Ukusetyenziswa kwe-Hydroxypropyl Methylcelcelcelose kumzi-mveliso wamachiza

I-Hypromellose (i-HPMC) sisifo seselselose esisetyenziswe ngokubanzi kumzi-mveliso wamayeza ngenxa yepropathi yayo esebenzayo kunye ne-biomatise. Iindawo zayo eziphambili zesicelo ziquka ii-binders zecwecwe, iinkampani ezizahluliweyo, izixhobo zokuhamba, iiarhente zokukhupha, kunye nokulungiselela amachiza amane kunye neegels.

I-1. I-Binders

Imveliso yetafile, i-HPMC njenge-Binder inokuphucula amandla okubopha amasuntswana enzala, ukubangela ukuba benze iitafile ezizinzileyo ngexesha lokutshekisha. I-HPMC Binders inezi zinto zilandelayo:
Ukuphucula amandla oomatshini: Inethiwekhi ye-viscous eyenzelwa yi-HPMC kwithebhulethi inceda ukuphucula amandla omatshini wecwecwe kwaye kunciphise umngcipheko wokoqobo kunye nokunciphisa umngcipheko.
Ukuphucula ukufana: Ngenxa yokungabinamntunga kwawo emanzini, i-HPMC inokusasazwa ngokulinganayo kumphezulu wamasuntswana okuqinisekisayo umxholo oguqukayo kwithebhulethi nganye.
Uzinzo: I-HPMC ibonisa uzinzo oluhle phantsi kweemeko ezahlukeneyo zobushushu kunye neemeko zokufuma, kwaye zinokugcina ulwakhiwo lwethebhulethi ngelixa kungaphantsi kwempembelelo yokusingqongileyo.

I-2. I-Interinter

Umsebenzi wokuvalelwa kukwenza iitafile zibulala ngokukhawuleza emva kokunxibelelana nolwelo ukukhutshwa izithako zamachiza. I-HPMC inokukhuthaza ngokufanelekileyo ukwahlula-hlulwa kwetafile ngenxa yepropathi yakhe yokudumba:
Ukudumba kwe-hydmc: Xa i-HPMC iza kudibana namanzi, kuya kukhawulezisa amanzi kwaye kuyandul 'ukutshaya, kubangela ukuba kubekho ithebhulethi ukungcungcutheka, ngokukhululekileyo izithako zamachiza.
Ukulungisa ixesha lokungasebenzi kakuhle: Ngokuhlengahlengisa i-HPMC, ixesha lezinto ezichithekileyo lweetafile linokulawulwa ngokuchanekileyo ukuze lifezekiswe iimfuno zokukhupha amachiza ahlukeneyo.

I-3. Izixhobo zokuKhangela

I-HPMC idlala indima ebalulekileyo kwithebhulethi. Isakhono sayo sefilimu kunye nefuthe lokukhusela kwiziyobisi lenza ukuba ibe yinto efanelekileyo yokuhamba:
Ukudibana
Ukuphucula imbonakalo: Ukudibana kwe-HPMC kunokubonelela ngomphezulu womphezulu we-HEAT, ukuphucula imbonakalo kunye nokukhululeka kokuginya kweetafile.
Ukulungelelanisa ukukhululwa kweziyobisi: Ngeefom ze-HPMC ezahlukeneyo kunye nobugqwetha okuthile, ukukhutshwa okulawulwa okanye ukukhutshwa okuzinzileyo kunokufezekiswa.

I-4. Iiarhente zokukhupha ezizinzileyo

I-HPMC isetyenziswa ngokubanzi kumalungiselelo okukhululeka. Ngokusebenzisa i-gel verrier imbi, inokulibazisa ukukhutshwa ngamachiza kwaye ifezekise unyango lwexesha elide:
I-Gel Arriers: Kwimithombo yeendaba emanzini, i-HPMC inyibilikisa i-viscous gel, enokulawula inqanaba lokukhupha ichiza.
Ukukhutshwa kwezinzile: UVeksisity kunye nokugxininiswa kwe-HPMC kungalawulwa ngokuchanekileyo ukuze kufezekiswe ukukhululwa iziyobisi ezinokuzinza.
Ukuncitshiswa rhoqo kwamayeza: Iifom zokukhutshwa ezizinzileyo zinokunciphisa irejista yonyango ukuze zifumane izigulana kwaye ziphucule ukuthotyelwa kunye nokusebenza kakuhle konyango lweziyobisi.

5. Amalungiselelo olwenzi kunye neegels

I-HPMC idlala indima ebalulekileyo njenge-thi cokener kunye nokuzinzisa kumalungiselelo olwelo kunye ne-Gels:
Isiphumo sokuqaqamba: I-HPMC yenza isisombululo se-colloidal efanayo emanzini, enokwandisa i-viscofity yamalungisa amanzi kunye nokuphucula uzinzo.
Isiphumo sokuzinzisa: i-HPMC inokugcina i-viscofity elizinzileyo phantsi kweemeko ezahlukeneyo, ezinceda ukuzinzisa izithako zamachiza kwaye zithintele ukuqina kunye nokuxhuma.

6. Ezinye izicelo

I-HPMC ikwasetyenziselwa ukulungiselela amalungiselelo e-Ophthalmic, amalungiselelo empumlo kunye namalungiselelo okulungiselela ukusetyenziswa:
I-Ophthalmimic: I-HPMC isetyenziswa njengeoyile kwiinyembezi zenziwe iinyembezi kunye neliso lamehlo ukuze zinciphise iimpawu zeliso elomileyo.
Amalungiselelo e-nasal: Njenge-thickener kwiziqendu zempumlo, i-HPMC inokwakha ixesha lokugcina iziyobisi kwi-Nasal Cavity.
Amalungiselelo aphezulu: i-HPMC inokwenza ifilimu yokukhusela kumalungiselelo aphezulu ukunceda ekuncedeni iziyobisi kulusu ixesha elide.

Njengokungafuneki okusebenzayo, i-Hydroxypropyl Methylcelcelgalose isetyenziswa ngokubanzi kumzi-mveliso wamachiza. Imisebenzi yayo emininzi yokwenza imveliso yecwecwe, iqengqele, iZilungiso eziGqibeleleyo, amalungiselelo olwenzi kunye nee-geses ziphucula umgangatho kunye nozinzo lwamalungiselelo eziyobisi. I-HPMC iye yaba yinto engenakuphikiswa nebaluleke kakhulu kumzi-mveliso wamayeza ngenxa ye-bimoMPini eyobalaseleyo kunye neepropathi ezisebenzayo. Kwixa elizayo, ngokuphuhliswa okuqhubekayo kwetekhnoloji yamayeza, ithemba lesicelo le-HPMC kwiPhando kunye noPhuculo kunye noYilo luya kubanzi.