UKUSETYENZISWA KOKUSETYENZISELWA I-EERE KWI-HORT YOKUGQIBELA Itekhnoloji

UJosefu uBrama wayila inkqubo yokuphumelela ekuvelisweni kwemibhobho ekhokelayo ngasekupheleni kwenkulungwane ye-18. Kwakungekho kude kube phakathi kwenkulungwane ye-19 itekhnoloji eshushu eshushu yaqala ukusetyenziswa kwishishini leplastiki. Yaqala ukusetyenziswa okokuqala kwimveliso yokufaka impahla ye-polymer ngeewoyili zombane. Itekhnoloji yeTekhnoloji yanamhlanje isetyenziswa kakhulu kungekuphela nje ekuvelisweni kweemveliso ze-polymer, kodwa nakwimveliso nokuxubusha ngokwazo ngokwazo. Okwangoku, ngaphezulu kwesiqingatha seemveliso zeplastiki, kubandakanya iingxowa zeplastiki, amaphepha eplastiki kunye nemibhobho yeplastiki, ziveliswa ngokusebenzisa le nkqubo.

Emva kwexesha, le teknoloji ivele ngokuthe ngcembe kwintsimi yamayeza kwaye ngokuthe ngcembe yaba yitekhnoloji engenakuphikiswa. Ngoku abantu basebenzisa itekhnoloji yokulungisa i-curritus egudileyo, ukulungiselela iigranu, iitafile ezikhulelweyo, ezihamba phambili kunye nenkqubo yokuhambisa iziyobisi, kutheni abantu bethanda le teknoloji ngoku? Isizathu senziwe ikakhulu kuba xa kuthelekiswa nenkqubo yemveliso yesiko kwitekhnoloji yexesha elidlulileyo, iteknoloji eshushu ineengenelo:

Phucula inqanaba lokuchitheka kwezichiza ezinyibilikayo

Kukho izibonelelo zokulungiselela ukwenziwa kokukhutshwa okuzinzileyo

Ukulungiswa kweearhente zokukhutshwa kwe-gestrointentinal ngokulinganayo

Ukuphucula ubuchule bokuthandela

Inkqubo ye-Scalling ifezekisiwe kwinyathelo elinye

Vula indlela entsha yokulungiselela ii-microullets

Phakathi kwazo, I-Sete Ether idlala indima ebalulekileyo kule nkqubo, masenze ukujonga isicelo se-selsulose yethu kuyo!

Ukusetyenziswa kwe-Ethyl Selelose

I-Ethyl Selelose luhlobo lwe-hydrophobic ye-hydrophose. Kwintsimi yamayeza, ngoku isetyenziswa kwi-microncappapsution yezinto ezisebenzayo, isinyibilikisi kunye ne-piiling yetafile kunye nokuzithambisa kweetafile zokukhupha ezilawulwayo kunye neebhloko. I-Ethyl Selelose inokunyusa imilinganiselo eyahlukeneyo yemolekyuli. Iqondo lobushushu leglasi liyi-129-133 degrees Celsius, kwaye inqaku layo lokunyibilika liyinto eyi-180 degrees Celsius. I-Ethyy Seluplose ilukhetho olufanelekileyo lokuphumelela kuba ibonisa iipropathi ze-Thermoplastic ngaphezulu kweqondo lobushushu beglasi kwaye lingaphantsi kobushushu bayo.

Ukwenzela ukuthoba ubushushu benguqu yeglasi yee-polymers, eyona ndlela ixhaphakileyo kukongeza iiprimplizers, ngenxa yoko inokusetyenzwa kubushushu obuphantsi. Ezinye iziyobisi zinokwenza njengeziphatho ngokwazo, ngenxa yoko akukho mfuneko yokuphinda yongeza iiplasitiki ngexesha lenkqubo yokuqulunqwa kweziyobisi. Umzekelo, kwafunyaniswa ukuba iifilimu ezikhutshiweyo eziqukethwe i-Ibuprofen kunye ne-Sethyl Selelose yayineqondo lokushisa elisezantsi leglasi kunemiboniso bhanyabhanya equkethe kuphela i-sellyulose. Ezi filimu zinokwenziwa kwilabhoratri ene-screw-screw ejikelezayo. Abaphandi balingene kwi-powder kwaye emva koko bahlalutyo. Kwavela ukuba ukwandisa inani le-ibuprofen kungasehlisa amaqondo obushushu eglasi.

Olunye uvavanyo yayikukudibanisa ukuzonwabisa kwe-hydrophilic, i-hyprelllose, kunye ne-guntan gum ukuya e-Ethylcelsulose ne-Ibuprofen micromatics. Kwagqitywa kwelokuba i-micromatimarix iveliswe yindlela eshushu ye-meltrusic ye-wills evuthayo ineemveliso zokufumana iziyobisi kunemveliso efumanekayo kwezorhwebo. Abaphandi bavelise i-micromatix esebenzisa i-leboraring yelebhu yelebhu kunye ne-twin-screw desterter ene-3-mm cylindrical die. I-Spired-Sika amaphepha aphethwe ngesandla 2 mm ubude.

I-HYPROFLLLLSE

I-Hydroxypropyl Methylcelcelcelose yi-hydrophilic seluplose i-ether i-cloble i-colloidal yesisombululo esicacileyo okanye esincinci esincinci emanzini abandayo. Isisombululo esikhulu sinomsebenzi womphezulu, ukungafihli nto kunye nokusebenza ngokuzinzileyo. Ukunyibilikisa kuyahluka nge-viscosity. Ezantsi kokufakwa kwe-viscosity, kokukhona ukonakala. Iipropathi ze-hydroxypropy i methylceltulose eneenkcukacha ezahlukeneyo zahlukile, kwaye ukuchithwa kwayo emanzini akuchaphazeleki kwixabiso le-pH.

Kumzi-mveliso wamachiza, kudla ngokusetyenziswa kwi-matrix elawulwayo ye-matrix, ithebhulethi yokudibanisa, njl. Njl. Ngenxa yeqondo layo eliphezulu leglasi kunye nobushushu obuphantsi, ayisetyenziswanga ngokubanzi kwitekhnoloji yokutsala eshushu. Ukwenzela ukwandisa ubungakanani bayo bokusebenzisa, indlela enye kukudibanisa kuphela isixa esikhulu seplastiki kwiNkqubo yokuSebenza njengoko abaphengululi babini besitsho, kwaye basebenzise i-trustrix ye-therix ye-therix yakhe ubuncinci i-30%.

I-Ethylcellulose kunye ne-hydroxypropymethylcelcelcelcelcelose inokudityaniswa ngendlela eyahlukileyo ekuhanjisweni kwamachiza. Enye yeefom ze-dosage kukusebenzisa i-Ethlolceluplose njenge-tube yangaphandle, kwaye ilungiselele iBakala Hypromellose ye-Hypromellose. Isiseko se-seluplose.

Ityhubhu ye-ethylcellulose iveliswa esebenzisa i-pubsing eshushu kumatshini ojikelezayo kwilebhu yokufaka i-ring tube, isiseko senziwa ngesandla, ilandelwe nguShumindlonce. Izinto eziphambili zezinto eziphambili zenziwa ngesandla kwi-piholine. Injongo yesi sifundo yayikukuphelisa isiphumo sokwenza impompo ngamanye amaxesha senzeka kwi-hydroxlypropyl methylcelcelcelcelcelcelcelces. Abaphandi abafumani mahluko kwireyithi yokukhupha i-Hydroxypropyl Methylcelcelose ye-viscofity efanayo, nangona kunjalo, endaweni ye-hydroxypropyl methylceluplose ne methylceluplose ikhutshelwe kwixabiso lokukhupha ngokukhawuleza.

Umbono

Nangona inyibilikisi eshushu yitekhnoloji entsha kwishishini lamayeza, itsalele ingqalelo enkulu kwaye isetyenziselwa ukuphucula ukuveliswa kweefom ze-dosage ezahlukeneyo kunye neenkqubo. Itekhnoloji yokuphumelela eshushu i-meltrusion iye yaba yitekhnoloji ephambili yokulungiselela ukusasazeka okuqinileyo phesheya. Kuba imigaqo yayo yobugcisa iyafana ngeendlela ezininzi zokulungiselela, kwaye isetyenzisiwe kwamanye amashishini iminyaka emininzi kwaye iqokelelweyo ngamava amaninzi, inamava ophuhliso ngokubanzi. Ngokwenza nzulu kophando, kukholelwa ukuba isicelo sayo siya kwandiswa ngakumbi. Kwangelo xesha, itekhnoloji ye-sult-meltrusion eshushu ineendlela ezincinci zokunxibelelana namachiza kunye nenqanaba eliphezulu le-automation. Emva kotshintsho kumzi-mveliso wamachiza, kukholelwa ukuba utshintsho lwalo lwe-GMP luya kukhawuleza.