukwenziwa kwayo.

I-hygroscopicity:
I-HPMC i-hygroscopic, okuthetha ukuba ifumana ngokulula umswakama kwindalo esingqongileyo. Le propati kufuneka ithathelwe ingqalelo kwifomu apho umxholo wokufuma ubalulekile.

Ukuhambelana kweziyobisi
Kwizicelo zamayeza, ukuhambelana phakathi kweziyobisi kunye ne-polymer kubalulekile ekuqinisekiseni uzinzo kunye nokusebenza kwemveliso yokugqibela.

Imeko yolawulo:
I-Hydroxypropyl Methylcelcelsele yamkelwe ngokubanzi kwaye yamkelwe ziiarhente zolawulo ezinjengee-US ngokutya kunye ne-Arhente yeziyobisi (i-EMA). Idweliswe kwi-pharmacopoeia njengento ebonakalayo yamalungiselelo amachiza amayeza.

I-Hydroxypropyl Methylcelceluplose Methylceltulose Methylceluplose Methylceluplose Methylceltulose Methylceltulose Methylcelgalose Methylceltulose Methylceltulose Methylceluplose Methylceluplose, ngokufuthi njenge-hypromellose, yi-polymer eqhelekileyo kunye noluhlu olubanzi lwezicelo kumashishini okutya kunye nokutya. Iipropathi zayo ezizodwa, kubandakanya ukubethwa, i-viscosity yemodyuli, amandla okwenza ifilimu kunye nozinzo, yenza isithako esixabisekileyo kwizinto ezahlukeneyo zokwenziwa.

Ukusuka kwi-Chebrings Ikhreyithi kunye neefom zokukhutshwa kwandiselweyo kwii-tikketicals ukuya kwishishini lokutya, i-HPMC idlala indima ebalulekileyo ekwandiseni intsebenzo kunye neepropathi zoluhlu olubanzi lweemveliso. Ukukwazi ukulungisa iipropathi zayo ngokuhlengahlengiswa kwenqanaba lokufaka endaweni kunye nemolekyuli ngakumbi kunegalelo ekuziqhelanise nezicelo ezahlukeneyo.